Identification of a novel GPCR for oxidized LDL and its role in development of arteriosclerosis.
Project/Area Number |
22659013
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
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Research Institution | Tohoku University |
Principal Investigator |
AOKI Junken 東北大学, 大学院・薬学研究科, 教授 (20250219)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
Keywords | 酸化リン脂質 / Gタンパク質共役型受容体 / GPCR / 酸化LDL / リゾホスファチジン酸 / 受容体 / 産生酵素 / ノックアウトマウス |
Research Abstract |
We identified a novel orphan GPCR that reacted specifically with oxidized phospholipids. In this study we further perform biochemical characterization of the GPCR including precise ligand specificity. In addition, we also examine the patho-physiological roles of the GPCR, especially in the development of arteriosclerosis.
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography / electrospray ionizationtandem mass spectrometry2012
Author(s)
Saigusa D, Shiba K, Inoue A, Hama K, Okutani M, Iida N, Saito M, Suzuki K, Kaneko T, Suzuki N, Yamaguchi H, Mano N, Goto J, Hishinuma T, Aoki J, Tomioka Y
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Journal Title
Anal Bioanal Chem.
Volume: 403巻
Pages: 1897-1905
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[Journal Article] GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.2012
Author(s)
Kitamura H, Makide K, Shuto A, Ikubo M, Inoue A, Suzuki K, Sato Y, Nakamura S, Otani Y, Ohwada T, Aoki J
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Journal Title
J. Biochemistry
Volume: 151
Pages: 511-518
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NAID
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[Journal Article] Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish.2011
Author(s)
Yukiura H, Hama K, Nakanaga K, Tanaka M, Asaoka Y, Okudaira S, Arima N, Inoue A, Hashimoto T, Arai H, Kawahara A, Nishina H, Aoki J
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Journal Title
J. Biol. Chem.
Volume: 286
Pages: 43972-43983
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[Journal Article] Serum autotaxin measurements in pregnant women: application for the differentiation of normal pregnancy and pregnancy-induced hypertension2011
Author(s)
Masuda A, Fujii T, Iwasawa Y, Nakamura K, Ohkawa R, Igarashi K, Okudaira S, Ikeda H, Kozuma S, Aoki J, Yatomi Y
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Journal Title
Clin Chim Acta
Volume: 412
Pages: 1944-1950
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[Journal Article] Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptorsFluorescence probe forlysophospholipase C/NPP6 activity and a potent NPP6 inhibitor2011
Author(s)
Mitsuyasu Kawaguchi, Takayoshi Okabe, Shinichi, Okudaira, Kenjiro Hanaoka, Yuuta Fujikawa, Takuya Terai, Toru Komatsu, Hirotatsu Kojima, Junken Aoki, Tetsuo Nagano
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Journal Title
J Am Chem Soc.
Volume: 133
Pages: 12021-12030
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[Journal Article] Specific increase in serum autotaxin activity in patients with pancreatic cancer2011
Author(s)
Nakai Y, Ikeda H, Nakamura K, Kume Y, Fujishiro M, Sasahira N, Hirano K, Isayama H, Tada M, Kawabe T, Komatsu Y, Omata M, Aoki J, Koike K, Yatomi Y
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Journal Title
Clin Biochem
Volume: 44
Pages: 576-581
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[Journal Article] Autotaxin as a novel serum marker of liver fibrosis2011
Author(s)
Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y
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Journal Title
Clin Chim Acta
Volume: 412
Pages: 1201-1206
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[Journal Article] Crystal structure of Autotaxin, a secreted lysophospholipase D that generates GPCR-signaling lipid mediator2011
Author(s)
Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, Ishitani R, Takagi J, Aoki J, Nureki O
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Journal Title
Nature Struct. Mol. Biol.
Volume: 18
Pages: 205-212
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[Journal Article] Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver2010
Author(s)
Takahashi K, Sasabe N, Ohshima K, Kitazato K, Kato R, Masuda Y, Tsurumaki M, Obama T, Okudaira S, Aoki J, Arai H, Yamaguchi T, Itabe H
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Journal Title
J Lipid Res
Volume: 51
Pages: 2571-80
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[Journal Article] A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A(1)in human serum samples2010
Author(s)
Nakamura K, Igarashi K, Ohkawa R, Saiki N, Nagasaki M, Uno K, Hayashi N, Sawada T, Syukuya K, Yokota H, Arai H, Ikeda H, Aoki J, Yatomi Y
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Journal Title
Clin Chim Acta
Volume: 411
Pages: 1090-1094
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[Journal Article] Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts2010
Author(s)
David M, Wannecq E, Descotes F, Jansen S, Deux B, Ribeiro J, Serre CM, Gres S, Bendriss-Vermare N, Bollen M, Saez S, Aoki J, Saulnier-Blache JS, Clezardin P, Peyruchaud O
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[Journal Article] Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis2010
Author(s)
Shinkuma S, Akiyama M, Inoue A, Aoki J, Natsuga K, Nomura T, Arita K, Abe R, Ito K, Nakamura H, Ujiie H, Shibaki A, Suga H, Tsunemi Y, Nishie W, Shimizu H
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Journal Title
Hum Mutat
Volume: 31
Pages: 602-10
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