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Protein processing system-regulating microRNA in gastrointestinal carcinogenesis and its clinical application

Research Project

Project/Area Number 22659074
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionHiroshima University

Principal Investigator

YASUI Wataru  広島大学, 大学院・医歯薬学総合研究科, 教授 (40191118)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,160,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords消化管癌 / 蛋白プロセッシング / マイクロRNA / シグナルペプチダーゼ / 診断.治療 / 診断・治療 / SPC18 / TGFα
Research Abstract

In protein processing system, SPC18, but not SPC21, regulated secretion of EGF and TGFαby cancer cells and activated EGFR. SPC18-positive gastric cancer patients, monitored by immunostaining using anti-SPC18 antibody produced by our laboratory, showed worse prognosis. Down-regulation of miR-143 by DNA methylation regulated TGFβexpression.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (86 results)

All 2012 2011 2010 Other

All Journal Article (36 results) (of which Peer Reviewed: 33 results) Presentation (45 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice Isaka Y and Tsukita S : Deficiency of claudin-18 causes paracellular H+ leakage2012

    • Author(s)
      Hayashi D, Tamura A, Tanaka H, Yamazaki Y, Watanabe S, Suzuki K, Suzuki K, Yasui W, Rakugi H,
    • Journal Title

      up-regulation of interleukin-1beta and atrophic gastritis in mice.

      Volume: 142 Pages: 292-304

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytokeratin expression profiling in gastric carcinoma : clinicopathologic significance and comparison with tumor-associated molecules2012

    • Author(s)
      Takami H
    • Journal Title

      Pathobiology

      Volume: 79 Pages: 154-161

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytokeratin 7 is a predictive marker for survival and effect of adjuvant chemotherapy in patients with esophageal squamous cell carcinoma2012

    • Author(s)
      Oue N
    • Journal Title

      Ann Sure Oncol

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype : Reduction during tumor progression and favorable prognosis2012

    • Author(s)
      Sentani K
    • Journal Title

      Carcinogenesis

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Olfactomedm-4 is a glycoprotein secreted into mucus in active IBD2012

    • Author(s)
      Gersemann M
    • Journal Title

      J Crohns Colitis

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of transmembrane protein in prostate cancer by the Escherichia coli ampicillin secretion trap2011

    • Author(s)
      Hayashi T, Oue N, Sakamoto N, Anami K, Oo HZ, Sentani K, Ohara S, Teishima J, Matsubara A and Yasui W
    • Journal Title

      Expression of CDON is involved in tumor cell growth and invasion. Pathobiology

      Volume: 78 Pages: 277-284

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic mouse model2011

    • Author(s)
      Sumida T, Kitadai Y, Shinagawa K, Tanaka M, Kodama M, Ohnishi M, Ohara E, Tanaka S, Yasui W and Chayama K
    • Journal Title

      Int J Cancer

      Volume: 128 Pages: 2050-2062

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A functional SNP in MUC1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer Short title2011

    • Author(s)
      Saeki N, Saito A, Choi IJ, Matsuo K, Ohnami S, Totsuka H, Chiku S, Kuchiba A, Lee YS, Yoon KA, Kook MC, Park SR, KimYW, Tanaka H, Tajima K, Hirose H, Tanioka F, Matsuno Y, Sugimura H, KatoS, Nakamura T, Nishina T, Yasui W, Aoyagi K, Sasaki H, Yanagihara K, KataiH, Shimoda T, Yoshida T, Nakamura Y, Hirohashi S and Sakamoto H
    • Journal Title

      MUC1is a gastric cancersusceptibility gene. Gastroenterology

      Volume: 140 Pages: 892-902

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A functional SNP in MUC1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer Short title : MUC1 is a gastric cancer susceptibility gene2011

    • Author(s)
      Saeki N
    • Journal Title

      Gastroenterology

      Volume: 140 Pages: 892-902

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic mouse model2011

    • Author(s)
      Sumida T
    • Journal Title

      IntJ Cancer

      Volume: 128 Pages: 2050-2062

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression ofcancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer2011

    • Author(s)
      Wakamatsu Y
    • Journal Title

      Pathol Int

      Volume: 62 Pages: 112-119

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular pathology of gastric cancer : Research and practice2011

    • Author(s)
      Yasui W
    • Journal Title

      Path Res Pract

      Volume: 207 Pages: 608-612

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice2011

    • Author(s)
      Hayashi D
    • Journal Title

      Gastroenterology

      Volume: 142 Pages: 292-304

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] トランスレーショナルリサーチに向けた病理学的研究-消化管がんの新規診断マーカー・治療標的の同定2011

    • Author(s)
      大上直秀
    • Journal Title

      日本薬理学会誌

      Volume: 137 Pages: 146-149

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 消化器癌におけるmicroRNAの意義2011

    • Author(s)
      坂本直也
    • Journal Title

      日本臨床

      Volume: 69 Pages: 103-107

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 網羅的検索から見出した新規腫瘍マーカー2011

    • Author(s)
      大上直秀
    • Journal Title

      Current Therapy

      Volume: 29 Pages: 1109-1112

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic mouse model2011

    • Author(s)
      Sumida T
    • Journal Title

      Int J Cancer

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemoprevention by nonsteroidalanti-inflammatory drug eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis2010

    • Author(s)
      Qui W, Wang X, Leibowitz, Liu H, BarkerN, Okada H, Oue N, Yasui W, Clevers H, Schoen RE, Yu J and Zhang L
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 20027-20032

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium2010

    • Journal Title

      Cancer Res

      Volume: 70 Pages: 6767-6778

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential role for vascular endothelial growth factor-D as anautocrine factor for human gastric carcinoma cells2010

    • Author(s)
      Tanaka M, Kitadai Y, Kodama M, ShinagawaK, Sumida T, Tanaka S, Oue N, Yasui W and Chayama K
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 2121-2127

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of platelet-derived growthfactor(PDGF)-B and PDGF-receptors is associated with lymphatic metastasis in human gastric carcinoma2010

    • Author(s)
      Kodama M, Kitadai Y, Sumida T, OhnishiM, Ohara E, Tanaka M, Shinagawa K, Tanaka S, Yasui W and Chayama K
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 1984-2010

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap2010

    • Author(s)
      Anami K, Oue N, Noguchi T, Sakamoto N, Sentani K, Hayashi T, Hinoi T, OkajimaM, Graff JM and Yasui W
    • Journal Title

      expression of DSC2 ingastric cancer with intestinal phenotype

      Volume: 221 Pages: 275-284

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calin GA and Croce CM : Relation between micro RNAexpression and progression and prognosis of gastric cancer2010

    • Author(s)
      Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Liu CG, Oue N, Yasui W, Yoshida K, Sasaki H, Nomura S, Seto Y, Kaminishi M
    • Journal Title

      a microRNA expression analysis. Lancet Oncol

      Volume: 11 Pages: 136-146

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serial analysis of gene expression of esophageal squamous cell carcinoma2010

    • Author(s)
      Sakamoto N, Oue N, Noguchi T, SentaniK, Anami K, Sanada Y, Yoshida K and Yasui W
    • Journal Title

      ADAMTS16 is up-regulated in esophageal squamous cell carcinoma

      Volume: 101 Pages: 1038-1044

    • NAID

      130004927587

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wnt5a signaling is involvedin aggressiveness of prostate cancer and expression of metalloproteinase2010

    • Author(s)
      Yamamoto H, Oue N, Sato A, Hasegawa Y, Yamamoto H, Matsubara A, Yasui W and Kikuchi A
    • Journal Title

      Oncogene

      Volume: 29 Pages: 2036-2046

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunostaining of gastric cancer with neuroendocrine differentiation : Reg IV-positive neuroendocrine cells are associated with gastrin, serotonin, somatostatin and pancreatic polypeptide2010

    • Author(s)
      Sentani K
    • Journal Title

      Pathol Int

      Volume: 60 Pages: 291-297

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serial analysis of gene expression of esophageal squamous cell carcinoma : ADAMTS16 is up-regulated in esophageal squamous cell carcinoma2010

    • Author(s)
      Sakamoto N
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 1038-1044

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation between microRNA expression and progression and prognosis of gastric cancer : a microRNA expression analysis2010

    • Author(s)
      Ueda T
    • Journal Title

      Lancet Oncol

      Volume: 11 Pages: 136-146

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap : expression of DSC2 in gastric cancer with intestinal phenotype2010

    • Author(s)
      Anami K
    • Journal Title

      J Pathol

      Volume: 221 Pages: 275-284

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cells enhance growth and metastasis of colon cancer2010

    • Author(s)
      Shinagawa K
    • Journal Title

      Int J Cancer

      Volume: 127 Pages: 2323-2333

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of connexin 30 in intestinal phenotype gastric cancer and its reduction during tumor progression2010

    • Author(s)
      Sentani K
    • Journal Title

      Pathobiol

      Volume: 77 Pages: 241-248

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor ss is associated with lymphatic metastasis in human gastric carcinoma2010

    • Author(s)
      Kodama M
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 1984-1989

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma cells2010

    • Author(s)
      Tanaka M
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 2121-2127

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of colorectal cancer with gastric phenotype : Ectopic expression of claudin-18 is associated with poor prognosis2010

    • Author(s)
      Matsuda M
    • Journal Title

      Pathol Int

      Volume: 60 Pages: 673-680

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemoprevention by nonsteroidal anti-inflammatory drug eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis2010

    • Author(s)
      Qui W
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 20027-20032

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype

    • Author(s)
      Sentani K, Oue N, Naito Y, Sakamoto N, Anami K, Oo HZ, Uraoka N, Aoyagi K, Sasaki H and Yasui W
    • Journal Title

      Reduction during tumor progression and favorable prognosis. Carcinogenesis

      Volume: in press

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Molecular characteristics of gastric and intestinal phenotypes of gastric cancer2011

    • Author(s)
      Yasui W
    • Organizer
      The 21^<st> International Symposium of the Hiroshima Cancer Seminar
    • Place of Presentation
      Hiroshima (Japan)(招待講演)
    • Year and Date
      2011-11-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] microRNA-143の胃癌における機能解析と腫瘍マーカーとしての有用性2011

    • Author(s)
      内藤寛、坂本直也、浦岡直礼、仙谷和弘、大上直秀、安井弥
    • Organizer
      第31回日本分子腫瘍マーカー研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃癌におけるSignal peptidase complexのサブユニットSPC18の高発現とその生物学的意義2011

    • Author(s)
      大上直秀、柳原五吉、内藤寛、阿南勝宏、坂本直也、仙谷和弘、安井弥
    • Organizer
      第84回日本胃癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃癌におけるmiR-148aの発現低下とMMP7を介した浸潤への関与2011

    • Author(s)
      坂本直也、内藤寛、仙谷和弘、大上直秀、安井弥
    • Organizer
      第22回日本消化器癌発生学会、ワークショップ3
    • Place of Presentation
      佐賀
    • Related Report
      2011 Final Research Report
  • [Presentation] SEC11AはTGF-aの分泌を促進し、胃癌の進行に関与する2011

    • Author(s)
      安井弥、大上直秀、柳原五吉、仙谷和弘、坂本直也、浦岡直礼、野口剛
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] CAST法を用いた胃癌細胞株における遺伝子発現解析2011

    • Author(s)
      阿南勝宏、大上直秀、坂本直也、林哲太郎、仙谷和弘、浦岡直礼、Htoo Zarni Oo、内藤寛、坂根潤一、後藤景介、野口剛、安井弥
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] Overexpression of SEC11A is associated with tumor progression through TGF-alpha secretion in gastric cancer2011

    • Author(s)
      Oue N, Yanagihara K, Anami K, Sentani K, Sakamoto N, Naito Y and Yasui W
    • Organizer
      8^<th> International Symposium on Minimal Residual Cancer
    • Place of Presentation
      Osaka(Japan)
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of novel diagnostic and therapeutic targets of gastric cancer by transcriptome dissection2011

    • Author(s)
      Yasui W
    • Organizer
      The Third CREAST-SBM International Conference
    • Place of Presentation
      Hiroshima(Japan)
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃癌の発生・進展の分子機序のマイルストーン2011

    • Author(s)
      安井弥
    • Organizer
      第100回日本病理学会総会、シンポジウム1
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃癌におけるmicroRNA発現解析2011

    • Author(s)
      坂本直也、内藤寛、仙谷和弘、大上直秀、安井弥
    • Organizer
      第100回日本病理学会総会、ワークショップ1
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] SAGE-based microarrayにより同定したSEC11A(SPC18)はTGF-aの分泌を促進し胃癌の進行に関連している2011

    • Author(s)
      大上直秀、林哲太郎、柳原五吉、若松雄太、内藤寛、仙谷和弘、坂本直也、安井弥
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Novel diagnostic and therapeutic targets of gastric cancer identified by"Omics"study2011

    • Author(s)
      Yasui W, Sentani K, Sakamoto N, AnamiK, Naito Y and Oue N
    • Organizer
      9^<th> International Gastric Cancer Congress, Symposium 7
    • Place of Presentation
      Seoul(Korea)
    • Related Report
      2011 Final Research Report
  • [Presentation] Gene expression profile in scirrhous type gastric mcancer by CAST method2011

    • Author(s)
      Oo HZ, Uraoka N, Hayashi T, Anami K, Sakamoto N, Sentani K, Oue N and YasuiW
    • Organizer
      9^<th> International Gastric Cancer Congress
    • Place of Presentation
      Seoul(Korea)
    • Related Report
      2011 Final Research Report
  • [Presentation] microRNA expression profiles in gastric cancer : miR-148a is down-regulated in gastric cancer and involved in gastric cancer invasion by repression of MMP7 expression2011

    • Author(s)
      Sakamoto N, Naito Y, Uraoka N, Anami K, Sentani K, Oue N and Yasui W
    • Organizer
      9^<th> International GastricCancer Congress
    • Place of Presentation
      Seoul(Korea)
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular character of gastric and intestinal phenotypes of gastriccancer2011

    • Author(s)
      Yasui W, Oue N, Sentani K, and SakamotoN
    • Organizer
      The 6th International Conference on Gastroenterological Carcinogenesis, Lecture, Houston
    • Place of Presentation
      Texas(USA)
    • Related Report
      2011 Final Research Report
  • [Presentation] Novel diagnostic and therapeutic targets of gastric cancer identified by "Omics" study2011

    • Author(s)
      Yasui W
    • Organizer
      9^<th> International Gastric Cancer Congress
    • Place of Presentation
      Seoul (Korea)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of novel diagnostic and therapeutic targets of gastric cancer by transcriptome dissection2011

    • Author(s)
      Yasui W
    • Organizer
      The Third CREAST-SBM International Conference
    • Place of Presentation
      Hiroshima (Japan)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Overexpression of SEC11A is associated with tumor progression through TGF-alpha secretion in gastric cancer2011

    • Author(s)
      Oue N
    • Organizer
      8^<th> International Symposium on Minimal Residual Cancer
    • Place of Presentation
      Osaka (Japan)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃癌の発生・進展の分子機序のマイルストーン2011

    • Author(s)
      安井弥
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 消化器癌発生・進展と微小環境:SEC11Aの胃癌における高発現とTGF-α/EGF分泌促進作用2011

    • Author(s)
      大上直秀
    • Organizer
      第22回日本消化器癌発生学会
    • Place of Presentation
      佐賀
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular character of gastric and intestinal phenotypes of gastric cancer2011

    • Author(s)
      Yasui W
    • Organizer
      The 6th International Conference on Gastroenterological Carcinogenesis
    • Place of Presentation
      Houston, USA(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌の原発巣と転移巣における粘液形質発現および幹細胞マーカーの免疫組織化学的検討2011

    • Author(s)
      浦岡直礼、安井弥
    • Organizer
      第83回日本胃癌学会総会
    • Place of Presentation
      三沢
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌におけるmicroRNAの網羅的発現解析-miR-148の胃癌組織における発現低下2011

    • Author(s)
      内藤寛、安井弥
    • Organizer
      第83回日本胃癌学会総会
    • Place of Presentation
      三沢
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular basis of intestinal and gastric phenotypes of gastriccancer2010

    • Author(s)
      Yasui W
    • Organizer
      The 17^<th> Seoul International Cancer Symposium"Gastric Cancer Update 2010"
    • Place of Presentation
      Seoul(Korea)
    • Year and Date
      2010-06-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular basis of intestinal and gastric phenotypes of gastric cancer2010

    • Author(s)
      Yasui W
    • Organizer
      The 17^<th> Seoul International Cancer Symposium "Gastric Cancer Update 2010"
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2010-06-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] トランスクリプトーム解析による新規診断標的の同定とがん病理診断への応用2010

    • Author(s)
      安井弥
    • Organizer
      第69回日本癌学会学術総会シンポジウム5
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃癌におけるmicroRNA発現解析:miR-148aの胃癌組織における発現低下.2010

    • Author(s)
      安井弥、内藤寛、仙谷和弘、大上直秀、安井弥
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃癌における細胞表面蛋白質desmocollin2の解析2010

    • Author(s)
      大上直秀、阿南勝宏、内藤寛、坂本直也、仙谷和弘、安井弥
    • Organizer
      第19回日本がん転移学会学術集会・総会ミニシンポジウム(2)
    • Place of Presentation
      金沢
    • Related Report
      2011 Final Research Report
  • [Presentation] ホルマリン固定パラフィン包埋(FFPE)標本を用いた胃癌におけるmicroRNA発現解析2010

    • Author(s)
      坂本直也、内藤寛、仙谷和弘、大上直秀、安井弥
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Desmocollin 2(DSC2), identified by CAST method, is associated with intestinal phenotype of gastric cancer2010

    • Author(s)
      Anami K, Oue N, Sakamoto N, Hayashi T, Ohara S, Sentani K, Noguchi T and Yasui W
    • Organizer
      The 101st Annual Meeting of the American Association for Cancer Research, Washington D. C.
    • Place of Presentation
      Maryland(USA)
    • Related Report
      2011 Final Research Report
  • [Presentation] Desmocollin 2 (DSC2), identified by CAST method, is associated with intestinal phenotype of gastric cancer2010

    • Author(s)
      Anami K, Yasui w
    • Organizer
      The 101st Annual Meeting of the American Association for Cancer Research
    • Place of Presentation
      Washington D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serial Analysis of gene expression (SAGE) of esophageal squamous cell carcinoma : ADAMTS-16 is up-regulated in esophageal squamous cell carcinoma2010

    • Author(s)
      Sakamoto N, Yasui W
    • Organizer
      The 101st Annual Meeting of the American Association for Cancer Research
    • Place of Presentation
      Washington D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunohistochemical analysis of colorectal cancer with gastric phenotype : claudin-18 is associated with poor prognosis2010

    • Author(s)
      Sentani K, Yasui W
    • Organizer
      The 198th Scientific Meeting of the Pathological Society of Great Britain & Ireland
    • Place of Presentation
      St Andrews (Scotland), UK
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel diagnostic and therapeutic targets of gastrointestinal cancer identified by "Omics" study2010

    • Author(s)
      Yasui W
    • Organizer
      The 9^<th> International Conference of the Asian Clinical Oncology Society
    • Place of Presentation
      Gifu, Japan(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌におけるDSC2発現と腸型粘液形質との関係2010

    • Author(s)
      阿南勝宏、安井弥
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 遺伝子発現プロファイルで同定したHOXA10の胃癌腸型形質との関連2010

    • Author(s)
      仙谷和弘、安井弥
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] SAGE法を用いた食道扁平上皮癌の新規マーカーADAMTS16の同定2010

    • Author(s)
      浦岡直礼、安井弥
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Wnt-5aはlaminin γ2の発現を誘導し、胃癌細胞の浸潤を促進する2010

    • Author(s)
      大上直秀、安井弥
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌におけるMMP-7とlaminin γ2の発現と臨床病理学的意義2010

    • Author(s)
      本下潤一、安井弥
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] トランスクリプトーム解析による新規診断標的の同定とがん病理診断への応用2010

    • Author(s)
      安井弥
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌におけるmicroRNA発現解析:miR-148aの胃癌組織における発現低下2010

    • Author(s)
      坂本直也、安井弥
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 原爆被爆者に発生した胃癌におけるmicroRNA発現解析2010

    • Author(s)
      浦岡直礼、安井弥
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌における原発巣とリンパ節転移巣の粘液形質発現の比較2010

    • Author(s)
      若松雄太、安井弥
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌組織を用いたCAST法による胃癌の新たなバイオマーカーの探索2010

    • Author(s)
      安井弥
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] CAST法で同定された胃型胃癌関連分子TSPAN8の解析2010

    • Author(s)
      阿南勝宏、安井弥
    • Organizer
      第21回日本消化器癌発生学会総会
    • Place of Presentation
      軽井沢
    • Related Report
      2010 Annual Research Report
  • [Book] Principle of molecular diagnostics and personalized cancer therapy2012

    • Author(s)
      Yasui W
    • Publisher
      Lippincott Williams & Wilkins(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] スキルス胃癌-基礎と臨床-改訂版2010

    • Author(s)
      安井弥、本下潤一、大上直秀
    • Total Pages
      435
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/byori1/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/byori1/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/byori1/kenkyu_gyouseki.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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