Pathogenesis of cancer and diabetes caused by aberrant expression of sialidase
| Project/Area Number |
22659082
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
MIYAGI Taeko 東北薬科大学, 大学院・薬学研究科, 教授 (50006110)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Ikurou 宮城県立がんセンター, 病理部, 部長 (50225918)
SIOZAKI Kazuhiro 鹿児島大学, 水産学部, 助教 (70390896)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,030,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 腫瘍 / シアリダーゼ / 癌 / 糖尿病 / 酵素 / 糖鎖 / 遺伝子 |
|---|
| Research Abstract |
Plasma membrane-associated sialidase is up-regulated in various human cancers including colon cancer. The transgenic mice develop hyperinsulinemia and subsequently insulin resistance, and also are susceptible to induction of colonic aberrant crypt foci by a carcinogen, azoxymethane. Analysis of the pathogenesis revealed that NEU3 activates Wnt signaling, which is thought to be important for cancer progression and also for beta cell growth in pancreatic islets, suggesting an influence of NEU3 on the two diseases probably via Wnt activation.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Plasma membraneassociated sialidase(NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling2012
Author(s)
Kawamura, S., Sato, I., Wada, T., Yamaguchi, K., Li, Y., Li, D., Zhao, X., Ueno, S., Aoki, H., Tochigi, T., Kuwahara, M. Kitagawa, T., Takahashi, K., Moriya, S., Miyagi, T
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Journal Title
Cell Death Differ
Volume: 19
Pages: 170-179
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[Journal Article] Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides2011
Author(s)
Miyata, M., Kambe, M., Tajima, O., Moriya, S., Sawaki, H., Hotta, H., Kondo, Y., Narimatsu, H., Miyagi, T., Furukawa, K., Furukawa, K
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Journal Title
Cancer Sci
Volume: 102
Pages: 2139-2149
NAID
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[Journal Article] Regulation of plasma membrane-associated sialidase NEU3 gene by Sp1/Sp3 transcription factors2010
Author(s)
Yamaguchi, K., Koseki, K., Shiozaki, M., Shimada, Y., Wada, T., Miyagi, T
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Journal Title
Biochem, J
Volume: 430
Pages: 107-117
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[Presentation] Distinct functional roles between ganglioside sialidases Neu3 and Neu42011
Author(s)
Miyagi, T., Yamaguchi, K., Shiozaki, K., Takahashi, K., Wada, T., Hata, K., Moriya, S., Yamamoto, K
Organizer
The 31st Naito Conference : Glycan Expression and Regulation[II]: Metabolites, Stress Response, Microdomains, and Beyond
Place of Presentation
Sapporo, Japan
Year and Date
2011-09-14
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[Presentation] Altered expression of sialidases in human cancer2011
Author(s)
Miyagi, T., Takahashi, K., Moriya, S., Hata, K., Wada, T., Yamaguchi, K., Shiozaki, K
Organizer
IXth International Symposium(IXth ISCSM, 2011) on "Biochemical Roles of Eukaryotic Cell Surface Macromolecules"
Place of Presentation
Trivandrum, India
Year and Date
2011-01-28
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