Prediction of immune disorders by evaluation of serum IgG reactivity to random peptide library
Project/Area Number |
22659057
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
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Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,010,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,100,000 (Direct Cost: ¥2,100,000)
|
Keywords | 免疫制御 / 抗体 / 自己免疫疾患 / アレルギー / 炎症 / マイクロアレイ / ランダムペプチド / 予防診断技術 / 自然抗体 / プロファイリング |
Research Abstract |
Based on an assumption that reactivities of natural antibodies in sera will be changed before and after onset of immune disorders such as autoimmune diseases, we first analyzed the effect of human polyclonal IgG preparations on immune cell functions such as that of B cells. We found that F(ab')_2 fragment of IgG can bind to various cell surfaces and swiftly internalized into the cytosol. Interestingly, the polyclonal IgG was able to suppress cytokine production from B cells stimulated with CpG.
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcy receptor type Iib-deficient C57BL/6 genetic background.2011
Author(s)
Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
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Journal Title
Arthritis & Rheumatism
Volume: 63
Issue: 10
Pages: 2930-2938
DOI
Related Report
Peer Reviewed
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[Journal Article] Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells2011
Author(s)
Daito H, Kikuchi T, Sakakibara T, Gomi K, Damayanti T, Zaini J, Tode N, Kanehira M, Koyama S, Fujimura S, Ebina M, Ishii KJ, Akira S, Takai T, Watanabe A, Nukiwa T
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Journal Title
Eur Respir J
Volume: 38
Issue: 3
Pages: 688-701
DOI
Related Report
Peer Reviewed
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[Journal Article] An immunoreceptor adapter protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes2011
Author(s)
Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Tchao NK, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lanier LL, Shibuya A
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Journal Title
J. Exp. Med
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] The inhibitory effects of intravenous administration of rabbit IgG on airway inflammation are dependent on Fcgamma receptor IIb on CD11c+ dendritic cells in murine model2010
Author(s)
Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y
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Journal Title
Clin. Exp. Immunol
Volume: 162(2)
Pages: 315-24
Related Report
Peer Reviewed
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[Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney 1ischemia/reperfusion injury2010
Author(s)
Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T
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Journal Title
J. Exp. Med
Volume: 207(7)
Pages: 1501-11
Related Report
Peer Reviewed
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