Novel Complementary Peptides Control Inflammatory Responses
| Project/Area Number |
22659081
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
OKADA Noriko 名古屋市立大学, 大学院・医学研究科, 教授 (20160682)
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Masaki 名古屋市立大学, 大学院・医学研究科, 講師 (30440936)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,360,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | アナフィラトキシン C5a / エンドトキシンショック / 補体 / アナフィラトキシン / アナフィラトキシンC5a / 全身性炎症反応症候群 / 全身性炎症反応症候群(SIRS) |
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| Research Abstract |
C5a anaphylatoxin is considered to be an effective target for treatment of hyperinflammation since C5a stimulates neutrophils and endothelial cells, then generation of tumor necrosis factor alpha (TNFα) and other inflammatory cytokines. To clear how C5a induces to serious inflammatory responses, we generated C5a inhibitory peptides with an evolutionary computer program that generates complementary peptide (C-pep) sequences. We showed that a novel C5a C-peptide, AcpepA significantly improved an injury score compared to PBS control on rat model with brain ischemia and reperfusion injury.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Endothelin Receptor Antagonist Attenuates Oxidative Stress in Neonatal Sepsis Model2012
Author(s)
Goto T, Hussein MH, Kato S, Daoud GA, Kato T, Sugiura T, Kakita H, Nobata M, Kamei M, Mizuno H, Imai M, Ito T, Kato I, Suzuki S, Okada N, Togari H, Okada H
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Journal Title
Pediatric Research
Volume: 72
Pages: 600-605
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[Journal Article] Guideline for Hereditary Angioedema (HAE) 2010 by the Japanase Association for Complement Research - Secondary Publication2012
Author(s)
Horiuchi T., Ohi H., Ohsawa I., Fujita T., Matsushita M., Okada N., Seya T., Yamamoto T., Endo Y., Hatanaka M., Wakamiya N., Matsumoto M., Inoue N., Nonaka M., Kinoshita T
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Journal Title
Allegology Int
Volume: 61
Pages: 559-562
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[Journal Article] Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication2012
Author(s)
Horiuchi T, Ohi H, Ohsawa I, Fujita T,Matsushita M, Okada N, Seya T,Yamamoto T, Endo Y, Hatanaka M,Wakamiya N, Mizuno M, Nakao M, OkadaH, Tsukamoto H, Matsumoto M, Inoue N,Nonaka M, Kinoshita T.
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Journal Title
Allergology International
Volume: 61
Issue: 4
Pages: 559-562
DOI
NAID
ISSN
1323-8930, 1440-1592
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Peer Reviewed
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[Journal Article] Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy2011
Author(s)
Ito Y, Torii Y, Ohta R, Imai M, Hara S, Kawano Y, Matsubayashi T, Inui A, Yoshikawa T, Nishimura N, Ozaki T, Morishima T, Kimura H
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Journal Title
in 2009 H1N1 influenza-infected children. Cytokine
Volume: 56
Pages: 180-187
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[Journal Article] Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model2010
Author(s)
Goto T, Hussein MH, Kato S, Daoud GA, Kato T, Sugiura T, Kakita H, Nobata M, Mizuno H, Imai M, Ito T, Kato I, Suzuki S, Okada N, Togari H, Okada H
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Journal Title
Eur J Intensive Care Med
Volume: 36(12)
Pages: 2132-2139
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[Presentation] C5a is a target to prevent peritoneal tissue damage in acute peritoneal injury in rats2012
Author(s)
Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Yamada K, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y
Organizer
XXIV International Complement Workshop
Place of Presentation
Crete, Greece, Immunobiology
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[Presentation] 急性腹膜生涯に対するアンチセンス C5a ペプチドの治療効果2012
Author(s)
水野智博, 水野正司, 櫛田真由, 野田幸裕, 山田清文, 今井優樹, 岡田秀親, 岡田則子, 丸山彰一, 松尾清一, 伊藤恭彦
Organizer
第49回補体シンポジウム
Place of Presentation
大阪成人病センター(大阪)
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[Presentation] 急性腹膜障害に対する C5a の関与と C5a 阻害薬の有用性2011
Author(s)
水野智博, 水野正司, 櫛田真由, 野田幸裕, 山田清文, 今井優樹, 岡田秀親, 岡田則子, 丸山彰一, 松尾清一, 伊藤恭彦
Organizer
第48回補体シンポジウム
Place of Presentation
名古屋市立大学医学部(名古屋)
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[Book] 補体への招待2011
Author(s)
今井優樹, 岡田則子, 他
Total Pages
231
Publisher
メジカルビュー社
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