Periodontal bacteria as one of the risk factors for developing of Non-alcoholic steato-hepatitis(NASH)

• Project/Area Number: 22659150
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: ABE Yasunobu 横浜市立大学, 医学部, 助教 (10347312)
• Co-Investigator(Kenkyū-buntansha): NAKAJIMA Atsushi 横浜市立大学, 附属病院, 教授 (30326037) ; WADA Koichiro 大阪大学, 歯学研究科, 准教授 (90263467)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 歯周病 / 非アルコール性脂肪肝炎 / 脂肪肝 / NASH / 口腔内細菌

Research Abstract

The detection frequency of P. gingivalis in NAFLD patients was significantly higher than that in the non-NAFLD control subjects(46.7% vs. 21.7%, odds ratio : 3.16). In addition, the detection frequency of P. gingivalis in NASH patients was markedly higher than that in the non-NAFLD subjects(52.0%, odds ratio : 3.91). Most of the P. gingivalis fimbria detected in the NAFLD patients was of invasive genotypes, especially type II(50.0%). Infection of type II P. gingivalis on NAFLD model of mice accelerated the NAFLD progression. The non-surgical periodontal treatments on NAFLD patients carried out for 3 months ameliorated the liver function parameters, such as the serum levels of AST and ALT.

Research Products

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  • Journal Title: Intern Med Volume: 51(11) Pages: 1301-7
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• [Journal Article] Risk Factors for Colonic Diverticular Hemorrhage : Japanese Multicenter Study (2012)
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  • Journal Title: BMC Gastroenterol Volume: 26 Pages: 12-25
• [Journal Article] Early effects of oral administration of omeprazole and roxatidine on intragastric pH (2012)
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• [Journal Article] A New Non-Invasive Modality for Recording SequentialImages and the pH of the Small Bowel (2012)
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• [Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease (2012)
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• [Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease (2012)
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• [Journal Article] Risk Factors for Colonic Diverticular Hemorrhage : Japanese Multicenter Study (2012)
  • Author(s): Suzuki K, Uchiyama S, Imajyo K, Tomeno W, Sakai E, Yamada E, Tanida E, Akiyama T, Watanabe S, Endo H, Fujita K, Yoneda M, Takahashi H, Koide T, Tokoro C, Abe Y, Kawaguchi M, Gotoh E, Maeda S, Nakajima A, Inamori M
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• [Journal Article] Quantitative analysis of low-dose aspirin-associated small bowel injury using a capsule endoscopy scoring index. (2011)
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• [Journal Article] Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients.A cross sectional study. (2010)
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• [Journal Article] Induction of microsomal triglyceride transfer protein expression is a candidate mechanism by which ezetimibe therapy might exert beneficial effects in patients with nonalcoholic steatohepatitis. (2010)
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• [Presentation] 放射線不透過マーカーを用いた, 健常ボランティアにおけるクエン酸モサプリドによる大腸通過時間改善効果の検討 (2011)
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  • Organizer: 第7回日本消化管学会総会学術集会(オーラルセッション) Function Track 3 下部消化管その他
  • Place of Presentation: 京都市 国立京都国際会館(一般演題)
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• [Presentation] ワークショップ司会 (2011)
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• [Presentation] 内視鏡的胃内バルーン留置術による体重、内臓脂肪、肝容量、L/S比の経時的変化 (2011)
  • Author(s): 関野雄典
  • Organizer: 第7回日本消化管学会総会学術集会 ワークショップ 16 肥満、代謝異常と消化管疾患:病態解明への新たなアプローチ
  • Place of Presentation: 京都市 国立京都国際会館
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• [Presentation] 肥満と大腸癌:大腸腫瘍を増大させるレプチンシグナル (2011)
  • Author(s): 遠藤宏樹
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• [Presentation] 大腸発癌におけるIL-6の作用解析 (2011)
  • Author(s): 内山崇
  • Organizer: 第7回日本消化管学会総会学術集会 ワークショップ 16 肥満、代謝異常と消化管疾患:病態解明への新たなアプローチ
  • Place of Presentation: 京都市 国立京都国際会館
  • Year and Date: 2011-02-19
• [Presentation] カプセル内視鏡による絨毛萎縮の評価:HIV症例を対象に (2011)
  • Author(s): 細野邦広
  • Organizer: 第7回日本消化管学会総会学術集会(オーラ ルセッション) 6 Mucosal Track 2 小腸
  • Place of Presentation: 京都市 国立京都国際会館(一般演題)
  • Year and Date: 2011-02-18
• [Presentation] 酸分泌抑制薬の胃内pHの立ち上がりに関するmosaprideの効果についての検討 (2011)
  • Author(s): 飯田洋
  • Organizer: 第7回日本消化管学会総会学術集会(オーラルセッション) 8 Function Track 2 上部消化管 その他
  • Place of Presentation: 京都市 国立京都国際会館(一般演題)
  • Year and Date: 2011-02-18
• [Presentation] 胃瘻カテーテルの抜去閉鎖を行った症例の検討:問題点の提示 (2011)
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  • Organizer: 第7回日本消化管学会総会学術集会(オーラルセッション)15 Clinical Track 3 PEGその他
  • Place of Presentation: 京都市 国立京都国際会館(一般演題)
  • Year and Date: 2011-02-18
• [Presentation] Helicobacter pylori感染は食道扁平上皮癌のリスクを増加させるか? (2011)
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  • Organizer: 第7回日本消化管学会総会学術集会 ポスターセッション 13 Cancer Track 3
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  • Year and Date: 2011-02-18
• [Presentation] 潰瘍性大腸炎の小腸病変:カプセル内視鏡による検討 (2011)
  • Author(s): 日暮琢磨
  • Organizer: 第7回日本消化管学会総会学術集会 コアシンポジウム2 炎症性腸疾患:UCの病態と治療の新たな展開
  • Place of Presentation: 京都市 国立京都国際会館
  • Year and Date: 2011-02-18
• [Presentation] 慢性偽性腸閉塞症の内科的診断・治療の現状-厚生省研究班のちょうさ結果を踏まえて- (2011)
  • Author(s): 坂本康成
  • Organizer: 第7回日本消化管学会総会学術集会 コアシンポジウム3 機能性消化管疾患:病態にせまる ～運動からみて～
  • Place of Presentation: 京都市 国立京都国際会館
  • Year and Date: 2011-02-18
• [Presentation] 新規大腸化学発癌予防薬としてのResveratrolの可能性新規大腸化学発癌予防薬としてのResveratrolの可能性 (2011)
  • Author(s): 酒井英嗣
  • Organizer: 第7回日本消化管学会総会学術集会 ワークショップ 7 大腸癌の治療、予防に向けた新規標的分子の探索
  • Place of Presentation: 京都市 国立京都国際会館
  • Year and Date: 2011-02-18
• [Presentation] Does Helicobacter pylori infection increase the risk of esophageal squamous cell carcinoma in Japan? (2010)
  • Author(s): Chikako Tokoro
  • Organizer: 18th United European Gastroenterology Week Poster
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-10-27
• [Presentation] Investigation of gastrointestinal tract involvement of small intestine in HIV carrier by capsule endoscopy (2010)
  • Author(s): Kunihiro Hosono.
  • Organizer: European Gastroenterology Week Poster
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-10-26
• [Presentation] 幽門側胃切除術歴とGERD spectrum (2010)
  • Author(s): 秋山智之
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ワークショップ 22.barrett食道癌のサーベイランス・治療を巡って(消化器内視鏡学会・消化器病学会・消化器外科学会合同)
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-15
• [Presentation] 低用量アスピリン関連小腸粘膜障害に対するプロバイオティック療法の有用性:カプセル内視鏡を用いた前向きランダム化比較試験 (2010)
  • Author(s): 遠藤宏樹
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ワークショップ24薬剤起因性小腸病変を巡って-現状と対策(消化器内視鏡学会・消化器病学会合同)
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-15
• [Presentation] 大腸発癌過程におけるTNF-α関連因子の解析 (2010)
  • Author(s): 細野邦広
  • Organizer: 日本消化器関連学会週間(JDDW 2010)パネルディスカッション 18.大腸がん研究の新たな展開と治療戦略(消化器病学会・消化器内視鏡学会・消化器外科学会合同)
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-15
• [Presentation] 内科的ドレナージが奏功した、肝被膜下内胆汁瘻の一例 (2010)
  • Author(s): 高畑彩子
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-15
• [Presentation] 膵癌においてSemaphorin 4Dは腫瘍間質に発現し運動能を制御する (2010)
  • Author(s): 加藤真吾
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-15
• [Presentation] IPMNの多段階発がんにおける腫瘍内IDOとtumor infiltrating lymphocytes(TILs)との関係について (2010)
  • Author(s): 小林規俊
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ワークショップ 14.肝胆膵での上皮内腫瘍:病態解明と治療戦略(肝臓学会・消化器病学会・消化器外科学会合同)
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-14
• [Presentation] Borderline NASHを鑑別する血清診断法の開発 (2010)
  • Author(s): 藤田浩司
  • Organizer: 日本消化器関連学会週間(JDDW 2010)シンポジウム 7.NAFLD/NASHの最近の知見(消化器病学会・肝臓学会・消化吸収学会合同)
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-14
• [Presentation] カプセル内視鏡を用いたHIV感染者の小腸消化管障害の検討 (2010)
  • Author(s): 細野邦広
  • Organizer: 日本消化器関連学会週間(JDDW 2010)パネルディスカッション 8.小腸消化管傷害の現況と治療戦略(消化器病学会・消化器内視鏡学会・消化吸収学会合同)
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-14
• [Presentation] 低分化腺癌と浸潤性微小乳頭癌成分を有した巨大胆管のう胞腺癌の1例 (2010)
  • Author(s): 本多靖
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-14
• [Presentation] R.Puri NASHにおける線維化発症のメカニズムについてIL-13/TGF-βの役割 (2010)
  • Author(s): 島村健
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-14
• [Presentation] Acoustic Radiation Force Impulse imaging(ARFI)とフィブロスキャンを用いたNAFLD患者での肝脂肪化、炎症、線維化の比較検討 (2010)
  • Author(s): 米田正人
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-14
• [Presentation] EUS-FNA後腫瘍の急速な増大を認めた悪性リンパ腫の一例 (2010)
  • Author(s): 宮腰藍衣
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-14
• [Presentation] 自己免疫性膵炎のステロイド投与例、非投与例の長期予後および膵癌合併例の検討 (2010)
  • Author(s): 窪田賢輔
  • Organizer: 日本消化器関連学会週間(JDDW 2010)パネルディスカッション5.自己免疫性膵炎の治療と予後(消化器病学会・肝臓学会合同)
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] 大腸発癌におけるレジスチンおよびTNF-αの相関解析 (2010)
  • Author(s): 高橋宏和
  • Organizer: 日本消化器関連学会週間(JDDW 2010)シンポジウム 6.メタボリック症候群(生活習慣病)における消化と吸収 (消化吸収学会・消化器病学会・肝臓学会合同)
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] ドンペリドンによる胃排出能の変化について:Breath ID systemを用いた連続呼気採取による評価 (2010)
  • Author(s): 坂本康成
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] PPIとH2RAの単回経口投与における胃内pHの立ち上がりに関する検討 (2010)
  • Author(s): 飯田洋
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] 当院で経験した悪性黒色腫の胃転移5症例の検討 (2010)
  • Author(s): 所知加子
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] 慢性偽性腸閉塞症-内科的診断・治療の現状 (2010)
  • Author(s): 坂本康成
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] 慢性偽性腸閉塞(CIP)の外科系施設における実態調査 (2010)
  • Author(s): 正木忠彦
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] 本邦における慢性偽性腸閉塞の121例の症例報告のまとめ (2010)
  • Author(s): 飯田洋
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] 大腸癌治療・予防の新しい分子標的としてのレプチンシグナル経路の解析 (2010)
  • Author(s): 内山崇
  • Organizer: 日本消化器関連学会週間(JDDW 2010)ポスター
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] Early complications following percutaneous endoscopic gastrostomy : Results of use of a new direct technique. (2010)
  • Author(s): Tomoko Koide
  • Organizer: The 4^<th> meeting of the Society of Gastrointestinal Intervention
  • Place of Presentation: Korea
  • Year and Date: 2010-10-08
• [Presentation] endoscopy for percutaneous endoscopic gastrostomy : Results of our expenences. (2010)
  • Author(s): Masahiko Inamori
  • Organizer: The 4^<th> meeting of the Society of Gastrointestinal Intervention
  • Place of Presentation: Korea
  • Year and Date: 2010-10-08
• [Presentation] 酸分泌抑制薬の胃内pHの立ち上がりに関するmosaprideの効果についての検討 (2010)
  • Author(s): 飯田洋
  • Organizer: 第12回日本神経消化器病学会
  • Place of Presentation: 鹿児島市 城山観光ホテル(口演)
  • Year and Date: 2010-10-01
• [Presentation] 膵癌において、Semaphorin 4 Dは腫瘍間質-腫瘍細胞シグナル伝達を介して細胞運動を制御する (2010)
  • Author(s): 加藤真吾
  • Organizer: 第69回日本癌学会学術総会 ポスター
  • Place of Presentation: 大阪市 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] 大腸線種切除後の線種再発予測因子としてのヒトACFの検討 (2010)
  • Author(s): 高橋宏和
  • Organizer: 第69回日本癌学会学術総会 English workshops
  • Place of Presentation: 大阪市 大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] 大腸線種における TNF-α、 TNF-R1、TNF-R2, の発現解析 (2010)
  • Author(s): 細野邦広
  • Organizer: 第69回日本癌学会学術総会 ポスター
  • Place of Presentation: 大阪市 大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] IL-6の過剰発現による化学発癌モデルマウスにおける大腸ポリープの検討 (2010)
  • Author(s): 杉山美智子
  • Organizer: 第69回日本癌学会学術総会 ポスター
  • Place of Presentation: 大阪市 大阪国際会議場
  • Year and Date: 2010-09-22
• [Presentation] レプチンによるStat3経路を介した大腸腫瘍増大の制御 (2010)
  • Author(s): 遠藤宏樹
  • Organizer: 第69回日本癌学会学術総会 ポスター
  • Place of Presentation: 大阪市 大阪国際会議場
  • Year and Date: 2010-09-22
• [Presentation] 大腸腺腫切除後の再発予測因子としてのaberrant crypt fociの検討 (2010)
  • Author(s): 高橋宏和
  • Organizer: 第49回日本消化器がん検診学会総会 シンポジウム2 大腸がん検診における精検受診率の向上の方策
  • Place of Presentation: 沖縄沖縄コンベンションセンター
  • Year and Date: 2010-06-11
• [Presentation] 肝移植後のC型肝炎に対するペグインターフェロン・リバビリン治療の問題点 (2010)
  • Author(s): 斉藤聡
  • Organizer: 第46回日本肝臓学会総会 ポスターセッション45 C型肝炎(臨床)17
  • Place of Presentation: 山形市ホテルメトロポリタン山形
  • Year and Date: 2010-05-28
• [Presentation] 培養細胞におけるHepatitis C virus遺伝子型1bの脂質代謝関連遺伝子の発現に及ぼす影響 (2010)
  • Author(s): 篠原義康
  • Organizer: 第46回日本肝臓学会総会セッション61 C型肝炎(基礎)3
  • Place of Presentation: 山形市ホテルメトロポリタン山形(口演)
  • Year and Date: 2010-05-28
• [Presentation] NASHにおけるERストレス応答亢進機序の解析 (2010)
  • Author(s): 藤田浩司
  • Organizer: 第46回日本肝臓学会総会 パネルディスカッションNASH/NAFLDの病因・病態と予後
  • Place of Presentation: 山形市ホテルメトロポリタン山形
  • Year and Date: 2010-05-28
• [Presentation] 非アルコール性脂肪性肝炎(NASH)の発症・増悪に歯周病菌が関与することのヒトおよび動物モデルを用いた解析 (2010)
  • Author(s): 米田正人
  • Organizer: 第46回日本肝臓学会総会 ポスターセッション52 NASH(臨床)2
  • Place of Presentation: 山形市ホテルメトロポリタン山形
  • Year and Date: 2010-05-28
• [Presentation] 進行肝細胞癌(Clinical stage II, III)に対するTACE/局所併用療法-TACE単独療法との比較 (2010)
  • Author(s): 桐越博之
  • Organizer: 第46回日本肝臓学会総会 ポスターセッション15 肝細胞癌(臨床)3
  • Place of Presentation: 山形市ホテルメトロポリタン山形
  • Year and Date: 2010-05-27
• [Presentation] HDL-free cholesterolとC型慢性肝炎(genotype1・抗ウイルス量)に対する治療抵抗性との関係 (2010)
  • Author(s): 馬渡弘典
  • Organizer: 第46回日本肝臓学会総会 ポスターセッション12C型肝炎(臨床)12
  • Place of Presentation: 山形市ホテルメトロポリタン山形
  • Year and Date: 2010-05-27
• [Presentation] 分枝型IPMN診断におけるEUSの役割について (2010)
  • Author(s): 小林規俊
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: 東京グランドプリンスホテル新高輪(口演)
  • Year and Date: 2010-05-15
• [Presentation] 選択的胆管挿管困難例に対するNeedle Knifeを用いたPrecutting-Small Incision and Layer by Layer Method- (2010)
  • Author(s): 窪田賢輔
  • Organizer: 第79回日本消化器内視鏡学会総会 シンポジウム6
  • Place of Presentation: 東京グランドプリンスホテル新高輪
  • Year and Date: 2010-05-14
• [Presentation] 内視鏡的胃ろう造設術後の早期合併症の検討:造設方法の差異を中心に (2010)
  • Author(s): 古出智子
  • Organizer: 第79回日本消化器内視鏡学会総会 パネルディスカッション
  • Place of Presentation: 東京グランドプリンスホテル新高輪
  • Year and Date: 2010-05-14
• [Presentation] 経鼻内視鏡における最適なルートの検討 (2010)
  • Author(s): 細野邦広
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: 東京グランドプリンスホテル新高輪(口演)
  • Year and Date: 2010-05-14
• [Presentation] 当科における内視鏡的十二指腸乳頭部腫瘍切除術の検討 (2010)
  • Author(s): 渡邉誠太郎
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: 東京グランドプリンスホテル新高輪(口演)
  • Year and Date: 2010-05-14
• [Presentation] 当院おけるカプセル内視鏡検査の工夫:診断率向上のためのより良質な検査のために (2010)
  • Author(s): 遠藤宏樹
  • Organizer: 第79回日本消化器内視鏡学会総会シンポジウム
  • Place of Presentation: 東京グランドプリンスホテル新高輪
  • Year and Date: 2010-05-13
• [Presentation] 特異な画像を呈し、診断が困難であった肝内胆管癌の一例 (2010)
  • Author(s): 加藤真吾
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: 東京グランドプリンスホテル新高輪(口演)
  • Year and Date: 2010-05-13
• [Presentation] 内視鏡的治療からみた悪性胆管狭窄と良性胆管狭窄の違い～肝移植後胆管狭窄症例を中心に～ (2010)
  • Author(s): 小林規俊
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: 東京グランドプリンスホテル新高輪(口演)
  • Year and Date: 2010-05-13
• [Presentation] HIV感染者における小腸病変の実態 (2010)
  • Author(s): 細野邦広
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: 東京グランドプリンスホテル新高輪
  • Year and Date: 2010-05-13
• [Presentation] Relationship Between the Location of Colonic Diverticulosis and the Visceral Fat Accumulation.Crucial Role of the Visceral Fat Accumulation for the Formation of Left Sided Colonic. (2010)
  • Author(s): Watanabe S
  • Organizer: Diverticulosis DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-05
• [Presentation] Capsule Endoscopy Findings in the Small Intestine of HIV Carrier. (2010)
  • Author(s): Hosono K
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-05
• [Presentation] FOXP3+ Regulatory T Cells and Tumoral Indoleamine 2, 3-Dioxygenase Expression Predicts the Carcinogenesis of the Pancreas. (2010)
  • Author(s): Kobayashi N
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-04
• [Presentation] Mucus Nodule of the Endoscopic Ultrasonographic Finding is One of the Most Important Diagnostic Factors of the Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas. (2010)
  • Author(s): Kobayashi N
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-04
• [Presentation] A New Noninvasive Modality for Recording Sequential Images and the pH of the Small Bowel. (2010)
  • Author(s): Iida H
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-04
• [Presentation] HDL-Free Cholesterol is an Independent Clinical Marker of the Resistanee to Hepatitis C Treatment. (2010)
  • Author(s): Mawatari H
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-04
• [Presentation] FOXP3 Upregulation in Biopsy Specimens of the Duodenal Papilla Has Prognostic Significance in Cases With Ampullary Tumors. (2010)
  • Author(s): Kubota K
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-03
• [Presentation] Endoscopic Biopsy Using FOXP3+Treg and IgG4 up-Regulation in the Duodenal Papilla to Improve the Sensitivity of Diagnosing Autoimmune Pancreatitis Even in IgG4-Seronegative Patients. (2010)
  • Author(s): Kubota K
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-03
• [Presentation] A.Duodenal Papillitis Represents "Other Organ Involvement" in Autoimmune Pancreatitis (2010)
  • Author(s): Kubota K
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-03
• [Presentation] Overexpression of Interleukin-13 Receptor-Alpha2 in Pancreatic Ductal Adenocarcinoma : A Novel Target for Receptor Directed Anti-Cancer Therapy. (2010)
  • Author(s): Shimamura T
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-03
• [Presentation] Critical Role of Leptin in the Regulation of Colorectal Tumor Growth Through STAT3 Signaling : Tumor Growth Induced byDietary Intake. (2010)
  • Author(s): Endo H
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-02
• [Presentation] Cd100/Sema4d : A Lymphocyte Semaphorin Involved in the Regulation of Cell Motility in Pancreatic Cancer. (2010)
  • Author(s): Kato S
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-02
• [Presentation] Crucial Role of C-Jun N-Terminal Kinase (JNK) in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH) (2010)
  • Author(s): Fujita K
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-02
• [Presentation] Endothelial Nitric Oxide Synthase Changes the Fat Distribution in High-Fat Diet-Induced NAFLD Mice. (2010)
  • Author(s): Nozaki Y
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-02
• [Presentation] Combined Transarterial Chemoembolization (TACE) and Percutaneous Local Ablation Therapy for Advanced Hepatocellular Carcinoma (HCC). (2010)
  • Author(s): Kirikoshi H
  • Organizer: DIGESTIVE DISEASE WEEK ORAL SESSIONS Poster Session
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-02
• [Presentation] 酸分泌抑制薬の前投与によるHelicobacter pyloriの除菌率への影響:プロトンポンプ阻害薬とH2受容体拮抗薬の差異は? (2010)
  • Author(s): 所知加子
  • Organizer: 第96回日本消化器病学会総会H.Pylori-2
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-24
• [Presentation] 当院における上部消化管出血症例の危険群の予測についての検討 (2010)
  • Author(s): 高畑彩子
  • Organizer: 第96回日本消化器病学会総会 消化管出血-2
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-24
• [Presentation] カプセル内視鏡で確認した潰瘍性大腸炎の小腸病変 (2010)
  • Author(s): 日暮琢磨
  • Organizer: 第96回日本消化器病学会総会ポスター小腸症例-3
  • Place of Presentation: 新潟 朱鷺メッセ
  • Year and Date: 2010-04-24
• [Presentation] 膵臓がん新規分子標的治療薬(IL-13PE : Cintredekin Besudotox)の開発・検討 (2010)
  • Author(s): 嶌村健
  • Organizer: 第96回日本消化器病学会総会パネルディスカッション10:膵癌の治療成績向上をめざして
  • Place of Presentation: 新潟 新潟県民会館
  • Year and Date: 2010-04-24
• [Presentation] なぜ, 今, 消化器病研究に肥満が重要か?トピックスセミナー(第28回日本医学会総会プレシンポジウム)司会 (2010)
  • Author(s): 中島淳
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟 新潟県民会館
  • Year and Date: 2010-04-24
• [Presentation] 肥満と大腸がん (2010)
  • Author(s): 中島淳、高橋宏和
  • Organizer: 第96回日本消化器病学会総会 なぜ, 今, 消化器病研究に肥満が重要か?トピックスセミナー(第28回日本医学会総会プレシンポジウム)
  • Place of Presentation: 新潟 新潟県民会館
  • Year and Date: 2010-04-24
• [Presentation] 当科における非B非C型肝細胞癌の臨床的特徴-ウイルス性、アルコール性、非B非C型の比較 (2010)
  • Author(s): 桐越博之
  • Organizer: 第96回日本消化器病学会総会肝癌
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-23
• [Presentation] 酸分泌抑制薬と胃許容能、胃排出能について-飲水試験、呼気試験を用いた検討- (2010)
  • Author(s): 坂本康成
  • Organizer: 第96回日本消化器病学会総会胃・十二指腸
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-23
• [Presentation] 非侵襲的かつ連続的に小腸の画像とpHを同時に測定する機器「pHカプセル」の開発 (2010)
  • Author(s): 飯田洋
  • Organizer: 第96回日本消化器病学会総会 パネルディスカッション8:小腸疾患の診断と治療法の進歩
  • Place of Presentation: 新潟 新潟県民会館
  • Year and Date: 2010-04-23
• [Presentation] 大腸憩室出血症例の検討 (2010)
  • Author(s): 鈴木香峰理
  • Organizer: 第96回日本消化器病学会総会ポスター大腸症例-1
  • Place of Presentation: 新潟 朱鷺メッセ
  • Year and Date: 2010-04-23
• [Presentation] 便潜血陽性を契機にカプセル内視鏡により発見されたバイアスピリン起因性小腸潰瘍の1例 (2010)
  • Author(s): 酒井英嗣
  • Organizer: 第96回日本消化器病学会総会ポスター小腸臨床-3
  • Place of Presentation: 新潟 朱鷺メッセ
  • Year and Date: 2010-04-23
• [Presentation] 胃原発リンパ上皮腫様癌の1例 (2010)
  • Author(s): 谷口礼央
  • Organizer: 第96回日本消化器病学会総会ポスター胃悪性-1
  • Place of Presentation: 新潟 朱鷺メッセ
  • Year and Date: 2010-04-23
• [Presentation] 食事摂取により増大する大腸腫瘍:レプチンシグナルの関与 (2010)
  • Author(s): 遠藤宏樹
  • Organizer: 第96回日本消化器病学会総会 シンポジウム6:消化器がんと栄養療法
  • Place of Presentation: 新潟 新潟市民芸術文化会館
  • Year and Date: 2010-04-23
• [Presentation] GERD spectrumと肥満、内臓脂肪、液性因子の関与 (2010)
  • Author(s): 秋山智之
  • Organizer: 第96回日本消化器病学会総会GERD-3
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-22
• [Presentation] 超高齢者に対する内視鏡的胃ろう造設術の経験 (2010)
  • Author(s): 池田多聞
  • Organizer: 第96回日本消化器病学会総会PEG
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-22
• [Presentation] 内視鏡的胃ろう造設術後の出血に関する検討 (2010)
  • Author(s): 古出智子
  • Organizer: 第96回日本消化器病学会総会PEG
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-22
• [Presentation] 肝腫瘍、膵腫瘍の予後因子としてのFOXP3+制御性T細胞について (2010)
  • Author(s): 小林規俊
  • Organizer: 第96回日本消化器病学会総会膵基礎-2
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-22
• [Presentation] 当院における分枝型IPMNの切除例および経過観察例の検討 (2010)
  • Author(s): 小林規俊
  • Organizer: 第96回日本消化器病学会総会IPMN
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-22
• [Presentation] 一酸化窒素(NO)はNAFL形成を促進させるが、 NASH進展を抑制する;NAFLD病態におけるNOの多様な作用とその機序について (2010)
  • Author(s): 野崎雄一
  • Organizer: 第96回日本消化器病学会総会NASH基礎
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-22
• [Presentation] NAFLDと肝血流:eNOSは体内脂肪分布を制御する (2010)
  • Author(s): 野崎雄一
  • Organizer: 第96回日本消化器病学会総会NAFLD基礎
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-22
• [Presentation] 膵癌におけるSema4D-PlexinB1 signal pathwaの機能解析 (2010)
  • Author(s): 加藤真吾
  • Organizer: 第96回日本消化器病学会総会 膵基礎-1
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-22
• [Presentation] NASH患者に対するエゼチミブの有用性-6ヶ月投与による肝組織改善効果のパイロットスタディー (2010)
  • Author(s): 米田正人
  • Organizer: 第96回日本消化器病学会総会NAFLD臨床
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-22
• [Presentation] 大腸憩室症の存在部位と内臓脂肪との関連性についての検討 (2010)
  • Author(s): 渡邉誠太郎
  • Organizer: 第96回日本消化器病学会総会 大腸良性-3
  • Place of Presentation: 新潟 新潟県民会館(口演)
  • Year and Date: 2010-04-22
• [Presentation] 大腸腫瘍におけるレプチンシグナル経路の解析 (2010)
  • Author(s): 内山崇
  • Organizer: 第96回日本消化器病学会総会ワークショップ3:NASH□NAFLD発症のメカニズム
  • Place of Presentation: 新潟 新潟市民芸術文化会館
  • Year and Date: 2010-04-22
• [Presentation] JNKシグナルを介したNASH発症メカニズムの解析 (2010)
  • Author(s): 藤田浩司
  • Organizer: 第96回日本消化器病学会総会 ワークショップ3:NASH□NAFLD発症のメカニズム
  • Place of Presentation: 新潟 新潟市民芸術文化会館
  • Year and Date: 2010-04-22
• [Presentation] 腎癌術後15年目に転移性膵腫瘍を認めた2症例 (2010)
  • Author(s): 大久保秀則
  • Organizer: 第96回日本消化器病学会総会ポスター膵腫瘍-1
  • Place of Presentation: 新潟 朱鷺メッセ
  • Year and Date: 2010-04-22
• [Presentation] 内視鏡的ドレナージが奏功した腸間膜GISTの腫瘍内感染の一例 (2010)
  • Author(s): 小島拓人
  • Organizer: 第96回日本消化器病学会総会ポスターその他消化管悪性-2
  • Place of Presentation: 新潟 朱鷺メッセ
  • Year and Date: 2010-04-22
• [Presentation] 肝細胞がんの肝移植の適応について(内科の立場から) (2010)
  • Author(s): 斉藤聡
  • Organizer: 第96回日本消化器病学会総会ポスター肝移植
  • Place of Presentation: 新潟 朱鷺メッセ
  • Year and Date: 2010-04-22
• [Presentation] 大腸腫瘍進展における糖尿病関連因子の相関解析 (2010)
  • Author(s): 高橋宏和
  • Organizer: 第96回日本消化器病学会総会ポスター大腸悪性臨床-5
  • Place of Presentation: 新潟 朱鷺メッセ
  • Year and Date: 2010-04-22
• [Presentation] 大腸癌における生活習慣関連因子の実態と化学予防による対策の可能性 (2010)
  • Author(s): 細野邦広
  • Organizer: 第96回日本消化器病学会総会パネルディスカッション2:生活習慣病としての消化器疾患の実態と対策
  • Place of Presentation: 新潟 新潟県民会館
  • Year and Date: 2010-04-22
• [Presentation] 難治性胃食道逆流症の治療戦略 (2010)
  • Author(s): 稲森正彦
  • Organizer: 第96回日本消化器病学会総会 パネルディスカッション4:難治性GERDの治療戦略
  • Place of Presentation: 新潟 新潟県民会館
  • Year and Date: 2010-04-22
• [Presentation] CAN WE DISCRIMINATE BETWEEN"MANPUKU"(SATIETY)AND"BOUMAN"(EPIGASTRIC BLOATING)? (2010)
  • Author(s): Y Sakamoto
  • Organizer: 2010 NGM Joint Meeting Poster
  • Place of Presentation: Boston, USA
• [Presentation] EARIY EFFECTS OF ORAL ADMINISTRATIONS OF OMEPRAZOLE WITH MOSAPRIDE ON INTRAGASTRIC PH. (2010)
  • Author(s): H Iida
  • Organizer: 2010 NGM Joint Meeting Poster
  • Place of Presentation: Boston, USA
• [Presentation] SERUM FREE CHOLINE IS A NOVEL NON-INVASIVE BIOMARKER FOR DETECTING BORDERLINE NASH : A MULT1-CENTER VALIDATION STUDY. (2010)
  • Author(s): Koji Fujita
  • Organizer: AASLD
  • Place of Presentation: Boston, USA
• [Presentation] THE ER STRESS CAUSED BY HEPATITIS C VIRUS IN REPLICON CELLS WAS REVERSED BY INTERFERON TREATMENT. (2010)
  • Author(s): Yoshiyasu Shinohara
  • Organizer: AASLD
  • Place of Presentation: Boston, USA
• [Presentation] HEPATIC TRIGLYCERIDE LIPASE MAY PLAY IMPORTANT ROLE TOCHANGE THE LIPOPROTEIN PROFILES IN THE HCV REPLICON SYSTEM. (2010)
  • Author(s): Yoshiyasu Shinohara
  • Organizer: AASLD
  • Place of Presentation: Boston, USA
• [Presentation] DECREASE IN HEPATIC MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN MRNA LEVELS AND PATHOLOGl CAL PROGRESSION INDUCED BY LIPOPOLYSACCHARIDE IN A MURINE NASH MODEL. (2010)
  • Author(s): Kento Imajo
  • Organizer: AASLD
  • Place of Presentation: Boston, USA
• [Presentation] Relationship of human rectal aberrant crypt foci and formation of colorectal polyp. (2010)
  • Author(s): Hirokazu Takahashi
  • Organizer: Frontiers in Cancer Prevention Research 2010, Poster
  • Place of Presentation: Philadelphia, USA
• [Presentation] Metformin treatment suppresses colorectal aberrant crypt foci in humans : Results from a short-term feasibility study. (2010)
  • Author(s): Kunihiro Hosono
  • Organizer: Frontiers in Cancer Prevention Research 2010, Poster
  • Place of Presentation: Philadelphia, USA
• [Presentation] The effect of resveratrol on azoxymethane (AOM)-induced colon carcinogenesis in mice with aberrant crypt foci (ACF). (2010)
  • Author(s): Eiji Sakai
  • Organizer: Frontiers in Cancer Prevention Research 2010, Poster
  • Place of Presentation: Philadelphia, USA
• [Presentation] EUS-Guided Biliary Drainage for Malignant Biliary Duct Obstruction : Yokohama City University Experience. (2010)
  • Author(s): Kensuke Kubota
  • Organizer: 2010 EUS
  • Place of Presentation: 上海China
• [Presentation] Non Invasive Diagnosis of NAFLD. (2010)
  • Author(s): Atsushi Nakajima
  • Organizer: the 9^<th> JSH Single Topic Conference"NASH 2010"
  • Place of Presentation: 東京 グランドプリンスホテル高輪(招待講演)