| Project/Area Number |
22659067
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The Institute of Physical and Chemical Research (2011)
Osaka University (2010) |
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Principal Investigator |
NAKAJIMA Kazuki 独立行政法人理化学研究所, 糖鎖認識研究チーム, 基幹研究所研究員 (10442998)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 糖ヌクレオチド / 単糖代謝 / 糖鎖 / 質量分析 / クロマトグラフィー / 癌 / 栄養飢餓 |
|---|
| Research Abstract |
We have developed two chromatographic methods for monitoring intracellular nucleotide sugars and their metabolic pathway, to clarify the physiological significance of nucleotide sugars in tumor microenvironments. We examined the changes of nucleotide sugars by glucose deprivation and hypoxic conditions in cancer cell lines, and found that specific reduction of UDP-GlcNAc and UDP-Gal in only pancreatic cancer cell lines influences cellular N-glycan structures.
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