| Project/Area Number |
22659135
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Public health/Health science
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| Research Institution | 財団法人大阪府保健医療財団 大阪がん循環器病予防センター (2012)
Osaka Medical Center for Health Science and Promotion (2010-2011) |
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Principal Investigator |
KITAMURA Akihiko 財団法人大阪府保健医療財団 大阪がん循環器病予防センター, 健康開発部, 部長 (80450922)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Ryo (財)大阪府保健医療財団大阪がん循環器病予防センター, 健康開発部, 特別研究員 (70301067)
YAMAGISHI Kazumasa 国立大学法人筑波大学, 大学院・人間総合科学研究科, 講師 (20375504)
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| Research Collaborator |
MURAKI Isao (財)大阪府保健医療財団大阪がん循環器病予防センター, Department of Nutrition, 健康開発部, Harvard School of Public Health, 特別研究員, 客員研究員
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,180,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | 健康診断 / 眼底検査 / 脳卒中予防 / 穿通枝系梗塞 / 網膜血管径 / コホート内症例対照研究 |
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| Research Abstract |
Using a quantitative retinal image analysis, we measured the diameter of retinal artery and vein in individuals participated in health screening program in Osaka, Akita, and Ibaraki. Then, we examined the association of these quantitative measures in relation to risk of developing stroke. Retinal arteriolar narrowing was associated with increased risk of stroke; compared with individuals with larger retinal arteriolar diameter, those with smaller retinal arteriolar diameter had 4 to 5-fold higher risk of stroke. This association was partially independent of traditional Scheie’s classification of retinal arteriolosclerosis. The current findings suggest that the predictive ability of the fundus assessment in relation to stroke risk may be improved by using the proposed quantitative retinal vessels in addition to the Scheie’s classification, which is widely used at health checkup in Japan.
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