Identification of alveolar cell induction genes and differentiation of iPS cells into alveolar cells
| Project/Area Number |
22659160
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hirosaki University |
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Principal Investigator |
SAIJYO Yasuo 弘前大学, 大学院・医学研究科, 教授 (10270828)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,060,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / その他 / iPS細胞 / 肺細胞II型細胞 / 分化 / 肺幹細胞 / 肺胞上皮細胞 |
|---|
| Research Abstract |
In this study, we tried to differentiate mouse iPS cells to alveolar cells in vitro. At first, iPS cells were cultured with ActinA and Wnt3a for 7 days. iPS cells differentiated into endodermal cells expressing Sox17 and Foxa2. iPS cells were further cultured with FGF2 for additional 5 days. Finally, about 8 % iPS cells differentiated into alveolar type II cells determined by SP-C expression and electron microscopy.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Low-dose gefitinib treatment for patients with advanced non-small cell lung cancer harboring sensitive epidermal growth factor receptor mutations2011
Author(s)
Satoh H, Inoue A, Kobayashi K, Maemondo M, Oizumi S, Isobe H, Gemma A, Saijo Y, Yoshizawa H, Hagiwara K, Nukiwa T
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Journal Title
J Thorac Oncol
Volume: 6(8)
Issue: 8
Pages: 1413-7
DOI
Related Report
Peer Reviewed
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[Journal Article] North-East Japan Study Group. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR2010
Author(s)
Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando M, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Morita S, Nukiwa T
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Journal Title
N Engl J Med
Volume: 362(25)
Issue: 25
Pages: 2380-8
DOI
Related Report
Peer Reviewed
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