| Project/Area Number |
22659088
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
MATSUZAWA Takeshi 大阪府立大学, 大学院・生命環境科学研究科, 助教 (80370154)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,060,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 自然免疫 / インターフェロン / マクロファージ / 細胞内寄生菌 / RNAiスクリーングニ / RNAiスクリーニング / インターフェロン-γ / インターフェロン誘導性タンパク質 / 細胞内寄生性細菌 / RNA干渉スクリーニング |
|---|
| Research Abstract |
The aim of this study was to identify the interferon-inducible proteins, which is involved in the immunity to bacterial pathogens. This study reveals that autophagy is activated by interferon-gamma via p38 MAPK(Journal of Immunology, in press). Moreove, p38 MAPK-mediated autophagy contributes to macrophage bactericidal activity.
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