Establishment of in vivo screening system using Medaka fish toward to the drug discovery
| Project/Area Number |
22659002
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TODO Takashi 大阪大学, 医学系・研究科, 教授 (90163948)
YUBA Shunsuke 産業技術総合研究所, セルエンジニアリング研究部門, 主任研究員 (40263248)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | メダカ / 抗がん剤 / 再生医療 / 生物活性物質 / スクリーニング |
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| Research Abstract |
We succeeded in establishing the screening system using Medaka fish to search new medicinal leads that are effective to the animal models. Specifically, we established screening system for searching the bioactive natural products that is able to regulate the re-production of the tail and fins, which reflects the forming of blood and lymphatic vessels. In addition, we have re-discovered marine spongian alkaloid, manzamine A, from our extract library as an inhibitor of re-production of the tail and fins by using established bioassay-guided separation.
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Report
(3 results)
Research Products
(12 results)
