| Project/Area Number |
22659065
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
HINOI Eiichi 金沢大学, 薬学系, 准教授 (70360865)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKARADA Takeshi 金沢大学, 薬学系, 助教 (30377428)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,030,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | 骨組織 / 骨芽細胞 / 骨細胞 / growth differentiation factor 15 / ホルモン / 骨代謝 / 破骨細胞 / 骨粗鬆症 / 分泌因子 / 糖代謝 / 内分泌 / 脂質代謝 |
|---|
| Research Abstract |
We identified GDF15 as an endocrine factor secreted from osteocytes. Recombinant GDF15 significantly promoted osteoclastic differentiation. The anti-GDF15 antibody prevented bone loss through inhibiting osteoclastic activation in tibias from mice with femoral artery ligation in vivo. These findings suggest that GDF15 could play a pivotal role in the pathogenesis of bone loss relevant to hypoxia through promotion of osteoclastogenesis after secretion from adjacent osteocytes during disuse and/or ischemia in bone.
|
