Signaling mechanisms of a novel-type transmembrane receptor 4F2hc

• Project/Area Number: 22659052
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Osaka University
• Principal Investigator: KANAI Yoshikatsu 大阪大学, 大学院・医学系研究科, 教授 (60204533)
• Co-Investigator(Kenkyū-buntansha): NAGAMORI Shushi 大阪大学, 大学院・医学系研究科, 助教 (90467572) ; OHGAKI Ryuichi 大阪大学, 大学院・医学系研究科, 助教 (20467525)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,100,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 受容体 / シグナル情報伝達系 / 輸送体 / 細胞増殖 / リン酸化 / 細胞膜 / チャネル / 輸送系

Research Abstract

To reveal the signaling mechanisms mediated by a single-membrane spanning protein 4F2hc upregulated on cellular activation and in cancer cells, we have analyzed molecular complexes involving 4F2hc, preformed comprehensive signaling-pathway analysis using phosphoproteomics and searched for proteins binding to the intracellular domain of 4F2hc. We have found that 4F2hc together with CD147 forms multimolecular complexes with several transporters, the stimulation of 4F2hc/ LAT1 complex activate mTOR pathway without acting on MAPK pathway and an intracellular domain binding protein mediates 4F2hc signaling.

Research Products

• [Journal Article] Linkage of N-cadherin to Multiple Cytoskeletal Elements Revealed by a Proteomic Approach in Hippocampal Neurons (2012)
  • Author(s): Tanaka H., Takafuji K., Taguchi A., Wiriyasermkul P., Ohgaki R., Nagamori S., Suh P-G., Kanai Y.
  • Journal Title: Neurochem Int Volume: (in press)
  • Peer Reviewed
• [Journal Article] Transport of 3-fluoro-L-α-methyl tyrosine by tumor-pregulated amino acid transporter LAT1 : a cause of the tumor uptake in PET (2012)
  • Author(s): Wiriyasermkul, P. Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R. Tanaka H, Endou H, Endo K, Sakurai H and Kanai Y
  • Journal Title: J Nucl Med Volume: (in press)
  • Peer Reviewed
• [Journal Article] Chronic maternal infusion of full-length adiponectin in pregnant mice downregulates placental amino acid transporter activity and expression and decreases fetal growth (2012)
  • Author(s): Rosario FJ, Schumacher MA, Jiang J, Kanai Y, Powell TL, Jansson T
  • Journal Title: J Physiol Volume: 590 Pages: 1495-1509
  • Peer Reviewed
• [Journal Article] Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis (2012)
  • Author(s): Furuya M, Horiguchi J, Nakajima H, Kanai Y, Oyama T
  • Journal Title: Cancer Sci Volume: 103(2) Pages: 382-389
  • Peer Reviewed
• [Journal Article] Sex hormones induce a gender-related difference in renal expression of a novel prostaglandin transporter, OAT-PG, influencing basal PGE2 concentration (2012)
  • Author(s): Hatano R, Onoe K, Obara M, Matsubara M, Kanai Y, Muto S, Asano S
  • Journal Title: Am J Physiol Renal Physiol Volume: 302(3) Pages: 242-349
  • Peer Reviewed
• [Journal Article] Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growth (2012)
  • Author(s): Rosario FJ, Schumacher MA, Jiang J, Kanai Y, Powell TL, Jansson T
  • Journal Title: J Physiol
  • Peer Reviewed
• [Journal Article] L-type amino acid transporter 1(LAT1) expression in malignant pleural mesothelioma (2011)
  • Author(s): Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
  • Journal Title: Anticancer Res Volume: 31(12) Pages: 4075-4082
  • Peer Reviewed
• [Journal Article] Pathogenic GLUT9 mutations causing renal hypouricemia type 2(RHUC2) (2011)
  • Author(s): Kawamura Y, Matsuo H, Chiba T, Nagamori S, Nakayama A, Inoue H, Utsumi Y, Oda T, Nishiyama J, Kanai Y, Shinomiya N
  • Journal Title: Nucleosides Nucleotides Nucleic Acids Volume: 30(12) Pages: 1105-1111
  • Peer Reviewed
• [Journal Article] Identification of ABCG2 dysfunction as a major factor contributing to gout (2011)
  • Author(s): Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Takada Y, Okada C, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Shinomiya N
  • Journal Title: Nucleosides Nucleotides Nucleic Acids. Volume: 30(12) Pages: 1105-11
  • Peer Reviewed
• [Journal Article] ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans (2011)
  • Author(s): Nakayama A, Matsuo H, Takada T, Ichida K, Nakamura T, Ikebuchi Y, Ito K, Hosoya T, Kanai Y, Suzuki H, Shinomiya N
  • Journal Title: Nucleosides Nucleotides Nucleic Acids. Volume: 30(12) Pages: 1091-7
  • Peer Reviewed
• [Journal Article] Relationship between LAT1 expression and response to platinum-based chemotherapy in non-small cell lung cancer patients with postoperative recurrence (2011)
  • Author(s): Kaira K, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Oriuchi N, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
  • Journal Title: Anticancer Res Volume: 31(11) Pages: 3775-82
  • Peer Reviewed
• [Journal Article] A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans (2011)
  • Author(s): Aoki R, Yagami T, Sasakura H, Ogura K, Kajihara Y, Ibi M, Miyamae T, Nakamura F, Asakura T, Kanai Y, Misu Y, Iino Y, Ezcurra M, Schafer WR, Mori I, Goshima Y
  • Journal Title: J Neurosci. Volume: 31(46) Pages: 16603-10
  • Peer Reviewed
• [Journal Article] LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer (2011)
  • Author(s): Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
  • Journal Title: Am J Transl Res. Volume: 3(5) Pages: 468-78
  • Peer Reviewed
• [Journal Article] Transportsomes and channelsomes : are they functional units for physiological responses? (2011)
  • Author(s): Mori Y, Kiyonaka S, Kanai Y
  • Journal Title: Channels(Austin) Volume: 5(5) Pages: 387-390
  • Peer Reviewed
• [Journal Article] Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis (2011)
  • Author(s): Kurayama R, Ito N, Nishibori Y, Fukuhara D, Akimoto Y, Higashihara E, Ishigaki Y, Sai Y, Miyamoto K, Endou H, Kanai Y, Yan K
  • Journal Title: Lab Invest Volume: 91(7) Pages: 992-1006
  • Peer Reviewed
• [Journal Article] 生体膜トランスポーター研究の現状と展望 (2011)
  • Author(s): 金井好克
  • Journal Title: 膜 Volume: 36 Pages: 128-138
  • NAID: 10029601934
  • Peer Reviewed
• [Journal Article] 開発中の次世代の治療薬: SGLT阻害薬 (2011)
  • Author(s): 金井好克
  • Journal Title: Mebio Volume: 28 Pages: 111-117
  • Peer Reviewed
• [Journal Article] 神経伝達物質トランスポーターの新展開 (2011)
  • Author(s): 金井好克
  • Journal Title: 脳21 Volume: 14 Pages: 302-304
• [Journal Article] L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma (2011)
  • Author(s): Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, 外4名
  • Journal Title: Anticancer Res Pages: 4075-4082
  • Peer Reviewed
• [Journal Article] Pathogenic GLUT9 mutations causing renal hypouricemia type 2 (RHUC2) (2011)
  • Author(s): Kawamura Y, Matsuo H, Chiba T, Nagamori S, Nakayama A, Inoue H, Utsumi Y, Oda T, Nishiyama J, Kanai Y, 外1名
  • Journal Title: Nucleosides Nucleotides Nucleic Acids
  • Peer Reviewed
• [Journal Article] Identification of ABCG2 dysfunction as a major factor contributing to gout (2011)
  • Author(s): Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Takada Y, Okada C, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Shinomiya N
  • Journal Title: Nucleosides Nucleotides Nucleic Acids Pages: 1098-1104
  • Peer Reviewed
• [Journal Article] ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans (2011)
  • Author(s): Nakayama A, Matsuo H, Takada T, Ichida K, Nakamura T, Ikebuchi Y, Ito K, Hosoya T, Kanai Y, Suzuki H, Shinomiya N
  • Journal Title: Nucleosides Nucleotides Nucleic Acids Pages: 1091-1097
  • Peer Reviewed
• [Journal Article] A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans (2011)
  • Author(s): Aoki R, Yagami T, Sasakura H, Ogura K, Kajihara Y, Ibi M, Miyamae T, Nakamura F, Asakura T, Kanai Y, Misu Y, Iino Y, Ezcurra M, Schafer WR, Mori I, Goshima Y
  • Journal Title: J Neurosci Volume: 31 Pages: 16603-16610
  • Peer Reviewed
• [Journal Article] LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer (2011)
  • Author(s): Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, 外4名
  • Journal Title: Am J Transl Res Volume: 3 Pages: 468-478
  • Peer Reviewed
• [Journal Article] Transportsomes and channelsomes : are they functional units for physiological responses? (2011)
  • Author(s): Mori Y, Kiyonaka S, Kanai Y
  • Journal Title: Channels (Austin)
  • Peer Reviewed
• [Journal Article] 開発中の次世代の治療薬:SGLT阻害薬 (2011)
  • Author(s): 金井好克
  • Journal Title: Mebio Volume: 28 Pages: 111-117
• [Journal Article] Delineation of therapeutic significance of transporters as molecular targets of drugs. (2011)
  • Author(s): Kanai Y, He, X, Liu C
  • Journal Title: Asian J of Pharmacodynamics & Pharmacokinetics Volume: 11 Pages: 5-24
  • Peer Reviewed
• [Journal Article] SGLT阻害薬次世代の2型糖尿病薬物治療 (2011)
  • Author(s): 金井好克
  • Journal Title: Mebio Volume: 28 Pages: 111-117
• [Journal Article] Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer. (2010)
  • Author(s): Imai H, Kaira K, Oriuchi N, Shimizu K, Kanai Y, et al.
  • Journal Title: Anticancer Res. Volume: 30 Pages: 4819-4828
  • Peer Reviewed
• [Journal Article] Comparison of L-type amino acid transporter 1 expression and L-[3-18F]-α-methyl tyrosine uptake in outcome of non-small cell lung cancer. (2010)
  • Author(s): Kaira K, Oriuchi N, Shimizu K, Kanai Y, et al.
  • Journal Title: Nucl Med Biol. Volume: 37 Pages: 911-916
  • Peer Reviewed
• [Journal Article] L-type amino-acid transporter 1 expression predicts the response to preoperative hyperthermo-chemoradiotherapy for advanced rectal cancer. (2010)
  • Author(s): Ebara T, Kaira K, Saito J, Shioya M, Kanai Y, et al.
  • Journal Title: Anticancer Res. Volume: 30 Pages: 4223-4227
  • Peer Reviewed
• [Journal Article] Receptor for activated C-kinase 1 regulates the cell surface expression and function of ATP binding cassette G2. (2010)
  • Author(s): Ikebuchi Y, Ito K, Takada T, Anzai N, Kanai Y, Suzuki H.
  • Journal Title: Drug Metab Dispos. Volume: 38 Pages: 2320-2328
  • Peer Reviewed
• [Journal Article] Inhibition of L-type amino acid transporter modulates the expression of cell cycle regulatory factors in KB oral cancer cells. (2010)
  • Author(s): Kim CS, Moon IS, Park JH, Shin WC, Chun, Kanai Y, et al.
  • Journal Title: Biol Pharm Bull. Volume: 33 Pages: 1117-1121
  • NAID: 130000300273
  • Peer Reviewed
• [Journal Article] Drug interaction between celecoxib and methotrexate in organic anion transporter 3-transfected renal cells and in rats in vivo. (2010)
  • Author(s): Maeda A, Tsuruoka S, Ushijima K, Kanai Y, et al.
  • Journal Title: Fur J Pharmacol. Volume: 640 Pages: 168-171
  • NAID: 120007137989
  • Peer Reviewed
• [Journal Article] A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. (2010)
  • Author(s): Shiraya K, Hirata T, Hatano R, Nagamori S, Kanai Y, et al.
  • Journal Title: J Biol Chem. Volume: 285 Pages: 22141-22151
  • Peer Reviewed
• [Journal Article] Properties of L-type amino acid transporter 1 in epidermal ovarian cancer. (2010)
  • Author(s): Kaji M, Kabir-Salmani M, Anzai N, Jin CJ, Kanai Y, et al.
  • Journal Title: Int J Gynecol Cancer Volume: 20 Pages: 329-336
  • Peer Reviewed
• [Journal Article] 癌のアミノ酸トランスポーターと代謝制御(解説/特集)癌の代謝正常組織との代謝特性の違いから見えてくる新たな診断・治療戦略 (2010)
  • Author(s): 金井好克
  • Journal Title: 細胞工学 Volume: 30 Pages: 41-46
• [Journal Article] 薬理学からみた脳卒中関連領域からみた脳卒中(第34回) (2010)
  • Author(s): 金井好克
  • Journal Title: 分子脳血管病 Volume: 9 Pages: 422-429
• [Journal Article] 新たなNa調節系(解説/特集)体液恒常性機構と臨床 (2010)
  • Author(s): 金井好克
  • Journal Title: 腎臓 Volume: 33 Pages: 6-11
• [Journal Article] Role of Amino Acid Transporter LAT2 in the Activation of mTORC1 Pathway and the Pathogenesis of Crescentic Glomerulonephritis
  • Author(s): Kurayama R, Ito N, Nishibori Y, Fukuhara D, Kanai Y, et al.
  • Journal Title: Lab Onvest. Volume: (In press 印刷中)
  • Peer Reviewed
• [Presentation] Proteomics and metabolomics approaches to membrane transporters : Comprehensive analysis of epithelial transport function. (2012)
  • Author(s): 金井好克
  • Organizer: 2012 International Symposium on Pharmacogenomics :" One Step Toward Personalized Medicine"
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-01-30
• [Presentation] Proteomics and metabolomics approaches to membrane transporters : Comprehensive analysis of epithelial transport function (2012)
  • Author(s): 金井好克
  • Organizer: 2012 International Symposium on Pharmacogenomics : "One Step Toward Personalized Medicine"
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2012-01-30
• [Presentation] アミノ酸の細胞取込み機構とエイジング (2012)
  • Author(s): 金井好克
  • Organizer: 第28回臨床フリーラジカル会議
  • Place of Presentation: 亀岡
  • Year and Date: 2012-01-20
• [Presentation] アミノ酸の細胞取込み機構とエイジング (2012)
  • Author(s): 金井好克
  • Organizer: 第28回臨床フリーラジカル会議
  • Place of Presentation: 亀岡(招待講演)
  • Year and Date: 2012-01-20
• [Presentation] アミノ酸誘導体によるトランスポーターを標的とした癌のPET診断と癌抑制薬 (2011)
  • Author(s): 金井好克
  • Organizer: 新アミノ酸分析研究会第一回学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2011-12-09
• [Presentation] アミノ酸誘導体によるトランスポーターを標的とした癌のPET診断と癌抑制薬 (2011)
  • Author(s): 金井好克
  • Organizer: 新アミノ酸分析研究会第一回学術講演会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] 輸送体と疾患 (2011)
  • Author(s): 金井好克
  • Organizer: 第51回茨城腎研究会講演会
  • Place of Presentation: つくば
  • Year and Date: 2011-11-29
• [Presentation] 輸送体と疾患 (2011)
  • Author(s): 金井好克
  • Organizer: 第51回茨城腎研究会講演会
  • Place of Presentation: つくば(招待講演)
  • Year and Date: 2011-11-29
• [Presentation] アミノ酸化合物による腫瘍特異性の高いPET診断とトランスポーター抑制の抗腫瘍効果、ランチョンセミナー「アミノ酸が未来を造る」 (2011)
  • Author(s): 金井好克
  • Organizer: 第33回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2011-11-24
• [Presentation] アミノ酸化合物による腫瘍特異性の高いPET診断とトランスポーター抑制の抗腫瘍効果、ランチョンセミナー「アミノ酸が未来を造る」 (2011)
  • Author(s): 金井好克
  • Organizer: 第33回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 岡山(招待講演)
  • Year and Date: 2011-11-24
• [Presentation] トランスポーターから見た生体膜の薬理学 (2011)
  • Author(s): 金井好克
  • Organizer: 薬理学会北部会新薬理学セミナー
  • Place of Presentation: 仙台(招待講演)
  • Year and Date: 2011-09-30
• [Presentation] 癌のアミノ酸トランスポーターと代謝制御、シンポジウム「がんの代謝制御」 (2011)
  • Author(s): 金井好克
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-24
• [Presentation] 癌のアミノ酸トランスポーターと代謝制御、シンポジウム「がんの代謝制御」 (2011)
  • Author(s): 金井好克
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-09-24
• [Presentation] Usefulness of metabolomics in the analysis of in vivo function of transporters (2011)
  • Author(s): 金井好克
  • Organizer: International Forum on the Development of Traditional Chinese Medicine
  • Place of Presentation: Tianjin, China
  • Year and Date: 2011-09-21
• [Presentation] Usefulness of metabolomics in the analysis of in vivo function of transporters (2011)
  • Author(s): 金井好克
  • Organizer: International Forum on the Development of Traditional Chinese Medicine
  • Place of Presentation: Tianjin, China(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] Metabolomics and proteomics in transporter research in relevance to DMPK study (2011)
  • Author(s): 金井好克
  • Organizer: 2011 ISSX/ CSSX Workshop-Optimization of ADMET/ DMPK Research Capacity
  • Place of Presentation: Tianjin, China
  • Year and Date: 2011-09-18
• [Presentation] Metabolomics and proteomics in transporter research in relevance to DMPKstudy (2011)
  • Author(s): 金井好克
  • Organizer: 2011 ISSX/CSSX Workshop-Optimization of ADMET/DMPK Research Capacity
  • Place of Presentation: Tianjin, China(招待講演)
  • Year and Date: 2011-09-18
• [Presentation] アミノ酸トランスポーターと疾患:特別講演シスチン尿症と悪性腫瘍を中心に (2011)
  • Author(s): 金井好克
  • Organizer: 日本尿路結石症学会第21回学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-08-26
• [Presentation] アミノ酸トランスポーターと疾患:特別講演シスチン尿症と悪性腫瘍を中心に (2011)
  • Author(s): 金井好克
  • Organizer: 日本尿路結石症学会第21回学術集会
  • Place of Presentation: 千葉(招待講演)
  • Year and Date: 2011-08-26
• [Presentation] 網羅的プロテオミクスが明らかにする栄養摂取、病態、加齢等による栄養動態変動の機序 (2011)
  • Author(s): 金井好克
  • Organizer: 第1回生活習慣病予防のための機能性食品開発に関する研究会
  • Place of Presentation: 大阪
  • Year and Date: 2011-07-25
• [Presentation] 網羅的プロテオミクスが明らかにする栄養摂取、病態、加齢等による栄養動態変動の機序 (2011)
  • Author(s): 金井好克
  • Organizer: 第1回生活習慣病予防のための機能性食品開発に関する研究会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-07-25
• [Presentation] "Transportsome", the multimolecular assemblies for transporttransport and transport-metabolism couplings (2011)
  • Author(s): 金井好克
  • Organizer: Symposium Bio-inspired Materials and Functionalities
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2011-06-22
• [Presentation] "Transportsome", the multi-molecular assemblies for transport-transport and transport-metabolism couplings (2011)
  • Author(s): 金井好克
  • Organizer: Symposium Bio-inspired Materials and Functionalities
  • Place of Presentation: Groningen, The Netherlands(招待講演)
  • Year and Date: 2011-06-22
• [Presentation] アミノ酸の細胞への取り込み機構と加齢、シンポジウム「筋萎縮と同化・異化作用」 (2011)
  • Author(s): 金井好克
  • Organizer: 第11回日本抗加齢学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-27
• [Presentation] アミノ酸の細胞への取り込み機構と加齢、シンポジウム「筋萎縮と同化・異化作用」 (2011)
  • Author(s): 金井好克
  • Organizer: 第11回日本抗加齢学会総会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] 悪性腫瘍のトランスポーター:その診断・治療の分子標的としての意義、シンポジウム「トランスポーターからみた医薬品安全性評価」 (2011)
  • Author(s): 金井好克
  • Organizer: 第18回HAB研究機構学術年会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-20
• [Presentation] 悪性腫瘍のトランスポーター:その診断・治療の分子標的としての意義、シンポジウム「トランスポーターからみた医薬品安全性評価」 (2011)
  • Author(s): 金井好克
  • Organizer: 第18回HAB研究機構学術年会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-05-20
• [Presentation] 薬理学からみた脳卒中、ランチョンセミナー (2011)
  • Author(s): 金井好克
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-18
• [Presentation] 薬理学からみた脳卒中、ランチョンセミナー (2011)
  • Author(s): 金井好克
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-05-18
• [Presentation] 特別講演生体膜トランスポーター研究の現状と展望 (2011)
  • Author(s): 金井好克
  • Organizer: 日本膜学会第33年会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-12
• [Presentation] 特別講演生体膜トランスポーター研究の現状と展望 (2011)
  • Author(s): 金井好克
  • Organizer: 日本膜学会第33年会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-05-12
• [Presentation] Tumor imaging and development of potential anti-tumor therapeutics targeting an amino acid transporter. (2011)
  • Author(s): 金井好克
  • Organizer: 4th Asia Pacific Regional ISSX Meeting
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2011-04-23
• [Presentation] Tumor imaging and development of potential anti-tumor therapeutics targeting an amino acid transporter (2011)
  • Author(s): 金井好克
  • Organizer: 4th Asia Pacific Regional ISSX Meeting
  • Place of Presentation: Tainan, Taiwan(招待講演)
  • Year and Date: 2011-04-23
• [Presentation] Transport-metabolism coupling mediated by transportsomes in epithelial cells. (2011)
  • Author(s): 金井好克
  • Organizer: Frontiers in Epithelial Transport 2011
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-15
• [Presentation] Transport-metabolism coupling mediated by transportsomes in epithelial cells., 2011年4月15日、Seoul, Korea (2011)
  • Author(s): 金井好克
  • Organizer: Frontiers in Epithelial Transport 2011
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2011-04-15
• [Presentation] トランスポーターと体内物質動態、シンポジウム「チャネル・トランスポーターによる生体機能制御とその破綻」 (2011)
  • Author(s): 金井好克
  • Organizer: 第28回日本医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-09
• [Presentation] トランスポーターと体内物質動態、シンポジウム「チャネル・トランスポーターによる生体機能制御とその破綻」 (2011)
  • Author(s): 金井好克
  • Organizer: 第28回日本医学会総会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-04-09
• [Presentation] トランスポートソームと上皮輸送 (2011)
  • Author(s): 金井好克
  • Organizer: 日本薬学会第131年会シンポジウム「物質透過を支配する生体バリアとしての上皮の組織構築と機能」
  • Place of Presentation: 静岡市(招待講演)
  • Year and Date: 2011-03-29
• [Presentation] 上皮細胞膜トランスポーターの質量分析による網羅的変動解析手法の確立 (2011)
  • Author(s): 永森収志、高藤和輝、金井好克
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 神奈川県・横浜市
  • Year and Date: 2011-03-22
• [Presentation] A macromolecular complex of URAT1 and OAT4 facilitated by PDZK1 (2010)
  • Author(s): 梅村康浩、福富俊之、永森収志、金井好克
  • Organizer: Biochemistry and Molecular Biology 2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-09
• [Presentation] 腎特異的プロスタグランジン輸送体OAT-PGによる局所PG代謝機構の解析 (2010)
  • Author(s): 波多野亮、永森収志、Pattama Wiriyasermkul、金井好克, 外
  • Organizer: Biochemistry and Molecular Biology 2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-09
• [Presentation] The structural requirements of leucine derivatives to interact with L-type aminoacid transporter 1 (LAT1) and to activate mammalian target of rapamycin (mTOR) (2010)
  • Author(s): Pattama Wiriyasermkul、永森収志、木村徹、大垣隆一、金井好克, 外
  • Organizer: Biochemistry and Molecular Biology 2010
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-07
• [Presentation] The structural requirements of leucine derivatives to be transported by L-type amino acid transporter 1 (LAT1) and to activate mammalian target of rapamycin (mTOR) (2010)
  • Author(s): P.Wiriyasermkul, 永森収志、木村徹、大垣隆一、金井好克
  • Organizer: 第118回日本薬理学会近畿部会
  • Place of Presentation: 大阪府・豊中市
  • Year and Date: 2010-11-19
• [Presentation] 海馬神経細胞接着分子N-cadherin結合蛋白質の網羅的解析 (2010)
  • Author(s): 田中秀和、永森収志、金井好克, 外
  • Organizer: 第118回日本薬理学会近畿部会
  • Place of Presentation: 大阪府豊中市
  • Year and Date: 2010-11-19
• [Presentation] アミノ酸トランスポーター:機能と病態 (2010)
  • Author(s): 金井好克
  • Organizer: 第11回日本毒性病理学会教育セミナー
  • Place of Presentation: 大阪市(招待講演)
  • Year and Date: 2010-11-06
• [Presentation] メタボロミクスを用いた新規有機アニオントランスポーターOatn1の生体内における機能の解析 (2010)
  • Author(s): 永森収志、平田拓、何新、Pattama Wiriyasermkul、石川貴正、曽我朋義、金井好克
  • Organizer: 2010年度生理研研究会
  • Place of Presentation: 愛知県・岡崎市(招待講演)
  • Year and Date: 2010-11-04
• [Presentation] Transporters in medical and pharmaceutical sciences (2010)
  • Author(s): 金井好克
  • Organizer: Lecture in Tianjin University of Traditional Chinese Medicine
  • Place of Presentation: Tianjin, China(招待講演)
  • Year and Date: 2010-11-02
• [Presentation] New aspects of organic anion and drug transporters of SLC22 family (2010)
  • Author(s): 金井好克
  • Organizer: 2010 Shanghai ISSX/CSSX Workshop
  • Place of Presentation: Shanghai China(招待講演)
  • Year and Date: 2010-10-30
• [Presentation] アミノ酸トランスポーターLAT1阻害剤の抗腫瘍効果 (2010)
  • Author(s): 西中由美子、永森収志、遠藤仁、金井好克
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-22
• [Presentation] CE-MS based metabolome analysis in knockout mice reveals real physiological substrates of an organic anion transporter (Invited short talk) (2010)
  • Author(s): 永森収志
  • Organizer: Gordon Research Conference : Membrane Transport Proteins
  • Place of Presentation: 米国・メイン州ビッデフォード(招待講演)
  • Year and Date: 2010-08-17
• [Presentation] 新規塩基性アミノ酸トランスポーターCAT5の機能と構造の解析から解くトランスポーターの基質輸送に伴った構造変化 (2010)
  • Author(s): 永森収志、金井好克, 他
  • Organizer: 第117回日本薬理学会近畿部会
  • Place of Presentation: 徳島県・徳島市
  • Year and Date: 2010-07-08
• [Presentation] アミノ酸・有機酸の膜輸送-分子から生体へ- (2010)
  • Author(s): 金井好克
  • Organizer: 金沢大学薬学シンポジウム2010-創薬動態フォーラムin金沢-
  • Place of Presentation: 金沢(招待講演)
  • Year and Date: 2010-05-28
• [Presentation] 栄養学におけるトランスポーター研究の進歩 (2010)
  • Author(s): 金井好克
  • Organizer: 第64回日本栄養・食糧学会教育講演
  • Place of Presentation: 徳島市(招待講演)
  • Year and Date: 2010-05-23
• [Book] 栄養素トランスポーター：その研究の進展と今後の課題(栄養・食品機能とトランスポーター竹谷豊・薩秀夫・伊藤美紀子・武田英二編) (2011)
  • Author(s): 金井好克
  • Publisher: 建帛社
• [Book] アミノ酸輸送体とその異常(小児腎臓病学 飯島一誠・薩秀夫・関根孝司・金子一成編) (2011)
  • Author(s): 金井好克
  • Publisher: 診断と治療社
• [Book] ハルトナップ(ハートナップ)症候群(症候群ハンドブック 井村裕夫・福井次矢・辻省次編) (2011)
  • Author(s): 金井好克
  • Publisher: 中山書店
• [Book] 栄養・食品機能とトランスポーター:その研究の進展と今後の課題 (2011)
  • Author(s): 金井好克、竹谷豊・薩秀夫・伊藤美紀子・武田英二編
  • Publisher: 建帛社
• [Book] 小児腎臓病学:アミノ酸輸送体とその異常 (2011)
  • Author(s): 金井好克、飯島一誠・薩秀夫・関根孝司・金子一成編
  • Publisher: 診断と治療社
• [Book] 症候群ハンドブック:ハルトナップ(ハートナップ)症候群 (2011)
  • Author(s): 金井好克、井村裕夫・福井次矢・辻省次編
  • Publisher: 中山書店
• [Book] トランスポートソームの世界-膜輸送研究の源流から未来へ- (2011)
  • Author(s): 金井好克(共著)
  • Publisher: 京都廣川書店
• [Book] 遺伝子医学MOOK19号トランスポートソーム:生体膜輸送機構の全体像に迫る-基礎,臨床,創薬応用研究の最新成果 (2011)
  • Author(s): 金井好克(共著)
  • Publisher: メディカルドゥ