Study of mechanosensing in the spindle using a 3D force microscope
| Project/Area Number |
22657051
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | The University of Tokyo (2011)
Gakushuin University (2010) |
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Principal Investigator |
YAJIMA Junichiro 東京大学, 大学院・総合文化研究科, 准教授 (00453499)
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| Research Collaborator |
NISHIZAKA Takayuki 学習院大学, 理学部, 教授 (40359112)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,310,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | 微小管 / 分裂期分子モータータンパク質 / メカノセンサー / メカノセンサ / 分裂期分子モーター蛋白質 |
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| Research Abstract |
As a cell changes its shape such as cell division, one of the cytoskeletons, a microtubule, is subject to mechanical stress and responds to mechanical stimulation. These responses may regulate biochemical and mechanical reactions in cell. One way to understand its regulated system is to apply mechanical stress to a microtubule in an in vitro assay and then to quantify motility of molecular motors(kinesins and dyneins) interacted with the microtubule. We constructed microscope systems, which are able to apply mechanical force into the microtubule in 3D dimensions. Using this system, we are examining if a microtubule is mechano-sensor.
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Report
(3 results)
Research Products
(5 results)
