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Novel gene delivery system with switch function

Research Project

Project/Area Number 22659006
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Physical pharmacy
Research InstitutionHokkaido University

Principal Investigator

HARASHIMA Hideyoshi  北海道大学, 大学院・薬学研究院, 教授 (00183567)

Co-Investigator(Kenkyū-buntansha) KAJIMOTO Kazuaki  北海道大学, 大学院・薬学研究院, 特任准教授 (10416216)
HAYASHI Yasuhiro  北海道大学, 大学院・薬学研究院, 特任助教 (30548178)
Co-Investigator(Renkei-kenkyūsha) AKITA Hidetaka  北海道大学, 大学院・薬学研究院, 准教授 (80344472)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords人工遺伝子デリバリーシステム / スイッチ機能 / KALA / DNAワクチン / 非ウイルスベクター / 樹状細胞 / 遺伝子治療 / アジュバント / 遺伝子デリバリー / ウイルスベクター / スイッチ / スイツチ / 細胞内シグナル
Research Abstract

The objective of this study is to develop a novel gene delivery system with a switch function which can interact with target cells to enhance trans geneactivities.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (9 results) (of which Invited: 1 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response2011

    • Author(s)
      Hatakeyama H, Ito E, Yamamoto M, Akita H, Hayashi Y, Kajimoto K, Kaji N, Baba Y, Harashima H
    • Journal Title

      Mol Ther

      Volume: 19(8) Pages: 1487-98

    • NAID

      120003762627

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] KALA-modified multi-layered nano- particles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011

    • Author(s)
      Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
    • Journal Title

      Biomaterials

      Volume: 32(26) Pages: 6342-50

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011

    • Author(s)
      Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
    • Journal Title

      Biomaterials

      Volume: 32(26) Issue: 26 Pages: 6342-6350

    • DOI

      10.1016/j.biomaterials.2011.05.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET.2011

    • Author(s)
      Shaheen SM, Akita H, et al
    • Journal Title

      H.Nucleic Acids Res.

      Volume: (印刷中)

    • NAID

      120002989236

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA microarray analysis of whole blood cells and insulin-sensitive tissues reveals the usefulness of blood RNA profiling as a source of markers for predicting type 2 diabetes.2010

    • Author(s)
      Y.Hayashi, K.Kajimoto, et al
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 33 Pages: 1033-1042

    • NAID

      130000247975

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues.2010

    • Author(s)
      Kajimoto K, Hossen MN, et al
    • Journal Title

      J Immunol Methods.

      Volume: 357 Pages: 43-50

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Technologies in Gene Delivery for Nanomedicines2012

    • Author(s)
      Hideyoshi Harashima, Breakthrough
    • Organizer
      FIP Centennial, 2012
    • Place of Presentation
      Amsterdam, the Netherlands, Amsterdam RAI
    • Year and Date
      2012-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 多機能性エンベロープ型ナノ構造体の創製とナノメディシンへの展開2011

    • Author(s)
      原島秀吉
    • Organizer
      第40回日本免疫学会学術集会関連分野セミナー
    • Place of Presentation
      幕張メッセ(千葉)(招待講演)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 樹状細胞由来細胞を標的としたDNA遺伝子導入システム~DNAワクチンへの応用へ向けて~2011

    • Author(s)
      秋田英万
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)(招待講演)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery: Concept and Application for Nanomedicine2011

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      Joint Meeting of the Austrian and German Pharmaceutical Sciences
    • Place of Presentation
      Innsbruck, Austria, University of Innsbruck
    • Year and Date
      2011-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery : Concept and Application for Nanomedicine2011

    • Author(s)
      Harashima H
    • Organizer
      Joint Meeting of the Austrian and German PharmaceuticalSciences
    • Place of Presentation
      University of Innsbruck (Austria)(招待講演)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] KALA-modified multi-layered nano particles as antigen gene carrier for MHC Class-I mediated antigen presentation in DNA vaccine approach2011

    • Author(s)
      Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yanashita A, Katoono R, Yui N, Harashima H
    • Organizer
      38th Annual Meeting & Exposition of the Controlled Release Society (CRS)
    • Place of Presentation
      Gaylord National Hotel and Convention Center (U.S.A.)
    • Year and Date
      2011-08-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Concept and Application of MEND2010

    • Author(s)
      Hideyoshi Harashima, Nanotechnology for In Vivo Gene Delivery
    • Organizer
      2010 FIP PSWC/AAPS Annual Meeting and Exposition, Short Course: Nanotechnology from A to Z: Achievement in Drug Delivery and Tissue Engineering
    • Place of Presentation
      New Orleans, U. S. A. Ernest N. Morial Convention Center
    • Year and Date
      2010-11-14
    • Related Report
      2012 Final Research Report
  • [Presentation] MENDで拓く創薬への道2010

    • Author(s)
      原島秀吉
    • Organizer
      金沢大学薬学シンポジウム2010創薬動態フォーラムin金沢
    • Place of Presentation
      金沢大学角間キャンパス金沢 招待講演
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Breakthrough Technologies in Gene Delivery for Nanomedicines

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      FIP Centennial, 2012
    • Place of Presentation
      Amsterdam RAI (The Netherlands)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] A Novel Nonviral Gene Delivery System : Multifunctional Envelope-type Nano Device2010

    • Author(s)
      H.Hatakeyama, H.Akita, et al
    • Total Pages
      33
    • Publisher
      T.Scheper, Volume Editors I.Endo and T.Nagamune, Springer
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.hokudai.ac.jp/yakusetu/index.html

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 核内移行性を有する脂質膜構造体2011

    • Inventor(s)
      原島秀吉,秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗、権利者
    • Filing Date
      2011-04-20
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 核移行性を有する脂質膜構造体2011

    • Inventor(s)
      原島秀吉、秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2011-04-10
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 核内移行性を有する脂質膜構造体2010

    • Inventor(s)
      原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学国立大学法人京都大学
    • Filing Date
      2010-04-21
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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