| Project/Area Number |
22659046
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
WAKABAYAHSI Shigeo 独立行政法人国立循環器病研究センター, 研究所, 部長 (70158583)
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| Co-Investigator(Renkei-kenkyūsha) |
HISAMITSU Takashi 独立行政法人国立循環器病研究センター, 研究所, 室長 (50327946)
SHIMADA Naoko (SIMIZU Naoko) 独立行政法人国立循環器病研究センター, 研究所, 流動研究員 (60600385)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,080,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | 生体膜 / チャネル / トランスポーク / 受容体 / 細胞内シグナル伝達 / トランスポータ |
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| Research Abstract |
We found that NHE1 activation by hormones occurs via the lipicHnteracting domain (LID) which functions as a molecular switch. ATP, acidic phospholipids or diacylglycerol (or its potent analogue phorbol ester) directly binds to LID and modulate the NHE1 activity via conformational change of LID. In addition, NHE1 activation was found to promote calcineurin-NEAT signaling pathway via direct interaction of calcineurin with NHE1.
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