Regulatory roles of 25(OH) vitamin D on lipid raft

• Project/Area Number: 22659166
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Osaka University
• Principal Investigator: MATSUI Isao 大阪大学, 大学院・医学系研究科, 助教 (60456986)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,130,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: vitamin D / 25(OH) vitamin D / lipid raft / 腎保護 / 血管保護 / レニン / ビタミンD

Research Abstract

In this research, we showed that 25-hydroxyvitamin D[ 25(OH) D] itself has biological effects. The effects of 25(OH) D did not require its activation to 1, 25-dihydroxyvitamin D[ 1, 25(OH)_2D]. Our results suggested that 25(OH) D directly activates vitamin D receptor(VDR). Moreover, 25(OH) D modulated the functions of lipid raft.

Research Products

• [Journal Article] Combined Use of Vitamin D Status and FGF23 for Risk Stratification of Renal Outcome (2012)
  • Author(s): Nakano C, Hamano, T, Fujii N, Matsui I, Tomida K, Mikami S, Inoue K, Obi Y, Okada N, Tsubakihara Y, Isaka Y, Rakugi H
  • Journal Title: Clin J Am Soc Nephrol Volume: Vol.7 Pages: 810-819
  • Peer Reviewed
• [Presentation] Maxacalcitolはレニン抑制非依存的にUUOモデルラットの腎尿細管間質病変を改善する (2011)
  • Author(s): 井上和則、松井功
  • Organizer: The 5th Kidney Frontier
  • Place of Presentation: 東京
  • Year and Date: 2011-12-17
• [Presentation] Maxacalcitolはレニン抑制非依存的にUUOモデルラットの腎尿細管間質病変を改善する (2011)
  • Author(s): 井上和則、松井功
  • Organizer: The 5th Kidney Frontier
  • Place of Presentation: 日本、東京
  • Year and Date: 2011-12-17
• [Presentation] Maxacalcitol ameliorates tubulointer stitial fibrosis in the obstructed kidney (2011)
  • Author(s): Kazunori Inoue, Isao Matsui
  • Organizer: The 44th Meeting of the American society of Nephrology
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2011-11-11
• [Presentation] Combinational Usage of Vitamin D Status and the Earliest Marker Fibroblast Growth Factor 23 Improves Risk Stratification for Renal Outcome (2011)
  • Author(s): hikako Nakano, Takayuki Hamano, Naohiko Fujii, Isao Matsui, Kodo Tomida, Kazunori Inoue, Akihiro Shimomura, Yoshitsugu Obi, Hiromi Rakugi, Yoshitaka Isaka
  • Organizer: The 44th Meeting of the American society of Nephrology
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2011-11-11
• [Presentation] Maxacalcitol ameliorates tubulointerstitial fibrosis in the obstructed kidney (2011)
  • Author(s): Kazunori Inoue, Isao Matsui
  • Organizer: The 44th Meeting of the American society of Nephrology
  • Place of Presentation: アメリカ、フィラデルフィア
  • Year and Date: 2011-11-11
• [Presentation] Maxacalcitolはレニン抑制非依存的にUUOモデルラットの腎尿細管間質病変を改善する (2011)
  • Author(s): 井上和則、松井功
  • Organizer: Bone Research Joint Meeting
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-08
• [Presentation] Maxacalcitolは変速尿管結紮モデルラットの腎尿細管間質病変を改善する (2011)
  • Author(s): 井上和則
  • Organizer: Bone Research Joint Meeting
  • Place of Presentation: 日本、大阪
  • Year and Date: 2011-11-08
• [Presentation] Maxacalcitolはレニン抑制非依存的にUUOモデルラットの腎尿細管間質病変を改善する (2011)
  • Author(s): 井上和則、松井功
  • Organizer: 第30回腎と骨代謝研究会
  • Place of Presentation: 日本、東京
  • Year and Date: 2011-10-08
• [Presentation] A Comprehensive Approach for Predicting Renal Outcome by Laboratory Factors in CKD-MBD (2011)
  • Author(s): Chikako Nakano, Takayuki Hamano, Naohiko Fujii, Isao Matsui, Kodo Tomida, Yoshitsugu Obi, Hiromi Rakugi, Yoshitaka Isaka
  • Organizer: XLVIII European Reanl Association. European Dialysis and Transplant Association Congress
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2011-06-26
• [Presentation] Maxacalcitol ameliorates kidney injury in Dahl salt-sensitive rats in a renin-independent manner. (2010)
  • Author(s): 井上和則、松井功
  • Organizer: The 43th Annual Meeting of the American society of Nephrology
  • Place of Presentation: Denver, USA
  • Year and Date: 2010-11-20
• [Presentation] Maxacalcitolはレニン抑制非依存的にDahl食塩感受性ラットの腎障害を改善する (2010)
  • Author(s): 井上和則、松井功
  • Organizer: 第29回腎と骨代謝研究会
  • Place of Presentation: 東京、日本
  • Year and Date: 2010-10-02
• [Presentation] オキサロールの腎保護作用 (2010)
  • Author(s): 松井功
  • Organizer: オキサロール 10周年講演会
  • Place of Presentation: 東京、日本
  • Year and Date: 2010-09-07
• [Presentation] Maxacalcitolはレニン非依存的にDahl食塩感受性ラットの腎障害を改善する (2010)
  • Author(s): 井上和則、松井功
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸、日本
  • Year and Date: 2010-06-17
• [Presentation] Maxacalcitol ameliorates kidney injury in Dahl salt-sensitive rats in a renin-independent manner.
  • Author(s): 松井功
  • Organizer: XLVII ERA-EDTA congress
  • Place of Presentation: 20100627(Munich, Germany)
• [Book] ビタミンDの腎保護作用 (2010)
  • Author(s): 松井功
  • Publisher: 医学のあゆみ
• [Book] 医学のあゆみ「ビタミンDの腎保護作用」 (2010)
  • Author(s): 松井功(共著)
  • Publisher: 医歯薬出版