| Budget Amount *help |
¥3,470,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Research Abstract |
Centromeres and telomeres are the two specialized chromatin domains both serving for stable chromosome inheritance. Intriguingly, their location and functionality often change simultaneously in the course of chromosome evolution. We experimentally analyzed such an interrelationship, if any, between centromeres and telomeres. We found that de novo centromere formation stimulated by centromere dysfunction requires the telomere as a domain located at the end of chromosomes, which is mediated by telomeric heterochromatin and the other factors.
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