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Mechanism for sensing protease allergens by basophils

Research Project

Project/Area Number 22659096
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionShinshu University

Principal Investigator

TAKI Shinsuke  信州大学, 医学系研究科, 教授 (50262027)

Co-Investigator(Renkei-kenkyūsha) HIDA Shigeaki  信州大学, 医学系研究科, 准教授 (10345762)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsアレルギー / サイトカイン / 好塩基球 / Th2応答 / プロテアーゼ / 受容体 / IL-3 / IL-4 / 免疫学 / Th2
Research Abstract

Intracellular signal transduction through putative' sensor' for the allergen papain on murine basophils leading to IL-4 production was studied. IFcεRIβ-deficient basophils unable to display FcεRI on their cell surface mounted only around 50% magnitude of papain responses compared with those in wild-type basophils, indicating that FcεRI constitutes a fraction of papain sensors, while other, as yet unidentified, surface molecules could serve as papain sensors.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 7 results) Presentation (13 results) Remarks (2 results)

  • [Journal Article] IRF-2 regulates B cell proliferation and antibody production through distinct mechanisms2012

    • Author(s)
      Minamoto K, Takahara K, Adachi T, Nagaoka K, Iyoda T, Taki S, Inaba K
    • Journal Title

      Int Immunol

      Volume: (印刷中)

    • NAID

      120005302075

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential requirements for IFN regulatory factor-2 in generation of CD1d-independent T cells bearing NK cell receptors2012

    • Author(s)
      Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S.
    • Journal Title

      J. Immunol

      Volume: 188 Issue: 10 Pages: 4838-4845

    • DOI

      10.4049/jimmunol.1200210

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] IRF-2 regulates B cell proliferation and antibody production through distinct mechanisms2012

    • Author(s)
      Minamoto, ほか
    • Journal Title

      Int.Immunol.

      Volume: (印刷中)(未定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice2011

    • Author(s)
      o sh izawa K, Nakajima S, Notake S, Miyagawa S, Hida S, Taki, S
    • Journal Title

      J. Immunol

      Volume: 187 Issue: 10 Pages: 5162-5169

    • DOI

      10.4049/jimmunol.1101561

    • NAID

      120007108237

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia.2011

    • Author(s)
      Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U
    • Journal Title

      Cardiovasc Res

      Volume: 90 Issue: 2 Pages: 362-372

    • DOI

      10.1093/cvr/cvq397

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 活性化T細胞におけるNKレセプターの発現2011

    • Author(s)
      野竹剛、瀧伸介
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 55 Pages: 475-482

    • NAID

      40018833143

    • Related Report
      2011 Final Research Report
  • [Journal Article] Potentiation of TLR9 responses for human naive B-cell growth through RP105 signaling2010

    • Author(s)
      Yamazaki K, Yamazaki T, Taki S, Miyake K, Hayashi T, Ochs HD, Agematsu K
    • Journal Title

      J. Clin. Immunol.

      Volume: 135 Issue: 1 Pages: 125-136

    • DOI

      10.1016/j.clim.2009.12.013

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 好塩基球におけるIL-4産生誘導シグナル伝達機構とTh2分化2010

    • Author(s)
      小田朗永、瀧伸介
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 546-553

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Th2分化と好塩基球2010

    • Author(s)
      肥田重明、瀧伸介
    • Journal Title

      実験医学

      Volume: 28 Pages: 1879-1884

    • Related Report
      2011 Final Research Report
  • [Journal Article] 好塩基球からのIL-4産生誘導機序2010

    • Author(s)
      肥田重明、瀧伸介
    • Journal Title

      炎症と免疫

      Volume: 18 Pages: 9-13

    • Related Report
      2011 Final Research Report
  • [Journal Article] Potentiation of TLR9 responses for human naive B-cell growth through RP105 signaling2010

    • Author(s)
      Yamazaki, K., ほか
    • Journal Title

      Clini Immunol.

      Volume: 135 Pages: 125-136

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 好塩基球におけるサイトカイン・シグナルの正と負の制御2012

    • Author(s)
      瀧伸介
    • Organizer
      第117回日本解剖学会総会,リンパ系・免疫系懇話会
    • Place of Presentation
      甲府
    • Year and Date
      2012-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-3-induced IL-13 production by basophils but not mast cells was sensitive to Paired immunoglobulin-like receptor (PIR)-B mediated inhibitory signals2011

    • Author(s)
      Akihisa Oda, ほか
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-3-induced IL-13 production by basophils but not mast cells was sensitive to Paired immunoglobulin-like receptor(PIR)-B mediated inhibitory signals2011

    • Author(s)
      A. Oda, Y. Sakamoto, H. Sanjo, T. Notake, T. Takai, S. Hida, S. Taki
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-15-independent generation of memory-like' innate' CD8+ T cells in IRF-2-deficient mice2011

    • Author(s)
      T. Notake, A. Oda, H. Sanjo, S. Hida, S. Taki
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-15-independent generation of memory-like 'innate' CD8+ T cells in IRF-2-deficient mice2011

    • Author(s)
      Tsuyoshi Notake, ほか
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Paired immunoglobulin-like receptor(PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent manner in murine basophils2010

    • Author(s)
      A. Oda, Y. Sakamoto, T. Takai, S. Hida, S. Taki
    • Organizer
      14th international congress of immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Generation of CD1d-independent T cells bearing various NK receptors requires interferon regulatory factor-2 differentially2010

    • Author(s)
      T. Notake, S. Horisawa, F. Arakura, S. Hida, S. Taki
    • Organizer
      14th international congress of immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Generation of CDld-independlent T cells bearing various NK receptors requires interferon regulatory factor-2 differentially2010

    • Author(s)
      野竹剛, ほか
    • Organizer
      14th Internatiollal Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulation of B cell function and development through IRF-2 in type I interferon receptor-dependent and-independent mechanisms2010

    • Author(s)
      K. Minamino, T. Adachi, K. Nagaoka, K. Takahara, S. Taki, K. Inaba
    • Organizer
      14th international congress of immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Paired immunoglobulin-like receptor(PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent manner in murine basophils2010

    • Author(s)
      小田朗永, ほか
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Basophils sense various external signals with their FcRγ-associated cell surface molecule(s) to produce IL-4 in eliciting Th2 responses2010

    • Author(s)
      S. Hida, A. Oda, I. Koshi, S. Taki
    • Organizer
      14th international congress of immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Potentiation of TLR9 responses for human naive B-cell growth through RP105 signaling2010

    • Author(s)
      K. Yamazaki, T Hayashi, S. Taki, K. Miyake, H. D. Ochs, K. Agematsu
    • Organizer
      14th international congress of immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Basophils sense various external signals with their FcRγ-associated cell surface molecule(s) to produce IL-4 in eliciting Th2 responses2010

    • Author(s)
      肥田重明, ほか
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/zouki/immunol/main_frame.htm

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.shinshu_u.ac.jp/faculty/medicine/department/doctor/zouki/immunol/main_fame.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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