| Project/Area Number |
22659016
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IRIMURA Tatsuro 東京大学, 大学院・薬学系研究科, 教授 (80092146)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 糖蛋白質 / 正合成 / ゴルジ装置 / ウイルス感染 / 糖鎖 / エボラウイルス / レクチン / グリコシレーション / 糖鎖伸長 / 感染防御 |
|---|
| Research Abstract |
The Ebola virus envelope glycoprotein(GP) determines the infectivity through their differential degree of interaction with MGL, a C-type lectin, and the interaction depends on the carbohydrate structures. Structural determinations of glycans of Zaire GP, Reston GP, and chimeric GPs clearly demonstrated that 18 amino acid residues in the GPs determines the N-glycan extension, particularly transfer of galactose. A possibility that the sequence determines the retention of the glycoprotein at a specific compartment in Golgi apparatus was also shown. Furthermore, importance of specific residues within the 18 amino acids was established.
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