Development of nucleic acid antibody with ADCC activity
| Project/Area Number |
22659020
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
ICHIKAWA Satoshi 北海道大学, 大学院・薬学研究院, 准教授 (60333621)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | 有機化学 / 抗がん / 天然物 / 核酸抗体 / 抗がん剤 / 核酸医薬 / 全合成 / 有機合成化学 |
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| Research Abstract |
First total synthesis of quinaldopeptin has been accomplished via solid-phase peptide synthesis. Namely, the linear decapeptide was sequentially cyclized and attached by chromophores to give quinaldopeptin. It was revealed that quinaldopeptin binds to double-stranded DNA with high affinity. Finally, quinaldopeptin was installed to the double-stranded DNA to afford a nucleic acid antibody with ADCC activity.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Synthesis and Evaluation of 5-Substituted 9-Hydroxypyrrolo[3, 4-c]carbazole-1, 3(2H, 6H)-diones as Check Point 1 Kinase Inhibitors.2010
Author(s)
Sako, Yuki, Osada, Akiko, Ichikawa, Satoshi, Matsuda, Akira
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Journal Title
Bioorg.Med.Chem.
Volume: 18
Pages: 7878-7889
Related Report
Peer Reviewed
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[Journal Article] A new ASST-type sulfotransferase involved in liponucleoside antibiotic biosynthesis in Streptomycetes.2010
Author(s)
Kaysser, Leonard, Eitel, Kornelia, Tanino, Tetsuya, Siebenberg, Stefanie, Matsuda, Akira, Ichikawa, Satoshi, Gust, Bertolt.
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Journal Title
J.Biol.Chem.
Volume: 285
Pages: 12684-12694
Related Report
Peer Reviewed
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