| Project/Area Number |
22657050
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
TANI Tokio 熊本大学, 大学院・自然科学研究科, 教授 (80197516)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,440,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
|---|
| Keywords | 遺伝子発現制御 / 核内構造 / 選択的スプライシング / mRNA 核外輸送 / バイオプローブ / 核スペックル / 核 / 放線菌 / スプライシング因子 / mRNA核外輸送 / バイオロジカルプローブ / mRNA / mRNA品質管理 |
|---|
| Research Abstract |
In eukaryotic cells, the nucleus is highly compartmentalized with dozens of nuclearstructures. Gene expression in the eukaryotic cells is co-ordinately regulated via thosenuclear structures. In this study, we analyzed the mechanisms of the post-transcriptionalregulation of gene expression, such as alternative splicing and nuclear mRNA export,conducted spatiotemporally via the nuclear structures, using the compounds isolated fromcultures of the actinomycetes, which inhibit the formation of the nuclear structures,as biological probes
|
