A significance of integrated stress response in the heart
| Project/Area Number |
22659158
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
SANO Motoaki 慶應義塾大学, 医学部, 講師 (30265798)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | ストレス応答 / 心不全 / 心筋代謝 |
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| Research Abstract |
We created and analyzed αMHC-Fv2E-PERK mice(an inducible eIF2α activator mice) and α MHC-Gadd34C mice(a loss of function model of eIF2α). Notably, the strong activation of eIF2αtriggered by dimerization of PERK transiently suppressed left ventricular systolic function. Left ventricular systolic function was gradually recovered in survivor mice. The strong activation of eIF2α was observed in the severe ischemia. Therefore, we hypothesized that the transient impairment of left ventricular systolic function is resemble to stunned myocardium. We are currently investigating the underlying mechanism of the transient impairment of left ventricular systolic function.
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Report
(3 results)
Research Products
(17 results)
