Development of a Simulation Technique for Gene/Cancer Therapy Using Nano/Micro Bubbles
| Project/Area Number |
22656047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Fluid engineering
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,410,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | 流体工学 / ナノ・マイクロバブル / 治療性分子 / 衝撃波 / 液体ジェット / 流対工学 / 音響性リポソーム / Ghost Fluid法 / 表面張力 / 力積 / シミュレーション / 拡散抵抗 / 動的表面張力 |
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| Research Abstract |
This study is aimed to develop a technique for gene therapy using bubble collapse. The motion of acoustic liposomes under pressure change is investigated experimentally and a bubble model for acoustic liposomes is developed. The collapse of a bubble near a tissue surface is simulated using the boundary element method or the ghost fluid method. A simulation technique is also developed for the transport of therapeutic molecules using bubble collapse. It is shown that the bubble motion is much affected by the variation of surface tension due to the reduction of phospholipid layers on the bubble surface. The tissue boundary velocity is correlated to the impulse at the tissue due to bubble collapse. The usage of vortex flows generated by the liquid jet accompanied with bubble collapse is effective in transporting the molecules.
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Report
(3 results)
Research Products
(40 results)
