| Project/Area Number |
22659069
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | 公益財団法人大阪バイオサイエンス研究所 (2011)
Osaka Bioscience Institute (2010) |
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Principal Investigator |
HIKIDA Takatoshi 公益財団法人大阪バイオサイエンス研究所, システムズ生物学部門, 研究員 (70421378)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 分子病態学 / 大脳基底核 / 薬物依存性 / 黒質網様部 / Eph受容体 / コカイン / 薬物依存症 |
|---|
| Research Abstract |
To analyze neural mechanism of basal ganglia circuit in drug addiction, we developed a reversible neurotransmission blocking technique, in which transmission of the direct and indirect pathways was selectively and reversibly blocked. The results indicated that the coordinated modulation of these two pathways was necessary for acute psychostimulant actions. This modulation, however, shifted to the predominant roles of the direct pathway in the development of drug addiction by repeated exposure of psychostimulants and rewarding learning and the indirect pathway in aversive learning. Furthermore, we have revealed pathway-specific molecular changes in the substantia nigra pars reticulata after cocaine treatment.
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