Molecular basis of constitutive expression of PTHrP protein-Nuclear receptor, Hedgehog and ERBB2

• Project/Area Number: 22659179
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: Teikyo University
• Principal Investigator: OKAZAKI Tomoki 帝京大学, 医学部, 教授 (60203973)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 内分泌学 / PTHrP / 核内受容体 / 乳癌 / 前立腺癌 / PTH関連ペプチド(PTHrP) / ERBB2

Research Abstract

There is a common, at least in part, mechanism whereby PTHrP gene is negatively regulated by various steroid hormones. We analyzed molecular players involved in the crosstalk among nuclear receptors, hedgehog signal and ERBB2 oncogene expression when PTHrP gene is expressed.

Research Products

• [Journal Article] Negative regulation of parathyroid hormone-related protein expression by steroid hormones (2011)
  • Author(s): Kajitani T, Tamamori-Adachi M, Okinaga H, Chikamori M, Iizuka M, Okazaki T.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 407 Pages: 472-478
  • Peer Reviewed
• [Journal Article] Negative regulation of parathyroid hormone-related protein expression by steroid hormones (2011)
  • Author(s): Kajitani, T, Tamamori-Adachi, M, Okinaga, H, Chikamori, M, Iizuka, M, Okazaki, T
  • Journal Title: Biochem Biophys Res Commun Volume: 407 Issue: 3 Pages: 472-8
  • DOI: 10.1016/j.bbrc.2011.03.037
  • Peer Reviewed
• [Journal Article] Genes up-or down-regulated by high calcium medium in parathyroid tissue explants obtained from patients with primary hyperparathyroidism (2010)
  • Author(s): Nakajima K., T. Okazaki, T. Okamoto, H. Kimura, K. Takano, and K. Sato.
  • Journal Title: Endocrine J. Volume: 57 Pages: 153-159
  • Peer Reviewed
• [Journal Article] Negative regulation of parathyroid hormone-related hormone protein expression by steroid hormones
  • Author(s): Kajitani, T, Adachi-Tamamori M, Okazaki T.
  • Journal Title: Biochem.Biophys.Res.Comm. Volume: (In press)
  • Peer Reviewed
• [Presentation] Proteasome Inhibitor, but Not Cycloheximide, Commonly Alleviates Suppression of PTHrP Expression Mediated by Several Steroid Hormones in Breast, Cancer Cells (2011)
  • Author(s): T Kajitani, M Iizuka, M Tamamori-Adachi, T Okazaki
  • Organizer: American Endocrine Society Meeting Endo2011
  • Place of Presentation: ボストン(コンベンションセンター)
  • Year and Date: 2011-06-06
• [Presentation] P3-17 Proteasome Inhibitor, but Not Cycloheximide, Commonly Alleviates Suppression of PTHrP Expression Mediated by Several Steroid Hormones in Breast Cancer Cells (2011)
  • Author(s): T Kajitani, M Iizuka, M Tamamori-Adachi, T Okazaki
  • Organizer: American Endocrine Society Meeting Endo2011
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 2011-06-06
• [Presentation] 核内受容体(NR)に対するSiRNAを用いた培養乳癌細胞におけるPTHrP遺伝子発現抑制機構の解明 (2010)
  • Author(s): 梶谷宇、安達(玉盛)三美、飯塚眞由、岡崎具樹
  • Organizer: 第32回日本分子生物学会年会/第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09