| Project/Area Number |
22659093
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
EIZURU Yoshito 鹿児島大学, 医歯学総合研究科, 教授 (00041351)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
|---|
| Keywords | アフリカの伝統医薬 / 抗ATL細胞作用 / toosendanin / アポトーシス / 抗ATL細胞効果 / ウイルス / がん |
|---|
| Research Abstract |
The cytotoxic substance was found in African traditional medicine. This substance is cytotoxic for HTLV-1-infected lymphocyte(ATL cells), but not for normal lymphocytes. The selective index is more than 1000-fold. This substance is toosendanin, consisted of the mixture of two isomers, 12-acetoxyamoorastatin and 29-deacetylsendanin. Finally, this substance causes apoptosis of HTLV-1-infected lymphocytes
|
