Studies on molecular mechanisms and therapeutic targets of bone marrow GVHD
| Project/Area Number |
22659095
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UEHA Satoshi 東京大学, 大学院・医学系研究科, 助教 (00447385)
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| Co-Investigator(Renkei-kenkyūsha) |
IMAMURA Masahiro 北海道大学, 大学院・医学系研究科, 教授 (20160062)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 免疫制御 / 移植免疫 / 造血幹細胞移植 / 幹細胞 / 移植 / GVHD / 血球分化 / 骨芽細胞 |
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| Research Abstract |
We have analyzed mouse allo-HSCT models to identify the molecular mechanisms and therapeutic targets of bone marrow GVHD and revealed that : 1) B cell suppression is independent of alloantigen expression on non-hematopoietic stromal cells, 2) allo-CD4^+T cells specifically express osteoblast inhibitory factor(OIF), 3) pre-osteoblast cell line differentiation is suppressed in the presence of allo-CD4^+T cells, 4) inhibition of OIF is not sufficient to suppress BM GVHD.
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Report
(3 results)
Research Products
(30 results)
