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Novel Complementary Peptides Control Inflammatory Responses

Research Project

Project/Area Number 22659081
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionNagoya City University

Principal Investigator

OKADA Noriko  名古屋市立大学, 大学院・医学研究科, 教授 (20160682)

Co-Investigator(Kenkyū-buntansha) IMAI Masaki  名古屋市立大学, 大学院・医学研究科, 講師 (30440936)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,360,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
Keywordsアナフィラトキシン C5a / エンドトキシンショック / 補体 / アナフィラトキシン / アナフィラトキシンC5a / 全身性炎症反応症候群 / 全身性炎症反応症候群(SIRS)
Research Abstract

C5a anaphylatoxin is considered to be an effective target for treatment of hyperinflammation since C5a stimulates neutrophils and endothelial cells, then generation of tumor necrosis factor alpha (TNFα) and other inflammatory cytokines. To clear how C5a induces to serious inflammatory responses, we generated C5a inhibitory peptides with an evolutionary computer program that generates complementary peptide (C-pep) sequences. We showed that a novel C5a C-peptide, AcpepA significantly improved an injury score compared to PBS control on rat model with brain ischemia and reperfusion injury.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (57 results)

All 2013 2012 2011 2010

All Journal Article (24 results) (of which Peer Reviewed: 12 results) Presentation (30 results) Book (3 results)

  • [Journal Article] Interleukin-17A-Producing T Lymphocytes in Chronic Active Epstein-Barr Virus Infection2013

    • Author(s)
      Ohta R, Imai M, Kawada J, Kimura H, Ito Y
    • Journal Title

      Microbiol. Immunol

      Volume: 57 Pages: 139-144

    • NAID

      40019591291

    • Related Report
      2012 Final Research Report
  • [Journal Article] Interleukin-17A-Producing T Lymphocytes in Chronic Active Epstein-Barr Virus Infection.2013

    • Author(s)
      Ohta R
    • Journal Title

      Microbiology and Immunology

      Volume: 57 Issue: 2 Pages: 139-144

    • DOI

      10.1111/1348-0421.12010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin Receptor Antagonist Attenuates Oxidative Stress in Neonatal Sepsis Model2012

    • Author(s)
      Goto T, Hussein MH, Kato S, Daoud GA, Kato T, Sugiura T, Kakita H, Nobata M, Kamei M, Mizuno H, Imai M, Ito T, Kato I, Suzuki S, Okada N, Togari H, Okada H
    • Journal Title

      Pediatric Research

      Volume: 72 Pages: 600-605

    • Related Report
      2012 Final Research Report
  • [Journal Article] Liposits Z. Estrogen receptor alpha and beta differentially mediate C5aR agonist evoked Ca-influx in neurons through L-type voltage-gated Ca channels2012

    • Author(s)
      Farkas I., Sarvari M., Aller M., Okada N., Okada H., Liko I.
    • Journal Title

      Neurochem. Int

      Volume: 60 Pages: 631-639

    • Related Report
      2012 Final Research Report
  • [Journal Article] Membrane complement regulators protect against fibrin exudation increases in a severe peritoneal inflammation model in rats.2012

    • Author(s)
      Mizuno M., Ito Y., Harris CL., Suzuki Y., Okada N., Matsuo S., Morgan BP
    • Journal Title

      Am. J. Physiol. Phaemacol

      Volume: 302

    • Related Report
      2012 Final Research Report
  • [Journal Article] Guideline for Hereditary Angioedema (HAE) 2010 by the Japanase Association for Complement Research - Secondary Publication2012

    • Author(s)
      Horiuchi T., Ohi H., Ohsawa I., Fujita T., Matsushita M., Okada N., Seya T., Yamamoto T., Endo Y., Hatanaka M., Wakamiya N., Matsumoto M., Inoue N., Nonaka M., Kinoshita T
    • Journal Title

      Allegology Int

      Volume: 61 Pages: 559-562

    • Related Report
      2012 Final Research Report
  • [Journal Article] C 型慢性肝炎の治療薬開発を通してみた国内外の臨床試験検索サイトの活用方法の模索2012

    • Author(s)
      牧江俊雄,黒田祥平,中村 剛,今井優樹,森永 紀,北谷 和之
    • Journal Title

      医薬品医療機器レギュラトリーサイエンス

      Volume: 43 Pages: 446-451

    • Related Report
      2012 Final Research Report
  • [Journal Article] Endothelin Receptor Antagonist Attenuates Oxidative Stress in Neonatal Sepsis Model.2012

    • Author(s)
      Goto T
    • Journal Title

      Pediatric Research

      Volume: 72 Issue: 6 Pages: 600-605

    • DOI

      10.1038/pr.2012.134

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptor alpha and beta differentially mediate C5aR agonist evoked Ca-influx in neurons through L-type voltage-gated Ca channels.2012

    • Author(s)
      Farkas I
    • Journal Title

      Neurochem. Int.

      Volume: 60 Issue: 6 Pages: 631-619

    • DOI

      10.1016/j.neuint.2012.02.024

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane complement regulators protect against fibrin exudation increases in a severe peritoneal inflammation model in rats.2012

    • Author(s)
      Mizuno M
    • Journal Title

      Am. J. Physiol. Phaemacol.

      Volume: 302 Issue: 10 Pages: F1245-F1251

    • DOI

      10.1152/ajprenal.00652.2011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication2012

    • Author(s)
      Horiuchi T, Ohi H, Ohsawa I, Fujita T,Matsushita M, Okada N, Seya T,Yamamoto T, Endo Y, Hatanaka M,Wakamiya N, Mizuno M, Nakao M, OkadaH, Tsukamoto H, Matsumoto M, Inoue N,Nonaka M, Kinoshita T.
    • Journal Title

      Allergology International

      Volume: 61 Issue: 4 Pages: 559-562

    • DOI

      10.2332/allergolint.12-RAI-0471

    • NAID

      130004873058

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy2011

    • Author(s)
      Ito Y, Torii Y, Ohta R, Imai M, Hara S, Kawano Y, Matsubayashi T, Inui A, Yoshikawa T, Nishimura N, Ozaki T, Morishima T, Kimura H
    • Journal Title

      in 2009 H1N1 influenza-infected children. Cytokine

      Volume: 56 Pages: 180-187

    • Related Report
      2012 Final Research Report
  • [Journal Article] Novel Complementary Peptides to Target Molecules2011

    • Author(s)
      Okada H, Imai M, Ono F, Okada A, TadaT, Mizue Y, Terao K, Okada N
    • Journal Title

      Anticancer Res

      Volume: 31 Pages: 2511-2516

    • Related Report
      2012 Final Research Report
  • [Journal Article] Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza.2011

    • Author(s)
      Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y
    • Journal Title

      Microbiol. Immunol

      Volume: 55(3) Pages: 191-198

    • NAID

      10031121459

    • Related Report
      2012 Final Research Report
  • [Journal Article] 腫瘍の補体制御膜因子による免疫回避2011

    • Author(s)
      今井優樹, 岡田則子
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56 Pages: 31-37

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Novel Complementary Peptides to Target Molecules2011

    • Author(s)
      Okada H, Imai M, Ono F, Okada A, Tada T, Mizue Y, Terao K, Okada N
    • Journal Title

      Anticancer Research

      Volume: 31 Pages: 2511-2516

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza2011

    • Author(s)
      Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y
    • Journal Title

      Microbiology and Immunology

      Volume: 55 Pages: 191-198

    • NAID

      10031121459

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza.2011

    • Author(s)
      Ohta R
    • Journal Title

      Microbiology and Immunology

      Volume: 55 Pages: 191-198

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation2011

    • Author(s)
      Mizuno T
    • Journal Title

      Nephrol Dial Transplant

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model2010

    • Author(s)
      Goto T, Hussein MH, Kato S, Daoud GA, Kato T, Sugiura T, Kakita H, Nobata M, Mizuno H, Imai M, Ito T, Kato I, Suzuki S, Okada N, Togari H, Okada H
    • Journal Title

      Eur J Intensive Care Med

      Volume: 36(12) Pages: 2132-2139

    • Related Report
      2012 Final Research Report
  • [Journal Article] Procarboxypeptidase R Deficiency Causes Increased Lethality in Concanavalin A -induced Hepatitis in Female Mice2010

    • Author(s)
      Asai S, Kimbara N, Tada T, Imai M*, Campbell W, Okada H, Okada N
    • Journal Title

      Biol Pharm Bull

      Volume: 33 Pages: 1256-1259

    • NAID

      130000300299

    • Related Report
      2012 Final Research Report
  • [Journal Article] Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model.2010

    • Author(s)
      Goto T
    • Journal Title

      Intensive Care Medicine

      Volume: 36 Pages: 2132-2139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Procarboxypeptidase R Deficiency Causes Increased Lethality in Concanavalin A -induced Hepatitis in Female Mice.2010

    • Author(s)
      Asai S
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 33 Pages: 1256-1259

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of the cross-talk between the complement and coagulation cascades by C5a blockade improves early outcomes after intraportalislet transplantation2010

    • Author(s)
      Tokodai T
    • Journal Title

      Transplantation

      Volume: 90 Pages: 1358-1365

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Enhancing antibody immunotherapy by orally administered herbal medicine Juzen-taiho-to2012

    • Author(s)
      Imai M, Ohta R, Okada N
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2012 Final Research Report
  • [Presentation] C5a is a target to prevent peritoneal tissue damage in acute peritoneal injury in rats2012

    • Author(s)
      Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Yamada K, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y
    • Organizer
      XXIV International Complement Workshop
    • Place of Presentation
      Crete, Greece, Immunobiology
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌に対する抗 MUC1 モノクローナル抗体の抗腫瘍活性と補体膜制御因子の影響2012

    • Author(s)
      今井優樹, 太田里永子、岡田則子
    • Organizer
      第49回補体シンポジウム
    • Place of Presentation
      大阪成人病センター(大阪)
    • Related Report
      2012 Final Research Report
  • [Presentation] 急性腹膜生涯に対するアンチセンス C5a ペプチドの治療効果2012

    • Author(s)
      水野智博, 水野正司, 櫛田真由, 野田幸裕, 山田清文, 今井優樹, 岡田秀親, 岡田則子, 丸山彰一, 松尾清一, 伊藤恭彦
    • Organizer
      第49回補体シンポジウム
    • Place of Presentation
      大阪成人病センター(大阪)
    • Related Report
      2012 Final Research Report
  • [Presentation] C5a is a target to prevent peritoneal tissue damage in acute peritoneal injury in rats.2012

    • Author(s)
      Mizuno T
    • Organizer
      XXIV International Complement Workshop
    • Place of Presentation
      Minoa Palace Conference Center (Crete, Greece)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Enhancing antibody immunotherapy by orally administered herbal medicine Juzen-taiho-to.2012

    • Author(s)
      Imai M
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 口腔癌に対する抗MUC1モノクローナル抗体の抗腫瘍活性と補体膜制御因子の影響2012

    • Author(s)
      今井優樹
    • Organizer
      第49回補体シンポジウム
    • Place of Presentation
      大阪府立成人病センター(大阪)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性腹膜生涯に対するアンチセンスC5aペプチドの治療効果2012

    • Author(s)
      水野智博
    • Organizer
      第49回補体シンポジウム
    • Place of Presentation
      大阪府立成人病センター(大阪)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza.2011

    • Author(s)
      Imai M, Ohta R, Okada N
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Inactivation of C5a anaphylatoxin is an effective treatment of sepsis2011

    • Author(s)
      Okada N, Imai M, Goto T, Hamed M, Okada A, Ono F, Okada H
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2012 Final Research Report
  • [Presentation] H1N1 インフルエンザの重症化における補体アナフィラトキシン及び HMGB1 の関与2011

    • Author(s)
      太田里永子, 伊藤嘉規, 鳥居ゆか, 木村宏, 岡田則子, 今井優樹
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋市立大学医学部(名古屋)
    • Related Report
      2012 Final Research Report
  • [Presentation] プロカルボキシペプチダーゼ R 欠損はコンカナバリン A 誘発性肝炎による致死率を雌マウスにおいて増大させる2011

    • Author(s)
      朝井鈴佳、金原紀章、多田豊廣、今井優樹、Campbell W, 岡田秀親、岡田則子
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋市立大学医学部(名古屋)
    • Related Report
      2012 Final Research Report
  • [Presentation] 急性腹膜障害に対する C5a の関与と C5a 阻害薬の有用性2011

    • Author(s)
      水野智博, 水野正司, 櫛田真由, 野田幸裕, 山田清文, 今井優樹, 岡田秀親, 岡田則子, 丸山彰一, 松尾清一, 伊藤恭彦
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋市立大学医学部(名古屋)
    • Related Report
      2012 Final Research Report
  • [Presentation] Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza2011

    • Author(s)
      Imai M, Ohta R, Okada N
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inactivation of C5a anaphylatoxin is an effective treatment of sepsis2011

    • Author(s)
      Okada N, Imai M, 他
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Trypanosoma brucei brucei昆虫型原虫のラット正常血清による溶解2011

    • Author(s)
      籔義貞, 伊藤奈緒子, 高岡大樹, 岡田則子
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋市立大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] カルボキシペプチダーゼR生成を阻害する相補性ペプチド2011

    • Author(s)
      河村剛至、堀川康一郎、岡田秀親、岡田則子
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋市立大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 島移植におけるC5a阻害ペプチドの作用機序に関する検証2011

    • Author(s)
      中西渉、後藤昌史、稲垣明子、戸子台和哲、岡田則子、岡田秀親、里見進
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋市立大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] An acetylated anti-C5a complementary peptide reduced cytokines storm and prolonged survival time in a neonatal sepsis model2011

    • Author(s)
      Hussein MH, Daoud GAH, Okada N, 他
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋市立大学(愛知県)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] H1N1インフルエンザの重症化における補体アナフィラトキシン及びHMGB1の関与2011

    • Author(s)
      太田里永子, 伊藤嘉規, 鳥居ゆか, 木村宏, 岡田則子, 今井優樹
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋市立大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロカルボキシペプチダーゼR欠損はコンカナバリンA誘発性肝炎による致死率を雌マウスにおいて増大させる2011

    • Author(s)
      朝井鈴佳, 金原紀章, 多田豊廣, 今井優樹, WilliamCampbell, 岡田秀親, 岡田則子
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋市立大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 急性腹膜障害に対するC5aの関与とC5a阻害薬の有用性2011

    • Author(s)
      水野智博、水野正司、櫛田真由、野田幸裕、山田清文、今井優樹岡田秀親、岡田則子、丸山彰一、松尾清一、伊藤恭彦
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋市立大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新型 H1N1 インフルエンザの重症化における補体アナフィラトキシンの関与2010

    • Author(s)
      太田里永子, 伊藤嘉規, 鳥居ゆか, 木村宏, 岡田則子,今井優樹
    • Organizer
      第47回補体シンポジウム
    • Place of Presentation
      コラッセふくしま(福島)
    • Related Report
      2012 Final Research Report
  • [Presentation] Procarboxypeptidase R Deficiency Causes Increased Lethality in Concanavalin A -induced Hepatitis in Female Mice2010

    • Author(s)
      Asai S, Imai M, Kimbara N, Tada T, Campbell W, Okada H, Okada N
    • Organizer
      XXIII International Complement Workshop
    • Place of Presentation
      New York, NY, USA, Mol. Immunol
    • Related Report
      2012 Final Research Report
  • [Presentation] Procarboxypeptidase R Deficiency Causes Increased Lethality in Concanavalin A -induced Hepatitis in Female Mice.2010

    • Author(s)
      Asai S
    • Organizer
      XXIII International Complement Workshop
    • Place of Presentation
      New York, NY, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新型H1N1インフルエンザの重症化における補体アナフィラトキシンの関与2010

    • Author(s)
      太田里永子
    • Organizer
      第47回補体シンポジウム
    • Place of Presentation
      福島(コラッセふくしま)
    • Related Report
      2010 Annual Research Report
  • [Presentation] An inhibitory peptide of C5a anaphylatoxin rescues monkeys from lethal encotoxin shock by suppressing HMGB1 release.2010

    • Author(s)
      Okada N
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe(神戸国際会議場)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsismodel.2010

    • Author(s)
      Okada H
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe(神戸国際会議場)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Membrane complement regulators may protect against encapsular peritoneal inflammation model of zymosan peritonitis in the rat.2010

    • Author(s)
      Mizuno T
    • Organizer
      XXIII International Complement Workshop
    • Place of Presentation
      New York(米国)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interruption of a cross-talk between the complement and coagulation cascade improves early outcomes after intraportalislet transplantation2010

    • Author(s)
      Tokodai K
    • Organizer
      XXIII Int Cong of the Transplant Soc
    • Place of Presentation
      Vancover(カナダ)
    • Related Report
      2010 Annual Research Report
  • [Book] 基礎編「後期経路」,「補体への招待」2011

    • Author(s)
      今井優樹、岡田則子、大井 洋之,木下 タロウ,松下 操 編
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Final Research Report
  • [Book] 補体への招待2011

    • Author(s)
      今井優樹, 岡田則子, 他
    • Total Pages
      231
    • Publisher
      メジカルビュー社
    • Related Report
      2011 Annual Research Report
  • [Book] 補体への招待2011

    • Author(s)
      今井優樹
    • Publisher
      メジカルビュー社
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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