| Project/Area Number |
22659049
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kochi University |
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Principal Investigator |
KABA Hideto 高知大学, 教育研究部・医療学系, 教授 (50136371)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | フェロモン / 交尾 / 副嗅球 / 僧帽細胞 / 顆粒細胞 / ホールセルクランプ法 / c-fosプロモーター / ドキシサイクリン / 可視化 / ドキシサイクリン発現調節システム |
|---|
| Research Abstract |
We examined the effects of pharmacological and genetic manipulations of mGluR2, a metabotropic glutamate receptor, on synaptic currents measured from mitral or granule cells in slices of the accessory olfactory bulb(AOB), which is a critical site for mate recognition memory in mice. The results indicate that mGluR2 reduces dendrodendritic inhibition of mitral cells by inhibiting excitatory transmission from mitral cells to granule cells in the AOB. We are currently undertaking an experiment to characterize the properties of mitral and granule cells that store the mate recognition memory.
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