| Project/Area Number |
22659081
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
OKADA Noriko 名古屋市立大学, 大学院・医学研究科, 教授 (20160682)
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Masaki 名古屋市立大学, 大学院・医学研究科, 講師 (30440936)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,360,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | アナフィラトキシン C5a / エンドトキシンショック / 補体 / アナフィラトキシン / アナフィラトキシンC5a / 全身性炎症反応症候群 / 全身性炎症反応症候群(SIRS) |
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| Research Abstract |
C5a anaphylatoxin is considered to be an effective target for treatment of hyperinflammation since C5a stimulates neutrophils and endothelial cells, then generation of tumor necrosis factor alpha (TNFα) and other inflammatory cytokines. To clear how C5a induces to serious inflammatory responses, we generated C5a inhibitory peptides with an evolutionary computer program that generates complementary peptide (C-pep) sequences. We showed that a novel C5a C-peptide, AcpepA significantly improved an injury score compared to PBS control on rat model with brain ischemia and reperfusion injury.
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