Establishment of the non-invading inspection system for the geriatric disease detects with Maillard reaction products.
| Project/Area Number |
22659068
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Ryoji 日本女子大学, 家政学部, 講師 (20315295)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 糖尿病 / 動脈硬化 / AGE / シグナル増幅反応 / 非侵襲検査 / AGEs / メイラード反応 / CML / 糖化 / ビオチンダイマー / ストレプトアビジン重合体形成 / ビオチントリマー |
|---|
| Research Abstract |
The very-small-quantity protein of the 1 molecular level was detected by the" signal repetition amplifying method" to which each makes two crosslinking agents which have a bridge construction relation react by turns. Condition examination for detecting efficiently the Maillard reaction products for geriatric diseases was performed, and shortening of detection time was realized.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Natural Compounds Containing a Catechol Group Enhance the Formation of N-(carboxymethyl) lysine of the Maillard Reaction2011
Author(s)
Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Mera K, Sakashita N, Takeya M, Ikeda T, Araki T, Nohara T, Nagai R.
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Journal Title
Free Radic. Biol.
Volume: 50(7)
Pages: 883-891
Related Report
Peer Reviewed
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[Journal Article] Renoprotective antioxidant effect of alagebrium in experimental diabetes
Author(s)
Park J, Kwon MK, Huh JY, Choi WJ, Jeong LS, Nagai R, Kim WY, Kim J, Lee TG, Lee HB, Ha H
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Journal Title
Nephrol Dial. Transplant
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting ACAT
Author(s)
Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Horlad H, Ikeda T, Nohara T, Takeya M, Nagai R
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Journal Title
J Agric Food Chem
Volume: (In press)
Related Report
Peer Reviewed
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