Bone as an endocrine organ
| Project/Area Number |
22659065
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
HINOI Eiichi 金沢大学, 薬学系, 准教授 (70360865)
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| Co-Investigator(Kenkyū-buntansha) |
TAKARADA Takeshi 金沢大学, 薬学系, 助教 (30377428)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,030,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 骨組織 / 骨芽細胞 / 骨細胞 / growth differentiation factor 15 / ホルモン / 骨代謝 / 破骨細胞 / 骨粗鬆症 / 分泌因子 / 糖代謝 / 内分泌 / 脂質代謝 |
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| Research Abstract |
We identified GDF15 as an endocrine factor secreted from osteocytes. Recombinant GDF15 significantly promoted osteoclastic differentiation. The anti-GDF15 antibody prevented bone loss through inhibiting osteoclastic activation in tibias from mice with femoral artery ligation in vivo. These findings suggest that GDF15 could play a pivotal role in the pathogenesis of bone loss relevant to hypoxia through promotion of osteoclastogenesis after secretion from adjacent osteocytes during disuse and/or ischemia in bone.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Positive regulation of osteoclastic differentiation by growth differentiation factor-15 up-regulated in osteocytic cells under hypoxia2012
Author(s)
Eiichi Hinoi, Hiroki Ochi, Takeshi Takarada, Eri Nakatani, Takashi Iezaki, Hiroko Nakajima, Hiroyuki Fujita, Yoshifumi Takahata, Shinya Hidano, Takashi Kobayashi, Shu Takeda, Yukio Yoneda
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Journal Title
J Bone Miner Res
Volume: 4
Issue: 4
Pages: 938-949
DOI
Related Report
Peer Reviewed
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