A Challenge to Cerebral Diseases by Nanomedicine
| Project/Area Number |
22659008
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 脳血液関門 / ナノ粒子 / DDS / 超音波 / アルツハイマー / 血液能関門 / ナノゲル / PEG / 脳梗塞再灌流 / アルツハイマー病 / パーキンソン病 |
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| Research Abstract |
The objective of this work was to investigate if our nanoparticles are delivered to brain in order to use them for cerebral disease such as Alzheimer's disease, stroke, cerebral hemorrhage and brain tumors. Two types of nanoparticles were prepared by self-assembling of amphiphilic block copolymers. One of them disintegrate under acidic environment and the other is no-disintegration regardless of pH change. Stable nitroxide radicals were installed in the core of nanoparticles (abbreviation : RNP^N for pH-sensitive and RNP^O for pH-insensitive nanoparticles). In case of RNP^O, 1-2% of nanoparticle was delivered to brain by intravenous administration, while no uptake into blood stream was observed via oral administration. When focused ultrasound was employed along with intravenous administration, accumulation tendency increased one order of magnitude higher. In case of RNP^N, almost the same tendency was observed vie intravenous administration. It is interesting to note that 5-7% of nanoparticle was absorbed in blood stream and a part of them was delivered in brain via oral administration of RNP^N. Oral administration of RNP^N to Alzheimer's disease model mouse worked effectively. Actually, the condition of a disease recovered almost completely by 4 weeks via oral administration of RNP^N.
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Report
(3 results)
Research Products
(68 results)
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[Journal Article] Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid2011
Author(s)
Hiroto Hatakeyama, Hidetaka Akita, Erika Itoh, Yasuhiro Hayashi, Motoi Oishi, Yukio Nagasaki, R.Danev, K.Nagayama, N.Kaji, H.Kikuchi, Y.Baba, Harashima H.
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Journal Title
Biomaterials
Volume: 32(18)
Pages: 4306-4316
Related Report
Peer Reviewed
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[Journal Article] Preparation of Highly Dispersible and Tumor-Accumulative, Iron Oxide Nanoparticles-Multi-point Anchoring of PEG-b-poly(4-vinylbenzylphosphonate) Improves Performance Significantly, Colloid and Surface B2011
Author(s)
Kodai Ujiie, Naoki Kanayama, Kei Asai, Mikio Kishimoto, Yusuke Ohara, Yoshimasa Akashi, Keiichi Yamada, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Hideto Yanagihara, Eiji Kita, Masayuki Yamaguchi, Hirofumi Fujii, Yukio Nagasaki
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Journal Title
Biointreface
Volume: 88
Pages: 771-778
Related Report
Peer Reviewed
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