• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanical stimulation-induced vascular elastogenesis

Research Project

Project/Area Number 22659045
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionWaseda University

Principal Investigator

MINAMISAWA Susumu  早稲田大学, 理工学術院, 教授 (40257332)

Co-Investigator(Kenkyū-buntansha) TSUNEDA Satoshi  早稲田大学, 理工学術院, 教授 (30281645)
KATO Takashi  早稲田大学, 教育学術院, 教授 (80350388)
IWASAKI Kiyotaka  早稲田大学, 高等研究所, 准教授 (20339691)
KAGAWA Yuki  早稲田大学, ナノ理工学研究機構, 次席研究員 (90409649)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords組織工学 / 形態形成 / 細胞間相互作用 / 機械的刺激 / 弾性線維 / 血管 / 積層化 / 酸素化
Research Abstract

Vascular elastic fibers play a very important role in maintaining the structure of the arteries. The impairment of elastic fiber formation is closely related with aging and vascular diseases. We hypothesized that mecanical stresses onto the arteries would affect elastic fiber formation. Therefore, we tried to perform the quantitative analysis of the relation between elastic fiber formation and the types and strength of mechanical stresses. We found that elastic fiber formation was promoted in multi-layers of smooth muscle cells or by cycle stretch.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (13 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Cardiac origin of smooth muscle cells in the inflow tract2011

    • Author(s)
      Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien KR, Nakano A
    • Journal Title

      J Mol Cell Cardiol

      Volume: 50(2) Pages: 337-45

    • Related Report
      2011 Final Research Report
  • [Journal Article] Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice2010

    • Author(s)
      Wakui H, Tamura K, Matsuda M, Bai Y, Dejima T, Shigenaga AI, Masuda S, Azuma K, Maeda A, Hirose T, Ishigami T, Toya Y, Yabana M, Minamisawa S, Umemura S
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299(5)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Caveolin gene transfer improves glucose metabolism in diabetic mice.2010

    • Author(s)
      Otsu K, Minamisawa S, et al.
    • Journal Title

      Am J Physiol Cell Physiol.

      Volume: 298

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice.2010

    • Author(s)
      Wakui H, Tamura K, Minamisawa S, et al.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac-Specific Activation of Angiotensin II Type 1 Receptor-Associated Protein Completely Suppresses Cardiac Hypertrophy in Chronic Angiotensin II-Infused Mice.2010

    • Author(s)
      Wakui H, Tamura K, Minamisawa S, et al.
    • Journal Title

      Hypertension

      Volume: 55 Pages: 1157-64

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010

    • Author(s)
      Yokoyama U, Minamisawa S, et al.
    • Journal Title

      Circ Res

      Volume: 106 Pages: 1882-92

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 3D cellular muti-layer of rat smooth muscle cells has a potential as a novel ex vivo art erial model2012

    • Author(s)
      石渡遼、横山詩子、門脇功治、松崎典弥、明石満、石川義弘、南沢享
    • Organizer
      The 89TH Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      松本市総合体育館(長野県)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 3D cellular muti-layer of rat smooth muscle cells has a potential as a novel ex vivo arterial model2012

    • Author(s)
      石渡遼、横山詩子、門脇功治、松崎典弥、明石満、石川義弘、南沢享
    • Organizer
      The 89TH Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      松本市総合体育館(長野県)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nov is a novel protein secreted by prostaglandin E2 stimulation from the rat ductus arteriosus2011

    • Author(s)
      岩井謙治、永澤和道、加藤尚志、南沢享
    • Organizer
      The 7th Japan-China-Korea Pediatric Heart Forum
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Three dimensional cellular multi-layer technology utilized evaluation of elastic fiber formation and phenoype of rat vascular smooth muscle cells2011

    • Author(s)
      石渡遼、横山詩子、門脇功治、松崎典弥、明石満、石川義弘、南沢享
    • Organizer
      The 7th Japan-China-Korea Pediatric Heart Forum
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Successful Isolation of Vascular Endothelial Cells from the Rat Ductus Arteriosus.2011

    • Author(s)
      Liu N, Yokota T, Maekawa S, Yokoyama U, Kato T, Minamisawa S.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Thromnoxane A2 Receptor Stimulation Specifically Causes Closure of the Rat Ductus Arteriosus.2011

    • Author(s)
      Aida T, Yokota T, Yokoyama U, Minamisawa S
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epac1 promotes vascular remodeling upon vascular injury in vivo.2011

    • Author(s)
      Kato Y, Yokoyama U, Minamisawa S, Ishikawa Y, et al.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      yokohama, Japan
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serum depletion and three-dimensional multilayer composition induce elastic fiber formation and a contractile phenotype of rat vascular smooth muscle cells.2011

    • Author(s)
      Ishiwata R, Yokoyama U, Minamisawa S, et al.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity.2011

    • Author(s)
      Jiao Q, Akaike T, Takeshima H, Ishikawa Y, Minamisawa S.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] A comprehensive approach to understand the formation of the cardiovascular network (Overview).2011

    • Author(s)
      Minamisawa S
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly.2010

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y., et al.
    • Organizer
      The 84th Scientific Session, American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Counteracting regulation of vascular remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010

    • Author(s)
      Minamisawa S, Yokoyama U, Akaike T, Hammond K, Ishikawa Y.
    • Organizer
      The 16th International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Role of Thromboxane A2 Receptor in the Rat Ductus Arteriosus as a Vasoconstrictor.2010

    • Author(s)
      Yokota T, Ozawa M, Yokoyama U, Minamisawa S.
    • Organizer
      The 16th International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Book] Congenital Heart disease : Recent advances concerning the molecular mechan ism of patent ductus arteriosus2012

    • Author(s)
      Minamisawa S, Yokoyama U
    • Publisher
      InTech
    • Related Report
      2011 Final Research Report
  • [Book] Congenital Heart disease : Recent advances concerning the molecular mechanism of patent ductus arteriosus2012

    • Author(s)
      Minamisawa S, Yokoyama U
    • Total Pages
      348
    • Publisher
      InTech-Open Access Publisher
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://web.mac.com/sminamisawa/set/Welcome.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi