| Project/Area Number |
22658089
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HORI Masatoshi 東京大学, 大学院・農学生命科学研究科, 准教授 (70211547)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,580,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 薬理 / Zn^2 / 肥満細胞 / マクロファージ / 術後腸麻痺 / アレルギー / 炎症 / 平滑筋細胞 / Zn^<2+> |
|---|
| Research Abstract |
In the present study, we established a foundation for a new therapeutic strategy of allergosis of domestic animals and human by using a new zinc ion chelator, IPZ-010, targeting mast cells. In particular, we used mast cells derived post-operative ileus model mice. This animal model can be made in a breeze, in a short period of time, and with high repeatability. Results indicated that IPZ-010 significantly ameliorated inflammation by post-operative ileus with oral or subcutaneous administration via mast cells stabilization.
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