An approach focused on cancer metabolome for overcoming drug resistance
| Project/Area Number |
22659034
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,070,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | メタボローム / 抗がん剤耐性 / 個別化医療 |
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| Research Abstract |
This study attempted to elucidate unknown mechanisms of cancer drug resistance and to identify drug resistance determinants by simultaneously analyzing intracellular metabolome of cancer cells resistant to the anticancer agent cisplatin and their parental cells. This study clarified the change of the cancer cell accompanying the acquirement of cisplatin resistance by metabolomic analysis. The knowledge and information obtained by this study will help to elucidate unknown mechanisms of cancer drug resistance.
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Report
(3 results)
Research Products
(10 results)
