Mechanism for sensing protease allergens by basophils
Project/Area Number |
22659096
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Immunology
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Research Institution | Shinshu University |
Principal Investigator |
TAKI Shinsuke 信州大学, 医学系研究科, 教授 (50262027)
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Co-Investigator(Renkei-kenkyūsha) |
HIDA Shigeaki 信州大学, 医学系研究科, 准教授 (10345762)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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Keywords | アレルギー / サイトカイン / 好塩基球 / Th2応答 / プロテアーゼ / 受容体 / IL-3 / IL-4 / 免疫学 / Th2 |
Research Abstract |
Intracellular signal transduction through putative' sensor' for the allergen papain on murine basophils leading to IL-4 production was studied. IFcεRIβ-deficient basophils unable to display FcεRI on their cell surface mounted only around 50% magnitude of papain responses compared with those in wild-type basophils, indicating that FcεRI constitutes a fraction of papain sensors, while other, as yet unidentified, surface molecules could serve as papain sensors.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia.2011
Author(s)
Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U
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Journal Title
Cardiovasc Res
Volume: 90
Issue: 2
Pages: 362-372
DOI
Related Report
Peer Reviewed
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