| Project/Area Number |
22659123
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
NASU Tamie 名古屋大学, 大学院・医学系研究科, 教授 (10020794)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,060,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | インターフェロンγ / 肝臓 / γGTP / 好酸球 / CYP2E1 / トリクロロエチレン / トリクロロエタノール / トリクロロ酢酸 / 皮膚 / HSP70 / GRP78 / Th1 / モルモット |
|---|
| Research Abstract |
We investigated skin and liver damages associated with trichloroethylene-, trichloroethanol-and trichloroacetic acid-induved hypersensitive skin reactions in the hartley guinea pig maximization test. The sensitization rates of trichloroethylene-induced dermal allergy were 70% in male guinea pigs, and 90% in female ones. Those of trichloroethanol were 20% in male guinea and 50% in female ones, while only a minor sensitization was seen after trichloroacetic acid treatment. In relation to the sensitization, eosinocytes were seen in the skin, and infiltration of lymphocytes was seen around focal necrosis in the liver. These changes were seen most prominent in trichloroethylene-exposed animals, followed by trichloroethanol. Trichloroethylene exposure also increased plasmaγGTP and interferonγlevels, while trichloroethanol and trichloroacetic acid did not.
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