| Project/Area Number |
22657033
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAOSA Kazushige 金沢大学, 薬学系, 助教 (70401891)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,240,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | 細胞競合 / 発癌 / ショウジョウバエ / 発生 / 細胞貪食 / アポトーシス / 紬胞競合 / 細胞貧食 |
|---|
| Research Abstract |
We generated a Drosophila line that lacks receptors responsible for the phagocytic removal of apoptotic cells. These flies had prolonged larval stage, indicating the importance of apoptotic cell clearance in growth. To determine the characteristic of' loser cells', which remain in animals due to a defect in phagocytosis, a mosaic mutation for artificial cell competition was introduced into a phagocytosis-deficient fly line. However, we could not complete the examination of these flies within the allocated research period.
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