| Project/Area Number |
22658044
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Food science
|
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,830,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
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| Keywords | 食品機能 / 低分子ペプチド / 生活習慣病 / 機能性食品 / LC-MS / 安定同位体標識 / 腸管吸収 / LC-MS-MS |
|---|
| Research Abstract |
In this study, in order to elucidate effect of the onset of diseases on absorption of bioactive small peptides, a stable isotope labeling LCMRM-MS/MS method forsuccessive determination of peptides in rat blood was primarily developed. By using this newly developed assay method, ca. 2-times higher absorption of one of dipeptides, Trp-His in SHRs was observed for the first time, compared to normal rats.
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