| Project/Area Number |
22659137
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
KIMURA Akihiko 和歌山県立医科大学, 医学部, 准教授 (60136611)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Toshikazu 和歌山県立医科大学, 医学部, 教授 (70251923)
ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077)
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| Co-Investigator(Renkei-kenkyūsha) |
NOSAKA Mizuho 和歌山県立医科大学, 医学部, 助教 (00244731)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,760,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 体内時計 / 法医診断 / 時計遺伝子 / Real-time PCR / 心肥大 / 心不全 / 腎炎 / 皮膚損傷 / 法医病理診断 |
|---|
| Research Abstract |
Biological clock exists in most tissues and is involved in their homeostasis. Malfunction of biological clock can cause various diseases. In this study, we examined the possibility that forensic diagnosis can be performed by analysis of biological clock in the tissues. We found that significant reduction of clock gene expression in the hypertrophic heart, kidney damaged with a toxic compound and injured skin tissue, suggesting that biological clock in the damaged tissues might be a novel diagnostic marker in forensic medicine.
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