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Fablication of porous 3-D structure from poly(L-lactide)-based nano-composites.

Research Project

Project/Area Number 22656148
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Composite materials/Physical properties
Research InstitutionToyota Technological Institute

Principal Investigator

OKAMOTO Masami  豊田工業大学, 工学部, 准教授 (60288553)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,580,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsナノコンポジット / ポリ乳酸 / 3次元連結ナノ多孔体 / 再生医療
Research Abstract

In order to prepare the porous three-dimensional(3-D) structure in biodegradable polyester materials we have conducted the enzymatic degradation of a poly(L-lactide)(PLLA)-based nano-composite foam having nanocellular structure, using proteinase-K as a degrading agent at 37℃. The surface and cross sectional morphologies of the foam recovered after enzymatic hydrolysis for different intervals were investigated by using scanning electron microscope. The nanocelluar took up large amount of water, which led to the swelling of the foam due to the large surface area inside the nanocelluar structure, and facilitated the enzymatic degradation of matrix PLLA as compared with the bulk(pre-foamed) sample. Consequently, we have successfully prepared a porous 3-D structure as a remaining scaffold in the core part of the nano-composite foam, reflecting the spherulite of the crystallized PLLA. To understand the effect of the foam structure on the enzymatic degradation and porous structure development, we have examined the enzymatic degradation of a poly(L-lactide)(PLLA)-based nano-composite foam having different cell density(microcellular and nanocellular), using proteinase-K as a degrading agent at 37℃. The surface and cross sectional morphologies of the foam recovered after enzymatic hydrolysis for different intervals were investigated by using scanning electron microscopic and mercury porosimetric analyses. The fabrication of porous three-dimensional structure for tissue engineering scaffolds and the degradation performance in nano-composite foams were demonstrated.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Fabrication of Polylactide based Biodegradable Thermoset Scaffolds for Tissue Engineering Applications2012

    • Author(s)
      Reika Sakai, Baiju John, Masami Okamoto, Jukka V. Seppala, Jayasheelan Vaithilingam, Husnah Hussein, Ruth Goodridge
    • Journal Title

      Macromolecular Materials and Engineering

      Volume: 298 Issue: 1 Pages: 45-52

    • DOI

      10.1002/mame.201100436

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Porous 3-D Structure from Poly(L-lactide)-based Nano-composite Foams2010

    • Author(s)
      Masami Okamoto
    • Journal Title

      Proceeding of IMRC2010

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Porous 3-D Structure from Poly(L-lactide)-based Nano-composite Foams2010

    • Author(s)
      岡本正巳
    • Journal Title

      Proceeding of IMRC2010

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Fabrication of Porous 3-D Structure from Poly(L-lactide)-based Nano-composite Foams2010

    • Author(s)
      Masami Okamoto
    • Organizer
      International Materials Research Congress 2010(IMRC2010)
    • Place of Presentation
      メキシコ,カンクン
    • Year and Date
      2010-08-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Fabrication of Porous 3-D Structure from Poly(L-lactide)-based Nano-composite Foams2010

    • Author(s)
      岡本正巳
    • Organizer
      International Materials Research Congress 2010 (IMRC2010)
    • Place of Presentation
      メキシコ、カンクン
    • Year and Date
      2010-08-17
    • Related Report
      2010 Annual Research Report
  • [Book] 新しいプラスチックの成形技術と材料2010

    • Author(s)
      岡本正巳
    • Publisher
      (株)大阪ケミカル・マーケティング・センター
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Remarks] 研究内容又は研究成果に関するwebページ

    • URL

      http://www.toyota-ti.ac.jp/Lab/Zairyo/5z50/okamoto.htm

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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