| Project/Area Number |
22659094
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
SHIMO Yusuke 東京大学, 新領域創成科学科, 大学院生
OHSHIMA Daisuke 東京大学, 新領域創成科学科, 大学院生
SHINZAWA Miho 東京大学, 新領域創成科学, 大学院生
秋山 伸子 , 日本学術振興会特別研究員
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,030,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | 免疫寛容 / 自己免疫 / 胸腺 / インターフェロン / 炎症 / TNF / 転写因子 |
|---|
| Research Abstract |
Thymus generates T cells essential for acquired immune responses against pathogens or other foreign antigens. In the thymus, T cells tolerant to self-antigens are selected. Medullary thymic epithelial cells(mTECs) play a critical role of this selection mechanism. Thus, mTECs ectopically express a wide variety of self-antigens that are normally expressed in tissue restricted manner. mTECs present these self-antigens to developing T cells, thereby eliminating the T cells responsive to self-tissues. In this study, we found that proteins induced by virus-infection were ectopically expressed in mTECs. This finding implies the novel link between natural inflammation and self-tolerant mechanism in the thymus.
|
