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Analysis of molecular mechanisms of the acquisition of tumor invasiveness and metastasis

Research Project

Project/Area Number 22657045
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionHokkaido University

Principal Investigator

HASHIMOTO Sigeru  北海道大学, 大学院・医学研究科, 准教授 (50311303)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,360,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords癌浸潤 / 癌幹細胞 / マクロファージ / 乳癌細胞 / 細胞間融合 / Arf6 / GEP100 / AMAP1
Research Abstract

In 1911, Otto Aichel postulated the concept of cell fusion as a mechanism of tumor malignancy. Recently, there are a lot of clinical and experimental discoveries of cell fusion as one of the driving forces of tumor progression. However, its molecular mechanisms remain to be elucidated. We have previously shown that GEP100-Arf6-AMAP1 signaling pathway contributes to the acquisition of invasiveness of some breast cancer cells. Here, we found that Arf6 and GEP100 were involved in the regulation of cell-cell fusion between highly invasive breast cancer cells, or bone marrow-derived cells.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) Book (2 results) Remarks (2 results)

  • [Journal Article] GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis2011

    • Author(s)
      Hashimoto A., Hashimoto S., Ando R., Noda K., Ogawa E., Kotani H., Hirose M., Menju T., Morishige M., Manabe T., Toda Y., Ishida S. and Sabe H.
    • Journal Title

      PLoS One

      Volume: 6 Issue: 8 Pages: e23359-e23359

    • DOI

      10.1371/journal.pone.0023359

    • NAID

      120003295085

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma2011

    • Author(s)
      Menju T., Hashimoto S., Hashimoto A., Otsuka Y., Handa H., Ogawa E., Toda Y., Wada H., Date H. and Sabe H.
    • Journal Title

      PLoS One

      Volume: 6 Issue: 9 Pages: e25301-e25301

    • DOI

      10.1371/journal.pone.0025301

    • NAID

      120003464637

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] EZH2 regulates Arf6 activity necessary for invasiveness of some breast cancer cells under normoxia and hypoxia2011

    • Author(s)
      橋本茂
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] EZH2 is essential to Arf6 activation necessary for TGFβ1-and hypoxia-induced invasiveness of breast cancer cells2011

    • Author(s)
      橋本茂
    • Organizer
      第70回日本癌学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] EZH2 is essential to Arf6 activation necessary for TGFβ1- and hypoxia-induced invasiveness of breast cancer cells2011

    • Author(s)
      橋本茂
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Arf6 activation under hypoxia and its relationship to invasion, EMT conversion and stemness of breast cancer cells2010

    • Author(s)
      橋本茂
    • Organizer
      第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Arf6 activation under hypoxia and its relationship to invasion, EMT conversion and sternness of breast cancer cells2010

    • Author(s)
      橋本茂
    • Organizer
      BMB 2010
    • Place of Presentation
      神戸ポートアイランド(神戸布)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hypoxia-induced invasive activity of breast cancer cells involves Arf6 activation2010

    • Author(s)
      橋本茂
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Hypoxia-induced invasive activity of breast cancer cells involves Arf6 activation2010

    • Author(s)
      橋本茂
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Book] 乳癌レビュー2012EMT-基礎的観点から2011

    • Author(s)
      橋本あり、杉野弘和、橋本茂、佐邊壽孝
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Final Research Report
  • [Book] 乳癌レビュー2012 EMT-基礎的観点から2011

    • Author(s)
      橋本あり、杉野弘和、橋本茂、佐邊壽孝
    • Total Pages
      7
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.hucc.hokudai.ac.jp/~g21001/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://info.coop.hokudai.ac.jp/bunsei/

    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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