| Project/Area Number |
22659161
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Nobuhiro 宮崎大学, 医学部, 助教 (70418838)
YANAGI Shigehisa 宮崎大学, 医学部, 助教 (60404422)
MIYOSHI Kahori 宮崎大学, 医学部, 医員 (50573375)
TSUBOUCHI Hironobu 宮崎大学, 医学部, 医員 (60573988)
今井 光一 宮崎大学, 医学部, 助教 (00404426)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,260,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | グレリン / 肺癌 / 漢方薬 / 慢性呼吸不全 / 肺傷害 / Pten / QOL / カヘキシア / エネルギー代謝 |
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| Research Abstract |
In this study, we explored the pathophysiological significance of ghrelin in intractable respiratory diseases. From clinical view, we found an inverse correlation between plasma ghrelin levels at pre-chemotherapy point and degree of chemotherapy-related decline of QOL score in patients with advanced lung cancer. We also found beneficial effects of ghrelin treatment on nutritional status and exercise tolerance in patients with chronic respiratory failure. In animal models, ghrelin administration definitively rescued bleomycin-treated mice in a dose-dependent manner. Ghrelin treatment ameliorated lung inflammation, lung fibrosis and apoptosis of alveolar epithelial cells after lung injury. These results indicate that ghrerin might be an attractive therapeutic strategy against these refractory lung diseases.
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