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Do gut microbiota affect body weight gain in patients with anorexia nervosa?

Research Project

Project/Area Number 22659144
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionKyushu University

Principal Investigator

SUDO Nobuyuki  九州大学, 医学研究院, 教授 (60304812)

Co-Investigator(Kenkyū-buntansha) KOGA Yasuhiro  東海大学, 医学部, 教授 (60170221)
YOSHIHARA Kazufumi  自然科学研究機構, 生理学研究所, 研究員 (20444854)
Co-Investigator(Renkei-kenkyūsha) ASANO Yasunari  九州大学, 医学研究院, 大学院生 (30572945)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,140,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsストレス / 環境 / 腸内細菌
Research Abstract

The number of patients with anorexia nervosa(AN) is rapidly increasing in industrialized countries, although enteric factors linked to AN pathophysiology are largely unknown. Especially, whether gut bacteria residing in the gut are related to the development and exacerbation of AN remains to be clarified. Our research purpose is to clarify the relationship between gut microbiota and weight gain in AN patients and healthy volunteers, using automated analytical system of gut microbiota,“YIF-scan". This study was already approved by ethical committee of our university in 2011. To date, five AN patients who are eligible and have no exclusion criteria have been enrolled in this study, and their fecal samples are being processed to YIF-scan. Interim analysis on microbiota profile will be carried out when 10 samples of patients are collected.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (31 results)

All 2012 2011 2010 Other

All Journal Article (22 results) (of which Peer Reviewed: 18 results) Presentation (8 results) Book (1 results)

  • [Journal Article] The effect of probiotics on gastric mucosal permeability in humans administered with aspirin2012

    • Author(s)
      Akama F, Nishino R, Makino S, Kobayashi K, Kamikaseda K, Nagano J, Koga Y.
    • Journal Title

      Scand J Gastroenterol

      Volume: 46 Pages: 831-836

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Global catastrophizing vs catastrophizing subdomains : assessment and associations with patient functioning2012

    • Author(s)
      Iwaki R, Arimura T, Jensen MP, Nakamura T, Yamashiro K, Makino S, Obata T, Sudo N, Kubo C, Hosoi M.
    • Journal Title

      Pain Med

      Volume: 13 Pages: 677-87

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pain questionnaire development focusing on cross-cultural equivalence to the original questionnaire : The Japanese Version of the Short-Form McGill Pain Questionnaire2012

    • Author(s)
      Arimura T, Sudo N, et al.
    • Journal Title

      Pain Med

      Volume: 13 Pages: 541-51

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pain questionnaire development focusing on cross-cultural equivalence to original questionnaire : the Japanese version of the Short-Form McGill Pain Questionnaire2012

    • Author(s)
      Arimura T, Hosoi M, Tsukiyama Y, Yoshida T, Fujiwara D, Tanaka M, Tamura R, Nakashima Y, Sudo N, Kubo C
    • Journal Title

      Pain Medicine

      Volume: 13-4(Epub ahead of print) Issue: 4 Pages: 541-551

    • DOI

      10.1111/j.1526-4637.2012.01333.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between the age of onset of type 1 diabetes and the subsequent development of a severe eating disorder by female patients2011

    • Author(s)
      Takii M, Uchigata Y, Kishimoto J, Morita C, Hata T, Nozaki T, Kawai K, Iwamoto Y, Sudo N, Kubo C.
    • Journal Title

      Pediatr Diabetes

      Volume: 12 Pages: 396-401

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Profile of mood states and stress-related biochemical indices in long-term yoga practitioners2011

    • Author(s)
      Yoshihara K, Hiramoto T, Sudo N, Kubo C.
    • Journal Title

      Biopsychosoc Med

      Volume: 5 Pages: 6-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region2011

    • Author(s)
      Lkhagvasuren B, Sudo N, et al.
    • Journal Title

      Eur J Neurosci

      Volume: 34 Pages: 1442-52

    • NAID

      120005627632

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The longitudinal BMI pattern and body composition of patients with anorexia nervosa who require urgent hospitalization : A case control study2011

    • Author(s)
      Kawai K, Sudo N, et al.
    • Journal Title

      Biopsychosoc Med

      Volume: 5 Pages: 14-14

    • NAID

      120005133142

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腸内細菌叢が精神発達・精神健康に及ぼす影響2011

    • Author(s)
      須藤信行
    • Journal Title

      医学のあゆみ

      Volume: 237 Pages: 846-847

    • Related Report
      2011 Final Research Report
  • [Journal Article] 腸内環境で変わるストレス反応性2011

    • Author(s)
      須藤信行
    • Journal Title

      心身医学

      Volume: 51 Pages: 39-44

    • Related Report
      2011 Final Research Report
  • [Journal Article] Role of indigenous lactobacilli in gastrin-mediated Acid production in the mouse stomach2011

    • Author(s)
      Takahashi H, Nakano Y, Matsuoka T, Kumaki N, Asami Y, Koga Y.
    • Journal Title

      Appl Environ Microbiol

      Volume: 77 Pages: 6964-6971

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The longitudinal BMI pattern and body composition of patients with anorexia nervosa who require urgent hospitalization : A case control study2011

    • Author(s)
      Kawai K, Sudo N, et al
    • Journal Title

      Biopsychosoc Med

      Volume: 5 Issue: 1 Pages: 14-14

    • DOI

      10.1186/1751-0759-5-14

    • NAID

      120005133142

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictors of menstrual resumption by patients with anorexia nervosa2010

    • Author(s)
      Arimura C, Nozaki T, Takakura S, Kawai K, Takii M, Sudo N, Kubo C.
    • Journal Title

      Eat Weight Disord

      Volume: 15 Pages: 226-33

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The parenting attitudes and the stress of mothers predict the asthmatic severity of their children : a prospective study2010

    • Author(s)
      Nagano J, Kakuta C, Motomura C, Odajima H, Sudo N, Nishima S, Kubo C.
    • Journal Title

      Biopsychosoc Med

      Volume: 4 Pages: 12-12

    • NAID

      120005227373

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒト-細菌共生系の驚き2010

    • Author(s)
      須藤信行
    • Journal Title

      科学

      Volume: 81 Pages: 243-243

    • Related Report
      2011 Final Research Report
  • [Journal Article] ストレスと神経・内分泌・免疫2010

    • Author(s)
      須藤信行
    • Journal Title

      綜合臨牀

      Volume: 59 Pages: 2198-2201

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mood and gut feelings2010

    • Author(s)
      Forsythe P, Sudo N, Dinan T, et al.
    • Journal Title

      Brain Behav Immum

      Volume: 24 Pages: 9-16

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of the properties of bifidobacterial isolates from fecal samples of mother-infant pairs2010

    • Author(s)
      Takahashi H, Mikami K, Nishino R, Matsuoka T, Kimura M, Koga Y.
    • Journal Title

      J Pediatr Gastroenterol Nutr

      Volume: 51 Pages: 653-60

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The parenting attitudes and the stress of mothers predict the asthmatic severity of their children : a prospective study.2010

    • Author(s)
      Nagano J, Kakuta C, Motomura C, Odajima H, Sudo N, Nishima S, Kubo C.
    • Journal Title

      Biopsychosocial Medicine

      Volume: 4

    • NAID

      120005227373

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictors of menstrual resumption by patients with anorexia nervosa2010

    • Author(s)
      Arimura C, Nozaki T, Takakura S, Kawai K, Takii M, Sudo N, Kubo C.
    • Journal Title

      Eating and Weight Disorders

      Volume: 15(4)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The outcome of Japanese anorexia nervosa patients treated with an inpatient therapy in an internal medicine unit

    • Author(s)
      Amemiya N, Takii M, Hata T, Morita C, Takakura S, Oshikiri K, Urabe H, Tokunaga S, Nozaki T, Kawai K, Sudo N, Kubo C.
    • Journal Title

      Eat Weight Disord

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between the age of onset of type 1 diabetes and the subsequent development of a severe eating disorder by female patients.

    • Author(s)
      Takii M, Uchigata Y, Kishimoto J, Morita C, Hata T, Nozaki T, Kawai K, Iwamoto Y, Sudo N, Kubo C.
    • Journal Title

      Pediatric Diabetes

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 心とアレルギー2011

    • Author(s)
      須藤信行
    • Organizer
      小児アレルギー学会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 心とアレルギー2011

    • Author(s)
      須藤信行
    • Organizer
      小児アレルギー学会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心理社会的因子とアレルギー2010

    • Author(s)
      須藤信行
    • Organizer
      第60回日本アレルギー学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2010-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Possible role of gut microbiota in infant mental development2010

    • Author(s)
      Sudo N.
    • Organizer
      19th International Symposium on Intestinal Flora
    • Place of Presentation
      Tokyo.
    • Year and Date
      2010-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 腸内細菌研究の動向と心身医学との接点2010

    • Author(s)
      須藤信行
    • Organizer
      第12回日本神経消化器病学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Gut microbiota influence the hypothalamic-pituitary-adrenal response to stress in mice2010

    • Author(s)
      Sudo N.
    • Organizer
      Asian Congress on Psychosomatic Medicine
    • Place of Presentation
      Beijing
    • Year and Date
      2010-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 腸内環境で変わるストレス反応性-腸内フローラとストレス-2010

    • Author(s)
      須藤信行
    • Organizer
      日本心身医学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳腸相関から見たプロバイオティクスの展望2010

    • Author(s)
      須藤信行
    • Organizer
      プロバイオティクス学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-16
    • Related Report
      2011 Final Research Report
  • [Book] 「心身症」,今日の治療指針2011

    • Author(s)
      須藤信行
    • Total Pages
      873
    • Publisher
      医学書院,東京
    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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