| Project/Area Number |
22658027
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto University |
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Principal Investigator |
OGAWA Jun 京都大学, 大学院・農学研究科, 教授 (70281102)
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| Co-Investigator(Kenkyū-buntansha) |
HIBI Makoto 京都大学, 農学研究科, 助教 (30432347)
HAGISHITA Tairo 京都大学, 農学研究科, 准教授 (20432346)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | 分岐鎖アミノ酸 / 4-ヒドロキシイソロイシン / 肥満 / 糖尿病 / ジオキシゲナーゼ / アルドラーゼ / トランスアミナーゼ / 水酸化アミノ酸 |
|---|
| Research Abstract |
In this study, we attempted to construct novel synthetic procedures for the physiologically active amino acid production, such as hydroxylated branched chain amino acid derivatives, using enzymes involved in newly found microbial branched chain amino acid metabolisms. As the results, streroselectve fine syntheses, such as hydroxylated aliphatic amino acids by dioxygenases, hydroxylated amino acids by aldolases, and 4-hydroxyisoleucine stereoisomers by oxidoreductases were established.
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