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Elucidation of the role of Pin1 on the adipose differentiation

Research Project

Project/Area Number 22659175
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionHiroshima University

Principal Investigator

ASANO Tomoichiro  広島大学, 大学院・医歯薬学総合研究科, 教授 (70242063)

Co-Investigator(Kenkyū-buntansha) NAKATSU Yusuke  広島大学, 大学院・医歯薬学総合研究科, 助教 (20452584)
Co-Investigator(Renkei-kenkyūsha) SAKODA Hideyuki  東京大学, 大学病院, 助教 (50376464)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsメタボリックシンドローム / プロリン異性化酵素 / 脂肪細胞 / インスリン作用
Research Abstract

We reported that Pin1 binds to Crtc2 and suppresses CRE transcriptional and gluconeogenic activity in the liver. In addition, Pin1 associates with IRS-1, a major insulin receptor substrate, and enhances insulin-induced metabolic actions. The associations of Pin1 with IRS-1 and Crtc2 ultimately contribute to the incorporation of excess nutrients into tissues, based on a data series obtained using in vitro and in vivo over-expressions of Pin1, gene silencing, a specific inhibitor and Pin1 knock-out mice. In addition, it was shown that Pin1 is also indispensable for differentiation from pre-adipocytes into mature adipocytes.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (42 results)

All 2012 2011 Other

All Journal Article (25 results) (of which Peer Reviewed: 20 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Prolyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells2012

    • Author(s)
      Uchida., T., Furumai, K., Fukuda, T., Akiyama, H., Takezawa, M., Asano, T., Fujimori, F., and Uchida, C.
    • Volume
      in press
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans2012

    • Author(s)
      Hasegawa, Y., Saito, T., Ogihara, T., Ishigaki, Y., Yamada, T., Imai, J., Uno, K., Gao, J., Kaneko, K., Shimosawa, T., Asano, T., Fujita, T., Oka, Y., and Katagiri, Y.
    • Volume
      125(9)
    • Pages
      1122-33
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Valsartan, independently of AT1 receptor or PPAR・2012

    • Author(s)
      Iwasita, M., Sakoda, H., Kushiyama, A., Fujishiro, M., Ohno, H., Nakatsu, Y., Fukushima, T., Kumamoto, S., Tsuchiya, Y., Kikuchi, T., Kurihara, H., Akazawa, H., Komuro, I., Kamata, H., Nishimura, F. and Asano, T.
    • Journal Title

      suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes Am. J. Physiol. Cell Physiol.

      Volume: 302 Pages: 286-96

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development2012

    • Author(s)
      Kushiyama, A., Okubo, H., Zhang, J., Sakoda, H., Kikuchi, T., Fujishiro, M., Sato, H., Kushiyama, S., Iwashita, M., Nishimura, F., Fukushima, T., Nakatsu, Y., Kamata, H., Kurihara, H., Kikuchi, M., Kawazu, S., and Asano, T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Pages: 291-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8 Obesity Res Clin Pract2012

    • Author(s)
      Kikuchi, T., Zhang, J., Sakoda, H., Koketsu, Y., Fujishiro, M., Kushiyama, A., Nakatsu, Y., Kamata, H., Inoki, K., Takahashi, S., Kurihara, H., Katagiri, H., Oka, Y., and Asano, T.
    • Volume
      in press
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation2012

    • Author(s)
      Nakarai, H., Yamashita, A., Nagayasu, S., Iwashita, M., Kumamoto, S., Ohyama, H., Hata, M., Soga, Y., Kushiyama, A., Asano, T., Abiko, Y., and Nishimura, F.
    • Journal Title

      Innate Immun

      Volume: 18 Pages: 164-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] SGLT2阻害薬2012

    • Author(s)
      大野晴也、浅野知一郎
    • Journal Title

      月刊糖尿病

      Volume: 12 Pages: 108-113

    • Related Report
      2011 Final Research Report
  • [Journal Article] 骨格筋におけるインスリン抵抗性2012

    • Author(s)
      大野晴也、浅野知一郎
    • Journal Title

      骨格筋におけるインスリン抵抗性

      Pages: 176-179

    • Related Report
      2011 Final Research Report
  • [Journal Article] SGLT 2 阻害薬 カレントテラピー2012

    • Author(s)
      大谷裕一郎、浅野知一郎
    • Journal Title

      治療薬

      Volume: 7月号 Pages: 24-28

    • Related Report
      2011 Final Research Report
  • [Journal Article] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrates (IRSs) forming a negative feedback loop in insulin/insulin-like growth factor (IGF) signaling2012

    • Author(s)
      Yoshihara, H., Fukushima, T., Asano, T.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells2012

    • Author(s)
      Uchida., T., Furumai, K., Asano, T.
    • Journal Title

      PLoS One

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages2012

    • Author(s)
      Kumamoto, S., kushiyama, A., Asano, T.
    • Journal Title

      Obesity Res Clin Pract

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptidyl-prolyl Cis/ Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis2011

    • Author(s)
      Nakatsu, Y., Sakoda, H., Kushiyama, A., Zhang, J., Ono, H., Fujishiro, M., Kikuchi, T., Fukushima, T., Yoneda, M., Ohno, H., Horike, N., Kanna, M., Tsuchiya, Y., Kamata, H., Nishimura, F., Isobe, T., Ogihara, T., Katagiri, H., Oka, Y., Takahashi, S., Kurihara, H., Uchida, T., and Asano, T.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 20812-22

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011

    • Author(s)
      Ohno, H., Nakatsu, Y., sakoda, H., Kushiyama, A., Ono, H., Fujishiro, M., Otani, Y., Okubo, H., Yoneda, M., Fukushima, T., Tsuchiya, Y., Kamata, H., Nishimura, F., Kurihara, H., Katagiri, H., Oka, Y., and Asano, T.
    • Journal Title

      Am. J. Physiol. Cell Physiol

      Volume: 300 Pages: 47-54

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells2011

    • Author(s)
      Fukushima, T., Okajima, H., Yamanaka, D., Ariga, M., Nagata, S., Ito, A., Yoshida, M., Asano, T., Chida, K., Hakuno, F., and Takahashi, S.
    • Journal Title

      Mol. Cell. Endocrinol

      Volume: 344 Pages: 81-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/ insulin-like growth factor-I receptor tyrosine kinases Biochem2011

    • Author(s)
      Fukushima, T., Arai, T., Ariga-Nedachi, M., Okajima, H., Ooi, Y., Iijima, Y., Sone, M., Cho, Y., Ando, Y., Kasahara, K., Ozon, A., Yoshihara, H., Chida, K., Okada, S., Kopchick, JJ., Asano, T., Hakuno, F., and Takahashi SI.
    • Journal Title

      Biophys. Res. Commun

      Volume: 404 Pages: 767-73

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calpain 6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1 J.2011

    • Author(s)
      Tonami, K., kurihara, Y., Arima, S., Nishiyama, K., Uchijima, Y., Asano, T., Sorimachi, H., and Kurihara, H.
    • Journal Title

      Cell Sci

      Volume: 124 Pages: 1214-23

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] mTORシグナルと糖脂質代謝異常2011

    • Author(s)
      迫田秀之、浅野知一郎
    • Journal Title

      実験医学

      Volume: 29(6) Pages: 895-899

    • Related Report
      2011 Final Research Report
  • [Journal Article] 糖輸送体2011

    • Author(s)
      大久保博史, 大野晴也, 浅野知一郎
    • Journal Title

      G. I. Research

      Volume: 19(5) Pages: 412-417

    • Related Report
      2011 Final Research Report
  • [Journal Article] HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells2011

    • Author(s)
      Fukushima, T., Okajima, H., Asano, T.
    • Journal Title

      Mol.Cell.Endocrinol.

      Volume: 344 Pages: 81-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases2011

    • Author(s)
      Fukushima, T., Arai, T., Asano, T.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 404 Pages: 767-73

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis2011

    • Author(s)
      Nakatsu, Y., Sakoda, H., Asano T., et al.
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Pages: 20812-20822

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011

    • Author(s)
      Ohno, H., Nakatsu, Y., Asano T., et al.
    • Journal Title

      Am.J.Physiol.Cell Physiol.

      Volume: 300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells2011

    • Author(s)
      Fukushima, T., Okajima, H., Asano T., et al.
    • Journal Title

      Mol.Cell.Endocrinol.

      Volume: 344 Pages: 81-89

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calpain 6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H12011

    • Author(s)
      Tonami, K., kurihara, Y., Asano T., et al.
    • Journal Title

      J.Cell Sci.

      Volume: 124 Pages: 1214-1223

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] プロリン異性化酵素Par14のインスリンシグナルと糖・脂質代謝における役割2011

    • Author(s)
      張君、郭瑩、浅野知一郎
    • Organizer
      第23回分子糖尿病シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Roles of peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 in non-alcoholic steatohepatitis2011

    • Author(s)
      中津祐介、福嶋俊明、浅野知一郎
    • Organizer
      日本生化学会
    • Place of Presentation
      京都市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Presentation] Nedd4 potentiates insulin signals through ubiquitination of IRS-2 in hepatocytes2011

    • Author(s)
      福嶋俊明、浅野知一郎
    • Organizer
      日本生化学会
    • Place of Presentation
      京都市
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)の発症におけるプロリン異性化酵素Pin1の役割2011

    • Author(s)
      迫田秀之、中津祐介、浅野知一郎
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Presentation] レジスチン関連蛋白β(RELMβ)の非アルコール性脂肪性肝炎(NASH)の発症における役割2011

    • Author(s)
      大久保博士、中津祐介、浅野知一郎
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Presentation] 転写共役因子CRTC3は高脂肪食によって発現誘導され、脂肪細胞分化と肝糖新生を促進する2011

    • Author(s)
      浅野知一郎、中津祐介、迫田秀之
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
  • [Presentation] LST8肝過剰発現マウスの糖脂質代謝に与える影響の解析2011

    • Author(s)
      菊池貴子、迫田秀之、浅野知一郎
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
  • [Presentation] プロリン異性化酵素Pin1類似蛋白Par14/ 17の生理的役割解明2011

    • Author(s)
      大野晴也、迫田秀之、浅野知一郎
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-19
    • Related Report
      2011 Final Research Report
  • [Presentation] キサンチンオキシダーゼ経路のマクロファージ泡沫化と動脈硬化への関与2011

    • Author(s)
      櫛山暁史、迫田秀之、浅野知一郎
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Trk(Trk-fused gene)はPTENに結合し、細胞内PIP3量を増加させることで、インスリン作用を促進させる2011

    • Author(s)
      大谷裕一郎、中津祐介、浅野知一郎
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)の発2011

    • Author(s)
      迫田秀之、中津祐介、浅野知一郎
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-19
    • Related Report
      2011 Final Research Report
  • [Presentation] ジスチン関連蛋白β(RELMβ)の非アルコール性脂肪性肝炎(NASH)の発症における役割2011

    • Author(s)
      大久保博士、中津祐介、浅野知一郎
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-19
    • Related Report
      2011 Final Research Report
  • [Presentation] モサプリドクエン酸塩の3T3-L1脂肪細胞におけるインスリン抵抗性改善作用の解明2011

    • Author(s)
      藤城緑、迫田秀之、浅野知一郎
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
  • [Presentation] プロリン異性化酵素Pin1類似蛋白Par14/17の生理的役割解明2011

    • Author(s)
      大野晴也、迫田秀之、浅野知一郎
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Presentation] Ubiquitination of insulin receptor substrate by Nedd4 potentiates insul in/IGF signals2011

    • Author(s)
      福嶋俊明、浅野知一郎
    • Organizer
      日本生化学会中国四国支部会
    • Place of Presentation
      広島市
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ubiquitination of insulin receptor substrate by Nedd4 potentiates insulin/IGF signals2011

    • Author(s)
      福嶋俊明、浅野知一郎
    • Organizer
      日本生化学会中国四国支部会
    • Place of Presentation
      広島市
    • Year and Date
      2011-05-14
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/ikagaku/

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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