Mimetic virus-infection in thymic medullary microenvironment
| Project/Area Number |
22659094
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Research Collaborator |
SHIMO Yusuke 東京大学, 新領域創成科学科, 大学院生
OHSHIMA Daisuke 東京大学, 新領域創成科学科, 大学院生
SHINZAWA Miho 東京大学, 新領域創成科学, 大学院生
秋山 伸子 , 日本学術振興会特別研究員
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,030,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 免疫寛容 / 自己免疫 / 胸腺 / インターフェロン / 炎症 / TNF / 転写因子 |
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| Research Abstract |
Thymus generates T cells essential for acquired immune responses against pathogens or other foreign antigens. In the thymus, T cells tolerant to self-antigens are selected. Medullary thymic epithelial cells(mTECs) play a critical role of this selection mechanism. Thus, mTECs ectopically express a wide variety of self-antigens that are normally expressed in tissue restricted manner. mTECs present these self-antigens to developing T cells, thereby eliminating the T cells responsive to self-tissues. In this study, we found that proteins induced by virus-infection were ectopically expressed in mTECs. This finding implies the novel link between natural inflammation and self-tolerant mechanism in the thymus.
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Report
(3 results)
Research Products
(44 results)
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[Journal Article] RANK signaling induces interferon-stimulated genes inthe fetal thymic2011
Author(s)
Ohshima D., Qin J., Konno H., Hirosawa A., Shiraishi T., Yanai H., Shimo Y., Shinzawa M., Akiyama N., Yamashita R., Nakai K., Akiyama T*(corresponding author), and
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 408
Issue: 4
Pages: 530-536
DOI
Related Report
Peer Reviewed
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[Journal Article] Okumura K., Kamradt T., Saito H., Nakae S. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage2011
Author(s)
Ohno T., Oboki K., Kajiwara N., Tanaka S., Ikeda M., Iikura M., Akiyama T., Inoue J., Matsumoto K., Sudo K., Azuma M.,
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Journal Title
Plos One
Volume: 6
Issue: 4
Pages: 18404-18404
DOI
Related Report
Peer Reviewed
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[Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NF-〓B pathway.2010
Author(s)
ando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J and Iba H.
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Journal Title
J. Biol. Chem
Volume: 285
Issue: 29
Pages: 21951-60
DOI
Related Report
Peer Reviewed
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[Journal Article] Human lactoferrin activates NF-kB through Toll-like receptor 4 (TLR4) pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling2010
Author(s)
Ando K, Hasegawa K, Shindo K, Furusawa T, Fujino T, Kikugawa K, Nakano H, Takeuchi O, Akira S, Akiyama T, Gohda J, Inoue J, Hayakawa M.
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Journal Title
FEBS J.
Volume: 277
Issue: 9
Pages: 2051-2066
DOI
Related Report
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