| Project/Area Number |
22659096
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
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| Research Institution | Shinshu University |
|---|
Principal Investigator |
TAKI Shinsuke 信州大学, 医学系研究科, 教授 (50262027)
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| Co-Investigator(Renkei-kenkyūsha) |
HIDA Shigeaki 信州大学, 医学系研究科, 准教授 (10345762)
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | アレルギー / サイトカイン / 好塩基球 / Th2応答 / プロテアーゼ / 受容体 / IL-3 / IL-4 / 免疫学 / Th2 |
|---|
| Research Abstract |
Intracellular signal transduction through putative' sensor' for the allergen papain on murine basophils leading to IL-4 production was studied. IFcεRIβ-deficient basophils unable to display FcεRI on their cell surface mounted only around 50% magnitude of papain responses compared with those in wild-type basophils, indicating that FcεRI constitutes a fraction of papain sensors, while other, as yet unidentified, surface molecules could serve as papain sensors.
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