Development of functional analysis of secretory lysosomes
| Project/Area Number |
22658036
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
KATAOKA Takao 京都工芸繊維大学, 工芸科学研究科, 准教授 (20242307)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,440,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | 生体分子 / バイオテクノロジー / リソソーム膜タンパク質 / リソソーム / LAMP1 / LIMP2 / バイテクノロジー / 免疫学 / プロテオーム |
|---|
| Research Abstract |
Lysosomes are Organelles essential for the degradation of biological components, and contain soluble acid hydrolases as well as lysosomal membrane proteins.Secretory lysosomes referred to as lytic granules are present in cytotoxic T lymphocytes and natural killer cells. In this study novel molecular probes using lysosomal membrane proteins were constructed for the visualization and purification of secretory lysosomes such as lytic granules and the intracellular localization of these molecular probes on various types of cells was analyzed.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokines.2012
Author(s)
Tamura R, Chen Y, Shinozaki M, Arao K, Wang L, Tang W, Hirano S, Ogura H, Mitsui T, Taketani S, Ando M, Kataoka T.
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: 201222(1)
Issue: 1
Pages: 207-211
DOI
Related Report
Peer Reviewed
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