Role of amine-carbonyl reaction as a novel mechanism for renal disease

• Project/Area Number: 22659164
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Tohoku University
• Principal Investigator: ITO Sadayoshi 東北大学, 大学院・医学系研究科, 教授 (40271613)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: アミン / カルボニル / 慢性腎臓病 / 急性腎障害 / カルボニル物質 / 酸化ストレス / メチルグリオキサール / 尿酸

Research Abstract

The study was designed to evaluate whether reaction between amine and carbonyl compound is a novel mechanism for renal injury. Renal injury was observed by co-administration of MGO and melamine or oxonic acid. This reaction was also inhibited by pyridoxamine treatment. These results indicate that amine-carbonyl reaction could be a novel therapeutic mechanism which could be targeted for renal injuries.

Research Products

• [Journal Article] Uric Acid and Patients Outcomes in a Cohort of Chronic Kidney Disease and Hypertension (2012)
  • Author(s): Masaaki Nakayama、Sadayoshi Ito, 他9名
  • Journal Title: The Gonryo Study Nephrol Dial Transplant Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats (2012)
  • Author(s): Qi Guo、Takefumi Mori、Sadayoshi Ito, 他7名
  • Journal Title: Hypertens Res Volume: 35巻 Pages: 48-54
  • NAID: 10030642820
  • Peer Reviewed
• [Journal Article] Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats (2012)
  • Author(s): Guo Q, 他
  • Journal Title: Hypertens Res Volume: 35 Issue: 1 Pages: 48-54
  • DOI: 10.1038/hr.2011.140
  • Peer Reviewed
• [Journal Article] Uric Acid and Patients Outcomes in a Cohort of Chronic Kidney Disease and Hypertension ; The Gonryo Study (2012)
  • Author(s): Nakayama M, 他
  • Journal Title: Nephrol Dial Transplant Volume: (未定)(In Press)
  • Peer Reviewed
• [Journal Article] Peritoneal clearance and transport of methylglyoxal (2011)
  • Author(s): Hiroyuki Terawaki、Sadayoshi Ito, 他10名
  • Journal Title: Nephrol Dial Transplant Volume: 26巻 Pages: 753-764
  • Peer Reviewed
• [Journal Article] ROADMAP Trial Investigators : Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes (2011)
  • Author(s): Hermann Haller、Sadayoshi Ito, 他10名
  • Journal Title: The NEW ENGLAND JOURNAL of MEDICINE Volume: 364巻 Pages: 907-917
  • Peer Reviewed
• [Journal Article] AKI発症と酸化/カルボニルストレス (2011)
  • Author(s): 森建文、伊藤貞嘉, 他2名
  • Journal Title: Modern Physician Volume: 30(1) Pages: 30-33
• [Journal Article] 腎障害と尿酸 (2011)
  • Author(s): 伊藤貞嘉
  • Journal Title: 血圧 Volume: 18(7) Pages: 622-626
• [Journal Article] 腎血流、今月の特集・理解のためのチェックリスト (2011)
  • Author(s): 伊藤貞嘉
  • Journal Title: 月刊循環器Circulation Volume: 2(2) Pages: 40-49
• [Journal Article] Intake of water with high levels of dissolved hydrogen (H2)suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats (2011)
  • Author(s): Wan-Jun Zhu、Takefumi Mori、Sadayoshi Ito, 他6名
  • Journal Title: Nephrol Dial Transplant Volume: 26巻 Pages: 2112-2118
  • Peer Reviewed
• [Journal Article] Peritoneal clearance and transport of methylglyoxal (2011)
  • Author(s): Terawaki H, 他
  • Journal Title: Nephrol Dial Transplant Volume: 26 Issue: 2 Pages: 753-764
  • DOI: 10.1093/ndt/gfq698
  • Peer Reviewed
• [Journal Article] Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes (2011)
  • Author(s): Ogawa S, 他
  • Journal Title: Tohoku J Exp Med Volume: 223(2) Pages: 133-135
  • Peer Reviewed
• [Journal Article] Intake of water with high levels of dissolved hydrogen (H_2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats (2011)
  • Author(s): Zhu WJ, 他
  • Journal Title: Nephrol Dial Transplant Volume: 26 Issue: 7 Pages: 2112-2118
  • DOI: 10.1093/ndt/gfq727
  • Peer Reviewed
• [Journal Article] Peritoneal clearance and transport of methylglyoxal. (2011)
  • Author(s): Hiroyuki Terawaki
  • Journal Title: Nephrol Dial Transplant Volume: 26(2) Pages: 133-135
  • Peer Reviewed
• [Journal Article] ROADMAP Trial Investigators: Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes (2011)
  • Author(s): Hermann Haller
  • Journal Title: The NEW ENGLAND JOURNAL of MEDICINE Volume: 364 Pages: 907-917
  • Peer Reviewed
• [Journal Article] Methylglyoxal Is a Predictor in Type 2 Diabetic Patients of Intima-Media Tickening and Elevation of Blood Pressure (2010)
  • Author(s): Susumu Ogawa、Takefumi Mori、Sadayoshi Ito, 他7名
  • Journal Title: Hypertension Volume: 56(3) Pages: 471-476
  • Peer Reviewed
• [Journal Article] Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells (2010)
  • Author(s): Noriko Miyazawa、Sadayoshi Ito, 他5名
  • Journal Title: Free Radic Res Volume: 44(1) Pages: 101-107
  • Peer Reviewed
• [Journal Article] Different clinical outcomes for cardiovascular events and mortality in chronic kidney disease according to underlying renal disease : the Gonryo study (2010)
  • Author(s): Masaaki Nakayama、Sadayoshi Ito, 他15名
  • Journal Title: Clin Exp Nephrol Hypertension Volume: 14(4) Pages: 333-339
  • NAID: 10027706697
  • Peer Reviewed
• [Journal Article] The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides (2010)
  • Author(s): Michiaki Abe、Sadayoshi Ito, 他20名
  • Journal Title: Drug Metab Pharmacokinet Volume: 25(3) Pages: 274-285
  • NAID: 10027582905
  • Peer Reviewed
• [Journal Article] Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes (2010)
  • Author(s): Susumu Ogawa、Takefumi Mori、Sadayoshi Ito, 他4名
  • Journal Title: the Tohoku Journal of Experimental Medicine Volume: 223(2) Pages: 133-135
  • NAID: 10027806959
  • Peer Reviewed
• [Journal Article] Aliskiren reduces albuminuria and oxidative stress, and elevates glomerular filtration rates in Japanese patients with advanced diabetic nephropathy (2010)
  • Author(s): Susumu Ogawa、Takefumi Mori、Sadayoshi Ito, 他3名
  • Journal Title: Hypertens Res Volume: 34(3) Pages: 400-401
  • NAID: 10031163188
  • Peer Reviewed
• [Journal Article] Metabolomic profiling of uremic solutes in CKD patients (2010)
  • Author(s): Takafumi Toyohara、Sadayoshi Ito, 他13名
  • Journal Title: Hypertens Res Volume: 33(9) Pages: 944-952
  • NAID: 10026711269
  • Peer Reviewed
• [Journal Article] Methylglyoxal Is a Predictor in Type 2 Diabetic Patients of Intima-Media Tickening and Elevation of Blood Pressure. (2010)
  • Author(s): Susumu Ogawa
  • Journal Title: Hypertension Volume: 56(3) Pages: 471-476
  • Peer Reviewed
• [Journal Article] Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells. (2010)
  • Author(s): Noriko Miyazawa
  • Journal Title: Free Radic Res Volume: 44(1) Pages: 101-107
  • Peer Reviewed
• [Journal Article] Different clinical outcomes for cardiovascular events and mortality in chronic kidney disease according to underlying renal disease : the Gonryo study. (2010)
  • Author(s): Masaaki Nakayama
  • Journal Title: Clin Exp Nephrol Hypertension Volume: 14(4) Pages: 333-339
  • Peer Reviewed
• [Journal Article] The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. (2010)
  • Author(s): Michiaki Abe
  • Journal Title: Drug Metab Pharmacokinet Volume: 25(3) Pages: 274-282
  • Peer Reviewed
• [Journal Article] Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes. (2010)
  • Author(s): Susumu Ogawa
  • Journal Title: the Tohoku Journal of Experimental Medicine. Volume: 223(2) Pages: 133-135
  • Peer Reviewed
• [Journal Article] Aliskiren reduces albuminuria and oxidative stress, and elevates glomerular filtration rates in Japanese patients with advanced diabetic nephropathy. (2010)
  • Author(s): Susumu Ogawa
  • Journal Title: Hypertens Res Volume: 34(3) Pages: 400-401
  • Peer Reviewed
• [Journal Article] Metabolomic profiling of uremic solutes in CKD patients. (2010)
  • Author(s): Toshifumi Toyohara
  • Journal Title: Hypertens Res Volume: 33(9) Pages: 944-952
  • Peer Reviewed
• [Presentation] メチルグリオキサールによる腹膜線維化と機能低下に対するGLO-1の役割 (2012)
  • Author(s): 大場郁子, 他
  • Organizer: 第41回日本心脈管作動物質学会
  • Place of Presentation: 秋田
  • Year and Date: 2012-02-11
• [Presentation] グルコースによる尿細管上皮細胞のミトコンドリア内酸化ストレス亢進機序 (2012)
  • Author(s): 芦毅, 他
  • Organizer: 第41回日本心脈管作動物質学会
  • Place of Presentation: 秋田
  • Year and Date: 2012-02-10
• [Presentation] 高血圧・代謝疾患領域での臨床応用 (2011)
  • Author(s): 森建文
  • Organizer: 第21回日本メイラード学会年会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-28
• [Presentation] 高血圧・代謝疾患領域での臨床応用 (2011)
  • Author(s): 森建文
  • Organizer: 第21回日本メイラード学会年会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] 心腎連関と尿酸 (2011)
  • Author(s): 伊藤貞嘉
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-10-22
• [Presentation] 心腎連関と尿酸 (2011)
  • Author(s): 伊藤貞嘉
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 宇都宮(招待講演)
  • Year and Date: 2011-10-22
• [Presentation] リアルタイムイメージングによる腎尿細管上皮細胞のブドウ糖誘導性ミトコンドリア内酸化ストレスの検討 (2011)
  • Author(s): 芦毅, 他
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木
  • Year and Date: 2011-10-21
• [Presentation] 若年肥満者における尿中カルボニル物質による血圧上昇の予測 (2011)
  • Author(s): 佐藤恵美子, 他
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木
  • Year and Date: 2011-10-21
• [Presentation] 糖尿病腎症におけるRAS抑制の有効性と限界 (2011)
  • Author(s): 伊藤貞嘉
  • Organizer: 第41回日本腎臓学会東部学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-15
• [Presentation] 糖尿病腎症におけるRAS抑制の有効性と限界 (2011)
  • Author(s): 伊藤貞嘉
  • Organizer: 第41回日本腎臓学会東部学術大会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-10-15
• [Presentation] 若年高血圧における尿中酸化/カルボニルストレスおよび炎症マーカーの確立 (2011)
  • Author(s): 森建文, 他
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-27
• [Presentation] 若年高血圧における尿中酸化/カルボニルストレスおよび炎症マーカーの確立 (2011)
  • Author(s): 森建文
  • Organizer: 弟11回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-27
• [Presentation] 慢性腎臓病の心腎血管障害に対するカルボニルストレスの役割 (2010)
  • Author(s): 森建文
  • Organizer: 第40回日本腎臓学会東部学術大会
  • Place of Presentation: 栃木
  • Year and Date: 2010-09-24
• [Presentation] Drug discovery and development from the academia targeting carbonyl stress in renal disease (2010)
  • Author(s): Takefumi Mori
  • Organizer: International Forum on Advances in Diabetes Complications
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2010-07-18
• [Presentation] Drug discovery and development from the academia targeting carbonyl stress in renal disease. (2010)
  • Author(s): Takefumi Mori
  • Organizer: International Forum on Advances in Diabetes Complications
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2010-07-18
• [Presentation] 高尿酸血症に伴った腎障害に対するカルボニルストレスの役割 (2010)
  • Author(s): 郭其, 他
  • Organizer: 第53回日本腎臓学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] 5/6腎摘除慢性腎不全モデルラットにおける運動とolmesartanの腎保護作用に対するカルボニルストレスの役割 (2010)
  • Author(s): 郭其, 他
  • Organizer: 第53回日本腎臓学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] Pyridoxamine ameliorates glomerular injury in rat experimental chronic glomerulonephritis. (2010)
  • Author(s): Takashi Nakamichi
  • Organizer: The 12^<th> Asian Pacific Congress of Nephrology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-07
• [Presentation] The protective effects of pyridoxamine on methylglyoxal-and melamineinduced renal injury (2010)
  • Author(s): Qi Guo, 他
  • Organizer: The 12th Asian Pacific Congress of Nephrology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-05
• [Presentation] The protective effects of pyridoxamine on methylglyoxal- and melamineinduced renal injury. (2010)
  • Author(s): Qi Guo
  • Organizer: The 12^<th> Asian Pacific Congress of Nephrology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-05
• [Presentation] Pyridoxamine ameliorates glomerular injury in rat experimental chronic glomerulonephritis (2010)
  • Author(s): Takashi Nakamichi, 他
  • Organizer: The 12th Asian Pacific Congress of Nephrology
  • Place of Presentation: Seoul, Korea
• [Book] 糖尿病慢性合併症(大血管症); 内分泌・糖尿病内科学 (2011)
  • Author(s): 小川晋, 他
  • Publisher: シュプリンガー・ジャパン
• [Book] 糖尿病慢性合併症(大血管症);内分泌・糖尿病内科学 (2011)
  • Author(s): 小川晋, 他
  • Publisher: 森昌朋編集;シュプリンガー・ジャパン