| Project/Area Number |
22659039
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Osaka City University |
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Principal Investigator |
IKEDA Kazuo 大阪市立大学, 大学院・医学研究科, 教授 (80275247)
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| Co-Investigator(Renkei-kenkyūsha) |
CHEN Hui 名古屋市立大学, 大学院・医学研究科, 研究員 (70569003)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,030,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | iPS細胞 / 肝星細胞 / 肝細胞 / 肝芽細胞 / HEX / センダイウイルス |
|---|
| Research Abstract |
Induced pluripotent stem(iPS) cells have remarkable potential of differentiating into various cell lineages, including hepatocytes. Hepatocytes induced from iPS cells are expected to have medical applications such as biomedical research, drug study and regenerative medicine. In this study, we tried to induce hepatocyte-like cells from human iPS cells by using hepatic stellate cells as feeder cells, and analyze expression level of Oct3/4, GATA4, alpha-fetoprotein and albumin to compare their properties of differentiation into hepatocytes.
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