An approach focused on cancer metabolome for overcoming drug resistance

• Project/Area Number: 22659034
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Keio University
• Principal Investigator: NISHIMUTA Akito 慶應義塾大学, 医学部, 特任助教 (00424135)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,070,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: メタボローム / 抗がん剤耐性 / 個別化医療

Research Abstract

This study attempted to elucidate unknown mechanisms of cancer drug resistance and to identify drug resistance determinants by simultaneously analyzing intracellular metabolome of cancer cells resistant to the anticancer agent cisplatin and their parental cells. This study clarified the change of the cancer cell accompanying the acquirement of cisplatin resistance by metabolomic analysis. The knowledge and information obtained by this study will help to elucidate unknown mechanisms of cancer drug resistance.

Research Products

• [Presentation] Metabolomic responses relating to chemosensitivity to oxaliplatin of human colorectal cancer cells (2011)
  • Author(s): 西牟田章戸、杉本昌弘、曽我朋義、谷川原祐介
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-04
• [Presentation] メタボローム解析によるヒト大腸癌細胞のオキサリプラチン感受性バイオマーカー探索 (2011)
  • Author(s): 西牟田章戸、大谷勇紀、杉本昌弘、曽我朋義、谷川原祐介
  • Organizer: 第28回日本TDM学会・学術大会
  • Place of Presentation: 広島国際会議場(広島県)
  • Year and Date: 2011-06-19
• [Presentation] メタボローム解析によるヒト大腸癌細胞のオキサリプラチッ感受性バイオマーカー探索 (2011)
  • Author(s): 西牟田章戸
  • Organizer: 第28回日本TDM学会・学術大会
  • Place of Presentation: 広島国際会議場(広島県)
  • Year and Date: 2011-06-19
• [Presentation] Metabolomics to discover potential biomarkers relating to chemosensitivity to CPT-11 of human colorectal cancer cells (2010)
  • Author(s): 西牟田章戸、杉本昌弘、曽我朋義、谷川原祐介
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-22
• [Patent(Industrial Property Rights)] 抗がん剤感受性の判定マーカー (2012)
  • Inventor(s): 谷川原祐介、西牟田章戸、大谷勇紀、松尾光寿
  • Industrial Property Rights Holder: 学校法人慶應義塾、株式会社ヤクルト本社
  • Filing Date: 2012-02-24
  • Overseas
• [Patent(Industrial Property Rights)] 併用抗がん剤の感受性判定マーカー (2012)
  • Inventor(s): 谷川原祐介、西牟田章戸、津崎盾哉、高橋寛行
  • Industrial Property Rights Holder: 学校法人慶應義塾、株式会社ヤクルト本社
  • Industrial Property Number: 2012-037448
  • Filing Date: 2012-02-23
• [Patent(Industrial Property Rights)] 抗がん剤感受性の判定マーカー (2012)
  • Inventor(s): 谷川原祐介, 西牟田章戸, 大谷勇紀, 松尾光寿
  • Industrial Property Rights Holder: 学校法人慶應義塾株式会社ヤクルト本社
  • Filing Date: 2012-02-24
  • Overseas
• [Patent(Industrial Property Rights)] 併用抗がん剤の感受性判定マーカー (2012)
  • Inventor(s): 谷川原祐介, 西牟田章戸, 津崎盾哉, 高橋寛行
  • Industrial Property Rights Holder: 学校法人慶應義塾株式会社ヤクルト本社
  • Industrial Property Number: 2012-037448
  • Filing Date: 2012-02-23
• [Patent(Industrial Property Rights)] 抗がん剤感受性の判定マーカー (2011)
  • Inventor(s): 谷川原祐介、西牟田章戸、大谷勇紀、松尾光寿
  • Industrial Property Rights Holder: 学校法人慶應義塾、株式会社ヤクルト本社
  • Industrial Property Number: 2011-065993
  • Filing Date: 2011-03-24
• [Patent(Industrial Property Rights)] 抗がん剤感受性の判定マーカー (2011)
  • Inventor(s): 谷川原祐介, 西牟田章戸, 大谷勇紀, 松尾光寿
  • Industrial Property Rights Holder: 学校法人慶應義塾株式会社ヤクルト本社
  • Industrial Property Number: 2011-065993
  • Filing Date: 2011-03-24