Generation of a mouse model that shows specific features of human diseases.

• Project/Area Number: 22659147
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Hiroshima University
• Principal Investigator: CHAYAMA Kazuaki 広島大学, 大学院・医歯薬学総合研究科, 教授 (00211376)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,240,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: 肝臓学 / ノックアウトマウス / トランスジェニックマウス / 不死化肝細胞 / uPA scid mouse

Research Abstract

Small animal model such as knockout mouse is a valuable tool to study human diseases. We infected human hepatocyte chimeric mice with hepatitis B virus and administered human peripheral white blood cells. The mice developed fulminant hepatitis like massive human liver cell necrosis. The mouse hepatocyte death has been found to be mediated with FAS-FASL system via NK cell response mediated by dendritic cells. This model will be useful to develop treatment against fulminant hepatitis B.

Research Products

• [Journal Article] Severe necroinflammatory reaction caused by natural killer by Fas/ FasL interaction and dendritic cells in human hepatocyte chimeric mouse (2012)
  • Author(s): Okazaki A, Hiraga N, Imamura M, NelsonHayes C, Tsuge M, Takahashi S, AikataH, Abe H, Miki D, Ochi H, Tateno C, Yoshizato K, Ohdan H, Chayama K
  • Journal Title: Hepatology Volume: (in press) Issue: 2 Pages: 25651-25651
  • DOI: 10.1002/hep.25651
  • Peer Reviewed
• [Journal Article] Toward the establishment of a prediction system for thepersonalized treatment of chronic hepatitis C (2012)
  • Author(s): Ochi H, Hayes CN, Abe H, Hayashida Y, Uchiyama T, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Infect Dis Volume: 205 Issue: 2 Pages: 204-210
  • DOI: 10.1093/infdis/jir726
  • Peer Reviewed
• [Journal Article] Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 inJapan (2012)
  • Author(s): Kumada H, Toyota J, Okanoue T, ChayamaK, Tsubouchi H, Hayashi N
  • Journal Title: J Hepatol Volume: 56 Issue: 1 Pages: 78-84
  • DOI: 10.1016/j.jhep.2011.07.016
  • Peer Reviewed
• [Journal Article] Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, inhepatitis C virus genotype1b-infected null responders (2012)
  • Author(s): Chayama K, Takahashi S, Toyota J, Karino Y, Ikeda K, Ishikawa H, Watanabe H, McPhee F, Hughes E, KumadaH
  • Journal Title: Hepatology Volume: 55 Issue: 3 Pages: 742-748
  • DOI: 10.1002/hep.24724
  • Peer Reviewed
• [Journal Article] Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection (2012)
  • Author(s): Tanimoto Y, Tashiro H, Aikata H, Amano H, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Takahashi S, Itamoto T, Chayama K, Ohdan H
  • Journal Title: Ann Surg Oncol Volume: 19 Issue: 2 Pages: 418-425
  • DOI: 10.1245/s10434-011-1866-1
  • Peer Reviewed
• [Journal Article] IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients (2012)
  • Author(s): Ohnishi M, Tsuge M, Kohno T, Zhang Y, Abe H, Hyogo H, Kimura Y, Miki D, Hiraga N, Imamura M, Takahashi S, Ochi H, Hayes CN, Tanaka S, Arihiro K, Chayama K
  • Journal Title: J Gastroenterol Volume: (in press) Issue: 7 Pages: 834-844
  • DOI: 10.1007/s00535-012-0550-y
  • NAID: 10030962375
  • Peer Reviewed
• [Journal Article] Serum PAI-1 is a novel predictor for response to pegylated interferon-al pha-2b plus ribavirin therapy in chronic hepatitis C virus infection (2012)
  • Author(s): Miki D, Ohishi W, Ochi H, Hayes CN, Abe H, Tsuge M, Imamura M, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Viral Hepat Volume: 19 Issue: 2 Pages: 126-133
  • DOI: 10.1111/j.1365-2893.2011.01516.x
  • Peer Reviewed
• [Journal Article] Hepatocellular carcinoma : towards personalized medicine (2012)
  • Author(s): Miki D, Ochi H, Nelson Hayes C, Aikata H, Chayama K
  • Journal Title: Cancer Sci Volume: (in press) Issue: 5 Pages: 846-850
  • DOI: 10.1111/j.1349-7006.2012.02242.x
  • Peer Reviewed
• [Journal Article] Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B (2012)
  • Author(s): Matsumoto A, Tanaka E, Suzuki Y, Kobayashi M, Tanaka Y, Shinkai N, Hige S, Yatsuhashi H, Nagaoka S, Chayama K, Tsuge M, Yokosuka O, Imazeki F, Nishiguchi S, Saito M, Fujiwara K, Torii N, Hiramatsu N, Karino Y, Kumada H
  • Journal Title: Hepatol Res Volume: 42 Issue: 2 Pages: 139-149
  • DOI: 10.1111/j.1872-034x.2011.00910.x
  • NAID: 10031144221
  • Peer Reviewed
• [Journal Article] Efficacy and safety of telaprevir, a new protease inhibitor, for difficult-to-treat patients with genotype 1 chronic hepatitis C (2012)
  • Author(s): Hayashi N, Okanoue T, Tsubouchi H, Toyota J, Chayama K, Kumada H
  • Journal Title: J Viral Hepat Volume: 19 Issue: 2 Pages: 134-42
  • DOI: 10.1111/j.1365-2893.2011.01528.x
  • Peer Reviewed
• [Journal Article] Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan : a multicenter large retrospective study (2012)
  • Author(s): Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T, Jsg N
  • Journal Title: J Gastroenterol Volume: (in press) Issue: 5 Pages: 586-595
  • DOI: 10.1007/s00535-012-0533-z
  • NAID: 10030650741
  • Peer Reviewed
• [Journal Article] Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population (2012)
  • Author(s): Sumida Y, Yoneda M, Hyogo H, Itoh Y, Ono M, Fujii H, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Fujita K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T, Jsg-Nafld JS
  • Journal Title: BMC Gastroenterol Volume: (Epub) Issue: 1 Pages: 2-2
  • DOI: 10.1186/1471-230x-12-2
  • NAID: 120005122663
  • Peer Reviewed
• [Journal Article] Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor (2012)
  • Author(s): Sainz B, Jr., Barretto N, Martin DN, Hiraga N, Imamura M, Hussain S, Marsh KA, Yu X, Chayama K, Alrefai WA, Uprichard SL
  • Journal Title: Nat Med Volume: 18 Issue: 2 Pages: 281-285
  • DOI: 10.1038/nm.2581
  • Peer Reviewed
• [Journal Article] Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property (2012)
  • Author(s): Hyogo H, Yamagishi SI, Maeda S, Kimura Y, Ishitobi T, Chayama K
  • Journal Title: Dig Liver Dis Volume: (in press) Issue: 6 Pages: 482-486
  • DOI: 10.1016/j.dld.2011.12.013
  • NAID: 120005308251
  • Peer Reviewed
• [Journal Article] Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variati on Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy (2012)
  • Author(s): Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H
  • Journal Title: Intervirology Volume: 55 Issue: 3 Pages: 231-41
  • DOI: 10.1159/000328327
  • Peer Reviewed
• [Journal Article] Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses (2011)
  • Author(s): Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H
  • Journal Title: Gastroenterology Volume: 141 Issue: 1 Pages: 1-5
  • DOI: 10.1053/j.gastro.2011.05.027
  • Peer Reviewed
• [Journal Article] Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice (2011)
  • Author(s): Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, Hayes CN, Chayama K
  • Journal Title: J Infect Dis Volume: 204 Issue: 2 Pages: 224-228
  • DOI: 10.1093/infdis/jir247
  • Peer Reviewed
• [Journal Article] Hepatitis C virus infectionsuppresses the interferon response inthe liver of the human hepatocytechimeric mouse (2011)
  • Author(s): Tsuge M, Fujimoto Y, Hiraga N, ZhangY, Ohnishi M, Kohno T, Abe H, Miki D, Imamura M, Takahashi S, Ochi H, HayesCN, Miya F, Tsunoda T, Chayama K
  • Journal Title: PLoS One Volume: 6 Issue: 8 Pages: 23856-23856
  • DOI: 10.1371/journal.pone.0023856
  • Peer Reviewed
• [Journal Article] Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir (2011)
  • Author(s): Suzuki F, Suzuki Y, Akuta N, Sezaki H, Hirakawa M, Kawamura Y, Hosaka T, Kobayashi M, Saito S, Arase Y, IkedaK, Kobayashi M, Chayama K, Kamatani N, Nakamura Y, Miyakawa Y, Kumada H
  • Journal Title: Hepatology Volume: 53 Issue: 2 Pages: 415-421
  • DOI: 10.1002/hep.24058
  • Peer Reviewed
• [Journal Article] In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis (2011)
  • Author(s): Saeed M, Shiina M, Date T, Akazawa D, Watanabe N, Murayama A, Suzuki T, Watanabe H, Hiraga N, Imamura M, Chayama K, Choi Y, Krawczynski K, Liang TJ, Wakita T, Kato T
  • Journal Title: Hepatology Volume: 54 Issue: 2 Pages: 425-433
  • DOI: 10.1002/hep.24399
  • Peer Reviewed
• [Journal Article] Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma (2011)
  • Author(s): Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, TsugeM, Chayama K
  • Journal Title: Hepatology Volume: 53 Issue: 4 Pages: 1237-1245
  • DOI: 10.1002/hep.24207
  • Peer Reviewed
• [Journal Article] Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice (2011)
  • Author(s): Ohara E, Hiraga N, Imamura M, Iwao E, Kamiya N, Yamada I, Kono T, Onishi M, Hirata D, Mitsui F, Kawaoka T, TsugeM, Takahashi S, Abe H, Hayes CN, OchiH, Tateno C, Yoshizato K, Tanaka S, Chayama K
  • Journal Title: JHepatol Volume: 54 Issue: 5 Pages: 872-878
  • DOI: 10.1016/j.jhep.2010.08.033
  • Peer Reviewed
• [Journal Article] IL-28B predicts response to chronic hepatitis Ctherapy-fine-mapping and replication study in Asian populations (2011)
  • Author(s): Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Imamura M, Hiraga N, Kawakami Y, Aimitsu S, Kao JH, Kubo M, Tsunoda T, Kumada H, Nakamura Y, HayesCN, Chayama K
  • Journal Title: J Gen Virol Volume: 92 Issue: 5 Pages: 1071-1081
  • DOI: 10.1099/vir.0.029124-0
  • Peer Reviewed
• [Journal Article] Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers (2011)
  • Author(s): Miki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, KumadaH, Toyota J, Morizono T, Tsunoda T, Kubo M, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: Nat Genet Volume: 43 Issue: 8 Pages: 797-800
  • DOI: 10.1038/ng.876
  • Peer Reviewed
• [Journal Article] A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population (2011)
  • Author(s): Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, Takahashi A, Kamatani Y, Miki D, Abe H, Tsunoda T, Kamatani N, Chayama K, Nakamura Y, Matsuda K
  • Journal Title: Hum Mol Genet Volume: 20 Issue: 19 Pages: 3884-3892
  • DOI: 10.1093/hmg/ddr301
  • Peer Reviewed
• [Journal Article] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b (2011)
  • Author(s): Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, KuboM, Tsunoda T, Nakamura Y, Kumada H, Chayama K
  • Journal Title: J Hepatol Volume: 54 Issue: 3 Pages: 408-414
  • DOI: 10.1016/j.jhep.2010.07.032
  • Peer Reviewed
• [Journal Article] Rapidemergence of telaprevir resistanthepatitis C virus strain from wildtypeclone in vivo (2011)
  • Author(s): Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, TakahashiS, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, KanaiA, Inaba T, Tanaka S, Chayama K
  • Journal Title: Hepatology Volume: 54 Issue: 3 Pages: 781-788
  • DOI: 10.1002/hep.24460
  • Peer Reviewed
• [Journal Article] Impact of viral aminoacid substitutions and hostinterleukin-28b polymorphism on replication and susceptibility tointerferon of hepatitis C virus (2011)
  • Author(s): Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, TatenoC, Yoshizato K, Nakamura Y, KamataniN, Chayama K
  • Journal Title: Hepatology Volume: 54 Issue: 3 Pages: 764-711
  • DOI: 10.1002/hep.24453
  • Peer Reviewed
• [Journal Article] HCV substitutions and IL28B polymorphisms on outcome ofpeg-interferon plus ribavirincombination therapy (2011)
  • Author(s): Hayes CN, Kobayashi M, Akuta N, SuzukiF, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: Gut Volume: 60 Issue: 2 Pages: 261-267
  • DOI: 10.1136/gut.2010.223495
  • Peer Reviewed
• [Journal Article] A single nucleotidepoly morphism in activated Cdc42 associated tyrosine kinase 1influences the interferon therapy in hepatitis C patients (2011)
  • Author(s): Fujimoto Y, Ochi H, Maekawa T, Abe H, Hayes CN, Kumada H, Nakamura Y, Chayama K
  • Journal Title: J Hepatol Volume: 54 Issue: 4 Pages: 629-639
  • DOI: 10.1016/j.jhep.2010.07.021
  • Peer Reviewed
• [Journal Article] IL28B butnot ITPA polymorphism is predictive ofresponse to pegylated interferon, ribavirin, and telaprevir tripletherapy in patients with genotype 1hepatitis C (2011)
  • Author(s): Chayama K, Hayes CN, Abe H, Miki D, Ochi H, Karino Y, Toyota J, NakamuraY, Kamatani N, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H
  • Journal Title: J Infect Dis Volume: 204 Issue: 1 Pages: 84-93
  • DOI: 10.1093/infdis/jir210
  • Peer Reviewed
• [Journal Article] ME3738 enhances the effect of interferon andinhibits hepatitis C virusreplication both in vitro and in vivo (2011)
  • Author(s): Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, OchiH, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K, Chayama K
  • Journal Title: J Hepatol Volume: 55 Issue: 1 Pages: 11-18
  • DOI: 10.1016/j.jhep.2010.10.017
  • Peer Reviewed
• [Journal Article] IL28 variationaffects expression of interferonstimulated genes and peg-interferonand ribavirin the rapy (2011)
  • Author(s): Abe H, Hayes CN, Ochi H, Maekawa T, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Chayama K
  • Journal Title: J Hepatol Volume: 54 Issue: 6 Pages: 1094-1101
  • DOI: 10.1016/j.jhep.2010.09.019
  • Peer Reviewed
• [Journal Article] A randomized phase II trial of intra-arterial chemotherapy using SM-11355 (Miriplatin) for hepatocellular carcinoma (2011)
  • Author(s): Okusaka T, Kasugai H, Ishii H, Kudo M, Sata M, Tanaka K, Shioyama Y, Chayama K, Kumada H, Yoshikawa M, Seki T, Saito H, Hayashi N, Shiratori K, Okita K, Sakaida I, Honda M, Kusumoto Y, Tsutsumi T, Sakata K
  • Journal Title: Invest New Drugs (Epub 21 Dec.) Volume: (E-pub) Issue: 5 Pages: 2015-2025
  • DOI: 10.1007/s10637-011-9776-4
  • Peer Reviewed
• [Journal Article] Treatment of chronic hepatitis B with nuoleos(t)ide analogues (2011)
  • Author(s): Ohishi W, Chayama K
  • Journal Title: Hepatol Ees Volume: 42 Issue: 3 Pages: 219-25
  • DOI: 10.1111/j.1872-034x.2011.00921.x
  • Peer Reviewed
• [Journal Article] Recent trend of clinical features in patients with hepatocellular carcinoma (2011)
  • Author(s): Nagaoki Y, Hyogo H, Aikata H, Tanaka M, Naeshiro N, Nakahara T, Honda Y, Miyaki D, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Chayama K
  • Journal Title: Hepatol Res (Epub 13 Dec.) Volume: (Epub) Issue: 4 Pages: 368-375
  • DOI: 10.1111/j.1872-034x.2011.00929.x
  • NAID: 10031144249
  • Peer Reviewed
• [Journal Article] Platelet count for predicting fibrosis in nonalcoholic fatty liver disease (2011)
  • Author(s): Yoneda M, Fujii H, Sumida Y, Hyogo H, Itoh Y, Ono M, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Imajo K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T, Japan Study Group of Nonal coholic Fatty Liver D
  • Journal Title: J Gastroenterol Volume: 46 Issue: 11 Pages: 1300-1306
  • DOI: 10.1007/s00535-011-0436-4
  • NAID: 10030294888
  • Peer Reviewed
• [Journal Article] Clinical outcome of esophageal varices after hepatic arterial infusion chemotlierapy for advanced hepatocellular carcinoma with major portal vein tumor thrombus (2011)
  • Author(s): Kodama H, Aikata H, Murakami E, Miyaki D, Nagaoki Y, Hashimoto Y, Azakami T, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Ishikawa M, Kakizawa H, Awai K, Kenio M, Nagata Y, Chayama K
  • Journal Title: Hepatol Res Volume: 41 Issue: 11 Pages: 1046-1056
  • DOI: 10.1111/j.1872-034x.2011.00857.x
  • Peer Reviewed
• [Journal Article] Eradication of hepatitis C virus genotype 1 after liver transplantation by interferon therapy before surgery : Report of three patients with analysis of interleukin-28 polymorphism, hepatitis C virus core region and interferon-sensitivity determining region (2011)
  • Author(s): Kawaoka T, Aikata H, Miyaki D, Murakami E, Azakami T, Takaki S, Nagaoki Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Hiraga N, Miki D, TsugeM, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H, Chayama K
  • Journal Title: Hepatol Res Volume: 41 Issue: 11 Pages: 1126-1131
  • DOI: 10.1111/j.1872-034x.2011.00853.x
  • NAID: 10031144190
  • Peer Reviewed
• [Journal Article] A huge metastatic liver tumor from leiomyosarcoma of the inferior vena cava : report of a case (2011)
  • Author(s): Hashimoto M, Kobayashi T, Tashiro H, Amano H, Oshita A, Tanimoto Y, Kuroda S, Tazawa H, Aikata H, Chayama K, Fujii M, Arihiro K, Ohdan H
  • Journal Title: Surg Today (Epub 30 Nov.) Volume: (Epub) Issue: 5 Pages: 505-508
  • DOI: 10.1007/s00595-011-0070-z
  • NAID: 10030621850
  • Peer Reviewed
• [Journal Article] Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis (2011)
  • Author(s): Yoshida K, Ohishi W, Nakashima E, Fujiwara S, Akahoshi M, Kasagi F, Chayama K, Hakoda M, Kyoizumi S, Nakachi K, Hayashi T, Kusunoki Y
  • Journal Title: Hum Immunol Volume: 72 Issue: 10 Pages: 821-826
  • DOI: 10.1016/j.humimm.2011.05.029
  • NAID: 120006547414
  • Peer Reviewed
• [Journal Article] Prevention of hepatitis B virus reactivation in immunosuppressive therapy or chemotherapy (2011)
  • Author(s): Ohishi W, Chayama K
  • Journal Title: Clin Exp Nephrol Volume: 15 Issue: 5 Pages: 634-640
  • DOI: 10.1007/s10157-011-0464-7
  • NAID: 10030340714
  • Peer Reviewed
• [Journal Article] IL28B polymorphism may guide pegylated interferon plus ribavirin therapy even after curative treatment for hepatitis C virus-related hepatooellular carcinoma (2011)
  • Author(s): Kawaoka T, Aikata H, Takaki S, Hiramatsu A, Waki K, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H, Chayama K
  • Journal Title: J Viral Hepat Volume: 18 Issue: 10 Pages: e550-e560
  • DOI: 10.1111/j.1365-2893.2011.01468.x
  • Peer Reviewed
• [Journal Article] Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state (2011)
  • Author(s): Abe H, Hayes CN, Ochi H, Tsuge M, Miki D, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: J Med Virol Volume: 83 Issue: 9 Pages: 1597-1607
  • DOI: 10.1002/jmv.22158
  • Peer Reviewed
• [Journal Article] Achievement of Sustained Viral Response after Switching Treatment from Pegylated Interferon alpha-2b to alpha-2a and Ribavirin in Patients with Recurrence of Hepatitis C Virus Genotype 1 Infection after Liver Transplantation : A Case Report (2011)
  • Author(s): Kawaoka T, Hiraga N, Takahashi S, Takaki S, Tsuge M, Nagaoki Y, Hashimoto Y, Katamura Y, Muki D, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Ochi H, Tashiro H, Ohdan H, Chayama K
  • Journal Title: Intervirology (Elpub 25 Aug.) Volume: (Epub) Issue: 4 Pages: 306-310
  • DOI: 10.1159/000328661
  • Peer Reviewed
• [Journal Article] Treatment strategy for early hepatocellular carcinomas : comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection (2011)
  • Author(s): Tashiro H, Aikata H, Waki K, Amano H, Oshita A, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Chayama K, Asahara T, Ohdan H
  • Journal Title: J Surg Oncol Volume: 104 Issue: 1 Pages: 3-9
  • DOI: 10.1002/jso.21745
  • Peer Reviewed
• [Journal Article] Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients (2011)
  • Author(s): Ozeki I, Akaike J, Karino Y, Arakawa T, Kuwata Y, Ohmura T, Sato T, Kamiya N, Yamada I, Chayama K, Kumada H, Toyota J
  • Journal Title: J Gastroenterol Volume: 46 Issue: 7 Pages: 929-937
  • DOI: 10.1007/s00535-011-0411-0
  • NAID: 10029313367
  • Peer Reviewed
• [Journal Article] Impact of ribavirin dose reduction on the efficacy of pegylated interferon plus ribavirin combination therapy for elderly patients infected with genotype 1b and high viral loads (2011)
  • Author(s): Kohno H, Kouno H, Aimitsu S, Aisaka Y, Kitamoto M, Kawakami H, Chayama K
  • Journal Title: Hepatol Ees Volume: 41 Issue: 7 Pages: 626-634
  • DOI: 10.1111/j.1872-034x.2011.00811.x
  • Peer Reviewed
• [Journal Article] Clinical features and prognosis in patients with hepatocellular carcinom a that developed after hepatitis C virus eradication with interferon therapy (2011)
  • Author(s): Nagaoki Y, Aikata H, Miyaki D, Murakami E, Hashimoto Y, Katamura Y, Azakami T, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Chayama K
  • Journal Title: J Gastroenterol Volume: 46 Issue: 6 Pages: 799-808
  • DOI: 10.1007/s00535-011-0384-z
  • Peer Reviewed
• [Journal Article] Significant regression of a cavernous hepatic hemangioma to a sclerosed hemangioma over 12 years : a case study (2011)
  • Author(s): Mlyaki D, Aikata H, Waki K, Murakami E, Hashimoto Y, Nagaoki Y, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Imamura M, Takahashi S, Ohya T, Sakimoto H, Arihiro K, Chayama K
  • Journal Title: Nihon Shokakibyo Gakkai Zasshi Volume: 108 Pages: 954-961
  • NAID: 10031122114
  • Peer Reviewed
• [Journal Article] Cutaneous complications after transcatheter arterial treatment for hepat ocellular carcinoma via the internal mammary artery : how to avoid this complication (2011)
  • Author(s): Kajiwara K, Kakizawa H, Takeuchi N, Toyota N, Hieda M, Ishikawa M, Tanitame K, Tani G, Suzuki T, Fujikawa K, Aikata H, Chayama K, Awai K
  • Journal Title: Jpn J Radiol Volume: 29 Issue: 5 Pages: 307-315
  • DOI: 10.1007/s11604-011-0559-9
  • NAID: 50008099049
  • Peer Reviewed
• [Journal Article] Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b (2011)
  • Author(s): Hashimoto Y, Ochi H, Abe H, Hayashida Y, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Nelson Hayes C, Ohishi W, Kubo M, Tsunoda T, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Med Virol Volume: 83 Issue: 6 Pages: 981-988
  • DOI: 10.1002/jmv.22028
  • Peer Reviewed
• [Journal Article] Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy (2011)
  • Author(s): Azakami T, Hayes CN, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: J Med Virol Volume: 83 Issue: 6 Pages: 1048-1057
  • DOI: 10.1002/jmv.22069
  • Peer Reviewed
• [Journal Article] HCV replication animal model (2011)
  • Author(s): Imamura M, Hiraga N, Chayama K
  • Journal Title: Nihon Rinsho Volume: 69 Suppl 4 Pages: 75-79
  • NAID: 40018838443
  • Peer Reviewed
• [Journal Article] Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C (2011)
  • Author(s): Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H, Kumada H
  • Journal Title: J Gastroenterol Volume: 46 Issue: 4 Pages: 545-555
  • DOI: 10.1007/s00535-010-0358-6
  • NAID: 10029028821
  • Peer Reviewed
• [Journal Article] Long-term use ofentecavir in nucleoside-naiveJapanese patients with chronichepatitis B infection (2010)
  • Author(s): Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, Ishikawa H, Masaki N, Seriu T, Omata M
  • Journal Title: J Hepatol Volume: 52 Issue: 6 Pages: 791-799
  • DOI: 10.1016/j.jhep.2009.12.036
  • Peer Reviewed
• [Journal Article] HBx protein is indispensable for development of viraemia in human hepatocyte chimericmice (2010)
  • Author(s): Tsuge M, Hiraga N, Akiyama R, TanakaS, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, TakahashiS, Hayes CN, Chayama K
  • Journal Title: J Gen Virol Volume: 91 Issue: 7 Pages: 1854-1864
  • DOI: 10.1099/vir.0.019224-0
  • Peer Reviewed
• [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/ 2b chimeric clones (2010)
  • Author(s): Suda G, Sakamoto N, Itsui Y, NakagawaM, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
  • Journal Title: Virology Volume: 407 Issue: 1 Pages: 80-90
  • DOI: 10.1016/j.virol.2010.07.041
  • Peer Reviewed
• [Journal Article] ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy-a genome-wide study ofJapanese HCV virus patients (2010)
  • Author(s): Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, Hayes CN, Kumada H, Nakamura Y, Chayama K
  • Journal Title: Gastroenterology Volume: 139 Issue: 4 Pages: 1190-1197
  • DOI: 10.1053/j.gastro.2010.06.071
  • Peer Reviewed
• [Journal Article] Cellculture and in vivo analyses of cytopathic hepatitis C virus mutants (2010)
  • Author(s): Mishima K, Sakamoto N, Sekine-OsajimaY, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
  • Journal Title: Virology Volume: 405 Issue: 2 Pages: 361-369
  • DOI: 10.1016/j.virol.2010.06.020
  • Peer Reviewed
• [Journal Article] Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor (2010)
  • Author(s): Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K, Chayama K
  • Journal Title: J Gen Virol Volume: 91 Issue: 7 Pages: 1668-1677
  • DOI: 10.1099/vir.0.019315-0
  • Peer Reviewed
• [Journal Article] Amino acidsubstitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin (2010)
  • Author(s): Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H
  • Journal Title: Hepatology Volume: 52 Issue: 2 Pages: 421-4293
  • DOI: 10.1002/hep.23690
  • Peer Reviewed
• [Journal Article] Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients (2010)
  • Author(s): Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, ChayamaK
  • Journal Title: J Hepatol Volume: 53 Issue: 3 Pages: 439-443
  • DOI: 10.1016/j.jhep.2010.03.022
  • NAID: 120002577227
  • Peer Reviewed
• [Journal Article] Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy. (2010)
  • Author(s): Kitamura S, Tsuge M, Hatakeyama T, Abe H, Imamura M, Mori N, Saneto H, Kawaoka T, Mitsui F, Hiraga N, Takaki S, Kawakami Y, Aikata H, Takahashi S, Ohishi W, Ochi H, Hayes CN, Chayama K
  • Journal Title: Antivir Ther Volume: 15(8) Pages: 1087-1097
  • Peer Reviewed
• [Journal Article] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. (2010)
  • Author(s): Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H, Chayama K
  • Journal Title: J Hepatol Volume: 54(3) Pages: 408-414
  • Peer Reviewed
• [Journal Article] HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy. (2010)
  • Author(s): Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K.
  • Journal Title: Gut Volume: 60(2) Pages: 261-267
  • Peer Reviewed
• [Journal Article] Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C (2010)
  • Author(s): Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H, Kumada H.
  • Journal Title: Hepatol Res. Volume: 12 Pages: 1155-1167
  • NAID: 10028172403
  • Peer Reviewed
• [Journal Article] IL-6-mediated intersubgenotypic variation of interfer on sensitivity in hepatitis C virus genotype 2a/2b chimeric clones (2010)
  • Author(s): Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M.
  • Journal Title: Virology. Volume: 407(1) Pages: 80-90
  • Peer Reviewed
• [Journal Article] Prolongation of interferon therapy for recurrent hepatitis C after living donor liver transplantation : analysis of predictive factors of sustained virological response, including amino acid sequence of the core and NS5A regions of hepatitis C virus (2010)
  • Author(s): Kawaoka T, Hiraga N, Takahashi S, Takaki S, Mitsui F, Tsuge M, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Tashiro H, Ohdan H., Chayama K.
  • Journal Title: Scand J Gastroenterol Volume: 45(12) Pages: 1488-1496
  • Peer Reviewed
• [Journal Article] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin. (2010)
  • Author(s): Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H.
  • Journal Title: Hepatology Volume: 52(2) Pages: 421-429
  • Peer Reviewed
• [Journal Article] ITPA Polymorphism Affects Ribavirin-induced Anemia and Outcome of Therapy-a Genome-wide Study of Japanese HCV Patients. (2010)
  • Author(s): Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, Hayes CN, Kumada H, Nakamura Y, Chayama K
  • Journal Title: Gastroenterology. Volume: 139(4) Pages: 1190-1197
  • Peer Reviewed
• [Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants. (2010)
  • Author(s): Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
  • Journal Title: Virology. Volume: 30;405(2) Pages: 361-369
  • Peer Reviewed
• [Journal Article] common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients. (2010)
  • Author(s): Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, Chayama K.
  • Journal Title: J Hepatol. Volume: 53(3) Pages: 439-443
  • NAID: 120002577227
  • Peer Reviewed
• [Journal Article] Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B. (2010)
  • Author(s): Mitsui F, Tsuge M, Kimura T, Kitamura S, Abe H, Saneto H, Kawaoka T, Miki D, Hatakeyama T, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Hayes CN, Igarashi H, Morimoto K, Shimizu M, Chayama K.
  • Journal Title: Antimicrob Agents Chemother Volume: 54(8) Pages: 3205-3211
  • Peer Reviewed
• [Journal Article] Long-term use of entecavir in nucleoside-naive Japanese patients with chronic hepatitis B infection. (2010)
  • Author(s): Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, Ishikawa H, Masaki N, Seriu T, Omata M.
  • Journal Title: J Hepatol Volume: 52(6) Pages: 791-799
  • Peer Reviewed
• [Journal Article] Differential effects of interferon and lamivudine on serum HBV RNA inhibition in patients with chronic hepatitis B. (2010)
  • Author(s): Huang YW, Chayama K, Tsuge M, Takahashi S, Hatakeyama T, Abe H, Hu JT, Liu CJ, Lai MY, Chen DS, Yang SS, Kao JH.
  • Journal Title: Antivir Ther Volume: 15(2) Pages: 177-184
  • Peer Reviewed
• [Journal Article] HBx protein is indispensable for development of viremia in human hepatocyte chimeric mice. (2010)
  • Author(s): Tsuge M, Hiraga N, Akiyama R, Tanaka S, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, Takahashi S, Hayes CN, Chayama K.
  • Journal Title: J Gen Virol Volume: 91(pt7) Pages: 1854-1864
  • Peer Reviewed
• [Journal Article] Practical Evaluation of a Mouse with Chimeric Human Liver Model for Hepatitis C Virus Infection Using an NS3-4A Protease Inhibitor. (2010)
  • Author(s): Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K, Chayama K.
  • Journal Title: J Gen Virol Volume: 91 Pages: 1668-1677
  • Peer Reviewed
• [Journal Article] Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan. (2010)
  • Author(s): Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y ; The Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, Ministry of Health, Labor, Welfare of Japan.
  • Journal Title: Hepatol Res Volume: 40(1) Pages: 1-7
  • NAID: 10027406161
  • Peer Reviewed
• [Journal Article] G to A hypermutation of TT virus. (2010)
  • Author(s): Tsuge M, Noguchi C, Akiyama R, Matsushita M, Kunihiro K, Tanaka S, Abe H, Mitsui F, Kitamura S, Hatakeyama T, Kimura T, Miki D, Hiraga N, Imamura M, Takahashi S, Hayses CN, Chayama K
  • Journal Title: Virus Res Volume: 149(2) Pages: 211-216
  • Peer Reviewed
• [Presentation] Biological analysis of hepatitis C virus using human hepatocyte chimeric mouse (2012)
  • Author(s): 茶山一彰
  • Organizer: アジア太平洋肝臓病学会議(APASL)
  • Place of Presentation: 台北、台湾(招待講演)
  • Year and Date: 2012-02-19
• [Presentation] Dual Oral Combination Therapy with the NS5A Inhibitor BMS-790052 and the NS3 Protease Inhibitor BMS-650032 Achieved 90% Sustained Virologic Response(SVR12) in HCV Genotype 1b-Infected Null Responders (2011)
  • Author(s): Chayama Kazuaki
  • Organizer: The 62nd Annual Meeting of American Association for the Study of Liver Diseases(AASLD)
  • Place of Presentation: San Francisco U. S. A.
  • Year and Date: 2011-11-07
• [Presentation] Dual Oral Combination Therapy with the NS5A Inhibitor BMS-790052 and the NS3 Protease Inhibitor BMS-650032 Achieved 90% Sustained Virologic Response (SVR12) in HCV Genotype 1b-Infected Null Responders (2011)
  • Author(s): 茶山一彰
  • Organizer: The 62nd Annual Meeting of American Association for the Study of Liver Diseases (AASLD)
  • Place of Presentation: アメリカ サンフランシスコ(招待講演)
  • Year and Date: 2011-11-07
• [Presentation] Biological analysis of hepatitis viruses using human hepatocyte chimeric mouse (2011)
  • Author(s): 茶山一彰
  • Organizer: 第59回国際歯科研究学会日本部会総会・学術大会(JADR2011)
  • Place of Presentation: 広島(招待講演)
  • Year and Date: 2011-10-09
• [Presentation] Hepatitis C Virus Replication and Response to Anti-viral Drugs in Human Hepatocyte Chimeric Mice (2010)
  • Author(s): 茶山一彰
  • Organizer: 第7回アジア太平洋肝臓病学会議(APASL)シングルトピックカンファレンス
  • Place of Presentation: 千葉市(招待講演)
  • Year and Date: 2010-12-17
• [Presentation] Personalized Medicine in Chronic Hepatitis B (2010)
  • Author(s): Chayama K
  • Organizer: TASL 2020 Single Topic Conference
  • Place of Presentation: 台北(招待講演)
  • Year and Date: 2010-08-22
• [Presentation] IL28の多型とC型慢性肝炎の炎症、繊維化、γGTPとの関連 (2010)
  • Author(s): 阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] C型慢性肝炎患者に対するPegIFN/RBV療法の治療効果とIL28 locusのSNPおよび肝内IFN誘導遺伝子発現量の関連 (2010)
  • Author(s): 阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] HCV関連ミラノ基準内肝細胞癌に対する根治治療後の予後 IFN効果とミラノ基準逸脱時期の検討を含めて (2010)
  • Author(s): 相方浩, 片村嘉男, 橋本義政, 長沖祐子, 河岡友和, 高木慎太郎, 平松憲, 脇浩司, 川上由育, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] 骨転移合併肝細胞癌に対するゾレドロン酸の効果 (2010)
  • Author(s): 片村嘉男, 相方浩, 長沖祐子, 石田友希, 橋本義政, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] Angio-CTでは指摘されずGd-EOB DTPA造影MRI肝細胞相でのみ指摘される結節についての検討 (2010)
  • Author(s): 高木慎太郎, 橋本義政, 長沖祐子, 石田友希, 片村嘉男, 河岡友和, 柘植雅貴, 平松憲, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 相方浩, 高橋祥一, 柿沢秀明, 福田浩, 堀口純, 永田靖, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] HBV RT領域の変異と核酸アナログ耐性への影響 (2010)
  • Author(s): 柘植雅貴, 今村道雄, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] HCV感染マウスを用いたプロテアーゼ阻害剤およびRNAポリメラーゼ阻害剤の抗ウイルス効果の検討 (2010)
  • Author(s): 平賀伸彦, 今村道雄, 岩尾英治, 柘植雅貴, 光井富貴子, 河岡友和, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] HBV感染ヒト肝細胞キメラマウスの血清中及び肝臓中cccDNA量の解析 (2010)
  • Author(s): 石田雄二, 眞田春美, 加国雅和, 島田卓, 茶山一彰, 立野知世
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] C型肝炎ウイルス感染におけるHLA DRB1とNKG2D遺伝子多型の影響 (2010)
  • Author(s): 大石和佳, 吉田健吾, 林奉権, 楠洋一郎, 藤原佐枝子, 柘植雅貴, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 肝細胞癌に対するCDDP/LPDを用いた経カテーテル的化学塞栓術反復療法とステージングシステムについての検討 (2010)
  • Author(s): 河岡友和, 相方浩, 長沖祐子, 橋本義政, 石田友希, 片村嘉男, 光井富貴子, 石飛朋和, 高木慎太郎, 平賀伸彦, 柘植雅貴, 平松憲, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 3cm以下単発、Child A肝細胞癌に対する肝切除とラジオ波焼灼療法の比較 (2010)
  • Author(s): 脇浩司, 相方浩, 長沖祐子, 石田友希, 橋本義政, 片村嘉男, 河岡友和, 高木慎太郎, 平松憲, 今村道雄, 川上由育, 高橋祥一, 田代裕尊, 大段秀樹, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] Genotype1b・高ウイルス量以外のC型慢性肝炎に対するResponse-guided therapy (2010)
  • Author(s): 北本幹也, 井川敦, 松本陽子, 山田博康, 川上由育, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 慢性肝疾患に対する脾臓摘出術の効果と合併症 (2010)
  • Author(s): 田代裕尊, 艮雄一郎, 天野尋暢, 大下彰彦, 小林剛, 谷本新学, 黒田慎太郎, 田澤宏文, 相方浩, 高橋祥一, 茶山一彰, 浅原利正, 板本敏行, 大段秀樹
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 非アルコール性脂肪性肝炎(NASH)における肝線維化と糖代謝異常の関連性について (2010)
  • Author(s): 石田友希, 兵庫秀幸, 石飛朋和, 鍋島由宝, 長沖祐子, 橋本義政, 片村嘉男, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 川上由育, 相方浩, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] NAFLDの肝線維化と血小板数の関係について (2010)
  • Author(s): 石飛朋和, 兵庫秀幸, 鍋島由宝, 石田友希, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 肝移植後C型肝炎再燃に対するIFN治療の現況とSVR率改善のための検討 (2010)
  • Author(s): 河岡友和, 高橋祥一, 田代裕尊, 大段秀樹, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] C型慢性肝炎患者におけるILB28多型とウイルス側および宿主側因子との関連 (2010)
  • Author(s): 今村道雄, 越智秀典, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] B型慢性肝炎の治療 (2010)
  • Author(s): 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-24
• [Presentation] MRIによる肝線維化の評価 (2010)
  • Author(s): 橋本義政, 高木慎太郎, 石井康隆, 川瀬理恵, 小酒慶一, 寺崎元美, 永井健太, 中土井鋼一, 野田育江, 村上英介, 宮木大輔, 長沖祐子, 石田友希, 片村嘉男, 平松憲, 脇浩司, 相方浩, 高橋祥一, 茶山一彰, 福田浩
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-24
• [Presentation] ミラノ基準内Child A、B肝細胞癌症例に対する肝切除、ラジオ波治療後の予後から見た肝移植適応時期の検討 (2010)
  • Author(s): 片村嘉男, 高橋祥一, 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-24
• [Presentation] 当院における生体肝移植ドナーの術後経過および診療の現況 (2010)
  • Author(s): 高木慎太郎, 大段秀樹, 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-23
• [Presentation] C型慢性肝炎に対するインターフェロン治療におけるILB28多型とCore領域変異の影響 (2010)
  • Author(s): 今村道雄, 越智秀典, 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-23
• [Presentation] 肝外転移合併肝細胞癌に対するS1 based全身化学療法の検討 (2010)
  • Author(s): 相方浩, 片村嘉男, 橋本義政, 長沖祐子, 河岡友和, 高木慎太郎, 平松憲, 脇浩司, 川上由育, 高橋祥一, 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-22
• [Presentation] in vitro, in vivoモデルを用いた多剤耐性HBVに対する抗ウイルス効果の検討 (2010)
  • Author(s): 柘植雅貴, 平賀伸彦, 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-22
• [Presentation] B型・C型肝炎合併CKD患者におけるステロイド薬、免疫抑制薬使用に関する考え方 (2010)
  • Author(s): 茶山一彰
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島市(招待講演)
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/naika1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/naikal/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/nbard/biom/saisei.htm
• [Remarks]
  • URL: http://www.src.riken.go.jp/group/liver/index.html